Results 71 to 80 of about 9,722 (255)

Increased PARylation impacts the DNA methylation process in type 2 diabetes mellitus [PDF]

, 2021
Epigenetic modifications, such as DNA methylation, can influence the genetic susceptibility to type 2 diabetes mellitus (T2DM) and the progression of the disease.
L. Bertoccini, M. G. Cavallo, Cavallo, Maria Gisella, Zardo, Giuseppe, Tagliatesta, Stefano, M. G. Bacalini, Barchetta, Ilaria, G. De Matteis, Scalea, Stefania, S. Scalea, Bertoccini, Laura, A. Reale, Reale, Anna, G. Zardo, De Matteis, Giovanna, S. Tagliatesta, Bacalini, Maria Giulia, M. Zampieri, Zampieri, Michele, Cimini, Flavia Agata, I. Barchetta, F. A. Cimini   +21 more
core   +1 more source

The Oxidative Damage and Inflammation Mechanisms in GERD-Induced Barrett’s Esophagus

Frontiers in Cell and Developmental Biology, 2022
Barrett’s esophagus is a major complication of gastro-esophageal reflux disease and an important precursor lesion for the development of Barrett’s metaplasia and esophageal adenocarcinoma.
Deqiang Han, Deqiang Han, Chao Zhang
doaj   +1 more source

Proteomic Investigation of Phosphorylation Sites in Poly(ADP-ribose) Polymerase-1 and Poly(ADP-ribose) Glycohydrolase [PDF]

Journal of Proteome Research, 2008
Phosphorylation is a very common post-translational modification event known to modulate a wide range of biological responses. Beyond the regulation of protein activity, the interrelation of phosphorylation with other post-translational mechanisms is responsible for the control of diverse signaling pathways.
Gagné, Jean-Philippe, Moreel, Xavier, Gagné, Pierre, Labelle, Yves, Droit, Arnaud, Chevalier-Paré, Mélissa, Bourassa, Sylvie, Mcdonald, Darin, Hendzel, Michael, Prigent, Claude, Poirier, Guy   +10 more
openaire   +3 more sources

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

Higher plants possess two structurally different poly(ADP-ribose) polymerases

, 1998
One of the immediate reactions of the mammalian cell to many environmental stresses is a massive synthesis of poly(ADP-ribose), catalyzed by poly(ADP-ribose) polymerase (PARP).
Marc Van Montagu, Sergei Kushnir, Inzé, Dirk, Van Montagu, Marc, Mayuree Fuangthong, Yimin Chen, O'Farrell, Minnie K, Fuangthong, Mayuree, Elena Babiychuk, Storojenko, Serguei, Minnie K. O’Farrell, Chen, Yimin, Cottril, Phillippa B, Phillippa B. Cottrill, Sergei Storozhenko, Kushnir, Sergei, Babiychuk, Elena, Dirk Inzé   +17 more
core   +1 more source

Pemt Inhibition‐Mediated Vdac1 Oligomerization Regulates Mitochondrial Dysfunction, Apoptosis, and Inflammation in High‐Fat Diet‐Derived Liver Injury

Advanced Science, EarlyView.
ABSTRACT High‐fat diet (HFD)‐induced hepatic injury represents a pathology observed across vertebrates, yet the underlying mechanisms remain incompletely understood. Herein, the present study identifies phosphatidylethanolamine methyltransferase (Pemt), a key enzyme in phosphatidylcholine synthesis, as a critical regulator of mitochondrial homeostasis ...
Xianyong Bu, Xiufei Cao, Xin Yao, Baolin Li, Wencong Lai, Zengqi Zhao, Tingting Hao, Zhiwei Chen, Jianlong Du, Yueru Li, Kangsen Mai, Qinghui Ai   +11 more
wiley   +1 more source

Synthesis of Bispecific Antibody Conjugates Using Functionalized Poly-ADP-ribose Polymers

, 2023
Poly-ADP-ribose (PAR) is a natural type of polymer derived from enzymatic reactions catalyzed by cellular poly(ADP-ribose) polymerases (PARPs). Given its notable solubility and biocompatibility, the PAR polymer may function as effective carriers for ...
Yong Zhang (5893), Jingwen Chen (489529), Xiao-Nan Zhang (1797094), Qinqin Cheng (5988329), Jiawei Li (559407), Yiling Wang (620129)   +5 more
core   +1 more source

Regulation of Rad52-dependent replication fork recovery through serine ADP-ribosylation of PolD3

Nature Communications, 2023
Although Poly(ADP-ribose)-polymerases (PARPs) are key regulators of genome stability, how site-specific ADP-ribosylation regulates DNA repair is unclear.
Frederick Richards, Marta J. Llorca-Cardenosa, Jamie Langton, Sara C. Buch-Larsen, Noor F. Shamkhi, Abhishek Bharadwaj Sharma, Michael L. Nielsen, Nicholas D. Lakin   +7 more
doaj   +1 more source

TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain

Advanced Science, EarlyView.
TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando, Emanuele Buratti, Francesca Paron   +2 more
wiley   +1 more source

NAD+ Metabolism Licenses Zygotic Genome Activation via PARP7‐Mediated ADP‐Ribosylation of UHRF1 in Mouse Early Embryos

Advanced Science, EarlyView.
This study uncovers a metabolic‐epigenetic axis licensing zygotic genome activation (ZGA) in mouse embryos. A developmental decline in NAD+ levels activates PARP7, which mono‐ADP‐ribosylates and stabilizes UHRF1. This modification promotes the establishment of permissive histone acetylation marks, thereby facilitating timely ZGA.
Guangyi Cao, Ziqi Zhang, Anqi Chen, Yanbo Liu, Yuling Lin, Lina Yu, Ruixin Shi, Aolei Guo, Yan Mao, Ganggui Lou, Chaojun Li, Luhong Wen, Guijun Yan, Haixiang Sun   +13 more
wiley   +1 more source