Induction of Stress Granule Assembly is Essential for the Orchestration of DNA Damage Response [PDF]
, 2008 DNA damage provokes several responses including DNA repair, cell cycle regulation and apoptosis that collectively represent the DNA damage response (DDR).
Nicole S. Verkaik, Stephan Persengiev
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Requirement of the FATC domain of protein kinase Tel1 for localization to DNA ends and target protein recognition [PDF]
, 2015 Two large phosphatidylinositol 3-kinase-related protein kinases (PIKKs), ATM and ATR, play a central role in the DNA damage response pathway. PIKKs contain a highly conserved extreme C-terminus called the FRAP-ATM-TRRAP-C-terminal (FATC) domain.
Ghosh, A. +5 more
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Nature Communications, 2017 The DNA damage response (DDR) involves site-specific small non-coding RNAs. Here the authors show that telomere dysfunction induces transcription of telomeric DNA damage response RNAs that are necessary for DDR activation, which can be specifically muted
Francesca Rossiello +7 more
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Characterisation of the p53-Mediated Cellular Responses Evoked in Primary Mouse Cells Following Exposure to Ultraviolet Radiation [PDF]
, 2013 Exposure to ultraviolet (UV) light can cause significant damage to mammalian cells and, although the spectrum of damage produced varies with the wavelength of UV, all parts of the UV spectrum are recognised as being detrimental to human health ...
Allinson, Sarah +2 more
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O-GlcNAcylation of YTHDF2 antagonizes ERK-dependent phosphorylation and inhibits lung carcinoma
Fundamental ResearchThe intracellular O-linked N-acetylglucosamine (O-GlcNAc) glycosylation mediates many signal transduction events and regulates tumorigenesis. Previously the RNA N6-methyladenosine (m6A) reader, YTH (YT521-B homology) domain 2 (YTHDF2), has been shown to ...
Jie Li +7 more
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Analysis of DNA-Damage Response to ionizing radiation in serum-shock synchronized human fibroblasts. [PDF]
, 2017 Many aspects of cellular physiology, including cellular response to genotoxic stress, are related to the circadian rhythmicity induced by the molecular clock.
Barbieri, Vito +4 more
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Sumoylation and the DNA Damage Response
Biomolecules, 2012 The cellular response to DNA damage involves multiple pathways that work together to promote survival in the face of increased genotoxic lesions. Proteins in these pathways are often posttranslationally modified, either by small groups such as phosphate,
Xiaolan Zhao +2 more
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Curcumin-Mediated HDAC Inhibition Suppresses the DNA Damage Response and Contributes to Increased DNA Damage Sensitivity. [PDF]
PLoS ONE, 2015 Chemo- and radiotherapy cause multiple forms of DNA damage and lead to the death of cancer cells. Inhibitors of the DNA damage response are candidate drugs for use in combination therapies to increase the efficacy of such treatments.
Shu-Huei Wang +6 more
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Roles of DNA damage in renal tubular epithelial cells injury
Frontiers in Physiology, 2023 The prevalence of renal diseases including acute kidney injury (AKI) and chronic kidney disease (CKD) is increasing worldwide. However, the pathogenesis of most renal diseases is still unclear and effective treatments are still lacking.
Peipei Wang +14 more
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Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase [PDF]
, 2014 Upon DNA damage, cell cycle progression is temporally blocked to avoid propagation of mutations. While transformed cells largely maintain the competence to recover from a cell cycle arrest, untransformed cells past the G1/S transition lose mitotic ...
Cascales, H.S. +4 more
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