Results 11 to 20 of about 752,369 (314)
The Mitochondrial Response to DNA Damage [PDF]
Frontiers in Cell and Developmental Biology, 2021 Mitochondria are double membrane organelles in eukaryotic cells that provide energy by generating adenosine triphosphate (ATP) through oxidative phosphorylation. They are crucial to many aspects of cellular metabolism.
Ziye Rong +7 more
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Sumoylation and the DNA Damage Response [PDF]
Biomolecules, 2012 The cellular response to DNA damage involves multiple pathways that work together to promote survival in the face of increased genotoxic lesions. Proteins in these pathways are often posttranslationally modified, either by small groups such as phosphate,
Xiaolan Zhao +2 more
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Cold Spring Harbor Perspectives in Biology, 2010 Structural changes to DNA severely affect its functions, such as replication and transcription, and play a major role in age-related diseases and cancer. A complicated and entangled network of DNA damage response (DDR) mechanisms, including multiple DNA repair pathways, damage tolerance processes, and cell-cycle checkpoints safeguard genomic integrity.
Giglia-Mari, G. +2 more
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Engineering a DNA damage response without DNA damage [PDF]
Genome Biology, 2008 Recent work has achieved the feat of activating the DNA damage checkpoint in the absence of DNA damage, revealing the importance of protein-chromatin associations for the activation, amplification and maintenance of the DNA damage response.
Yeung, ManTek, Durocher, Daniel
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Sphingolipids in the DNA damage response [PDF]
Advances in Biological Regulation, 2015 Recently, sphingolipid metabolizing enzymes have emerged as important targets of many chemotherapeutics and DNA damaging agents and therefore play significant roles in mediating the physiological response of the cell to DNA damage. In this review we will highlight points of connection between the DNA damage response (DDR) and sphingolipid metabolism ...
Brittany, Carroll +2 more
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Autophagy in DNA Damage Response [PDF]
International Journal of Molecular Sciences, 2015 DNA damage response (DDR) involves DNA repair, cell cycle regulation and apoptosis, but autophagy is also suggested to play a role in DDR. Autophagy can be activated in response to DNA-damaging agents, but the exact mechanism underlying this activation is not fully understood, although it is suggested that it involves the inhibition of mammalian target
Czarny, Piotr +4 more
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miRNA response to DNA damage [PDF]
Trends in Biochemical Sciences, 2011 Faithful transmission of genetic material in eukaryotic cells requires not only accurate DNA replication and chromosome distribution but also the ability to sense and repair spontaneous and induced DNA damage. To maintain genomic integrity, cells undergo a DNA damage response using a complex network of signaling pathways composed of coordinate sensors,
Guohui, Wan +4 more
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OCT4A and the DNA damage response [PDF]
Cell Cycle, 2015 OCT4A is best known as a “master” transcription factor involved in stem cell pluripotency and self renewal in concert with SOX2 and NANOG. Although there has been some indication of a dialog between OCT4 and elements of DNA repair,1 a recent article published in Cell Cycle by Huna and colleagues2 establishes OCT4A as a multifunctional protein with a ...
Murray, David, Mirzayans, Razmik
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PARPs and the DNA damage response [PDF]
Carcinogenesis, 2012 Adenosine diphosphate (ADP)-ribosylation is an important posttranslational modification catalyzed by a variety of enzymes, including poly (ADP ribose) polymerases (PARPs), which use nicotinamide adenine dinucleotide (NAD(+)) as a substrate to synthesize and transfer ADP-ribose units to acceptor proteins.
Fabricio G, Sousa +6 more
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Transcriptional responses to DNA damage [PDF]
DNA Repair, 2019 In response to the threat of DNA damage, cells exhibit a dramatic and multi-factorial response spanning from transcriptional changes to protein modifications, collectively known as the DNA damage response (DDR). Here, we review the literature surrounding the transcriptional response to DNA damage.
Erica, Silva, Trey, Ideker
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