Dna damage response - Open Access .click

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Biomolecules, 2021
DNA in our cells is constantly modified by internal and external factors [...]
Valentyn Oksenych, Denis E. Kainov
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Medulloblastoma and the DNA Damage Response

Frontiers in Oncology, 2022
Medulloblastoma (MB) is the most common malignant brain tumor in children with standard of care consisting of surgery, radiation, and chemotherapy. Recent molecular profiling led to the identification of four molecularly distinct MB subgroups – Wingless (
Leon F. McSwain +9 more
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Lysine Crotonylation: An Emerging Player in DNA Damage Response

Biomolecules, 2022
The DNA damage response (DDR) system plays an important role in maintaining genome stability and preventing related diseases. The DDR network comprises many proteins and posttranslational modifications (PTMs) to proteins, which work in a coordinated ...
Yuqin Zhao +8 more
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HspBP1 is a dual function regulatory protein that controls both DNA repair and apoptosis in breast cancer cells

Cell Death and Disease, 2022
The Hsp70-binding protein 1 (HspBP1) belongs to a family of co-chaperones that regulate Hsp70 activity and whose biological significance is not well understood.
Cha Kyung Youn +10 more
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ULK1 in autophagy: sugar it up

Autophagy Reports, 2022
Autophagy is a highly conserved cellular degradation and recycling process in mammalian cells, which is comprised of three main types: microautophagy, macroautophagy, and chaperone-mediated autophagy (CMA).
Sheng Yan, Jing Li
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PLK1-mediated phosphorylation of PPIL2 regulates HR via CtIP

Frontiers in Cell and Developmental Biology, 2022
Homologous recombination (HR) is an error-free DNA double-strand break (DSB) repair pathway, which safeguards genome integrity and cell viability. Human C-terminal binding protein (CtBP)—interacting protein (CtIP) is a central regulator of the pathway ...
Zhiyu Qiu +8 more
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DNA Damage Tolerance Pathways in Human Cells: A Potential Therapeutic Target

Frontiers in Oncology, 2022
DNA lesions arising from both exogenous and endogenous sources occur frequently in DNA. During DNA replication, the presence of unrepaired DNA damage in the template can arrest replication fork progression, leading to fork collapse, double-strand break ...
Ashlynn Ai Li Ler, Michael P. Carty, Michael P. Carty +2 more
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Amelioration of cadmium cytotoxicity to human cells by nutrient cation contents and the building of a biotic ligand model

Ecotoxicology and Environmental Safety, 2023
A variety of important major and trace elements may competitively inhibit cadmium (Cd) absorption in human cells and reduce Cd toxicity. However, the impact of essential elements on the cytotoxicity of metals can be difficult to quantify and anticipate ...
Yujie Tang +3 more
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DNA damage checkpoint and repair: From the budding yeast Saccharomyces cerevisiae to the pathogenic fungus Candida albicans

Computational and Structural Biotechnology Journal, 2021
Cells are constantly challenged by internal or external genotoxic assaults, which may induce a high frequency of DNA lesions, leading to genome instability.
Shuangyan Yao, Yuting Feng, Yan Zhang, Jinrong Feng +3 more
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Utilization of a Strongly Inducible DDI2 Promoter to Control Gene Expression in Saccharomyces cerevisiae

Frontiers in Microbiology, 2018
Regulating target gene expression is a common method in yeast research. In Saccharomyces cerevisiae, there are several widely used regulated expression systems, such as the GAL and Tet-off systems.
Aiyang Lin +8 more
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