Results 11 to 20 of about 1,213,538 (303)

DNA Damage Response [PDF]

Biomolecules, 2021
DNA in our cells is constantly modified by internal and external factors [...]
Valentyn Oksenych, Denis E. Kainov
doaj   +6 more sources

Radiation induced DNA damage responses [PDF]

Radiation Protection Dosimetry, 2006
The amazing feature of ionising radiation (IR) as a DNA damaging agent is the range of lesions it induces. Such lesions include base damage, single strand breaks (SSBs), double strand breaks (DSBs) of varying complexity and DNA cross links.
Jeggo, Penny, Löbrich, Markus
core   +4 more sources

Autophagy in DNA Damage Response [PDF]

International Journal of Molecular Sciences, 2015
DNA damage response (DDR) involves DNA repair, cell cycle regulation and apoptosis, but autophagy is also suggested to play a role in DDR. Autophagy can be activated in response to DNA-damaging agents, but the exact mechanism underlying this activation ...
Elzbieta Pawlowska, Janusz Blasiak, Jolanta Bialkowska-Warzecha, Kai Kaarniranta, Piotr Czarny   +4 more
core   +5 more sources

Interplay of space radiation and microgravity in DNA damage and DNA damage response [PDF]

npj Microgravity, 2017
In space, multiple unique environmental factors, particularly microgravity and space radiation, pose constant threat to the DNA integrity of living organisms.
María Moreno-Villanueva, Michael Wong, Tao Lu, Ye Zhang, Honglu Wu   +4 more
doaj   +3 more sources

DNA Damage Response Pathways in Dinoflagellates [PDF]

Microorganisms, 2019
Dinoflagellates are a general group of phytoplankton, ubiquitous in aquatic environments. Most dinoflagellates are non-obligate autotrophs, subjected to potential physical and chemical DNA-damaging agents, including UV irradiation, in the euphotic zone ...
Chongping Li, Joseph Tin Yum Wong
doaj   +4 more sources

Lysine Crotonylation: An Emerging Player in DNA Damage Response

Biomolecules, 2022
The DNA damage response (DDR) system plays an important role in maintaining genome stability and preventing related diseases. The DDR network comprises many proteins and posttranslational modifications (PTMs) to proteins, which work in a coordinated ...
Yuqin Zhao, Shuailin Hao, Wenchi Wu, Youhang Li, Kaiping Hou, Yu Liu, Wei Cui, Xingzhi Xu, Hailong Wang   +8 more
doaj   +1 more source

DNA Damage Response [PDF]

Cold Spring Harbor Perspectives in Biology, 2010
Structural changes to DNA severely affect its functions, such as replication and transcription, and play a major role in age-related diseases and cancer. A complicated and entangled network of DNA damage response (DDR) mechanisms, including multiple DNA repair pathways, damage tolerance processes, and cell-cycle checkpoints safeguard genomic integrity.
Giglia-Mari, G., Zotter, A., Vermeulen, W.   +2 more
openaire   +4 more sources

HspBP1 is a dual function regulatory protein that controls both DNA repair and apoptosis in breast cancer cells

Cell Death and Disease, 2022
The Hsp70-binding protein 1 (HspBP1) belongs to a family of co-chaperones that regulate Hsp70 activity and whose biological significance is not well understood.
Cha Kyung Youn, Jung-Hee Lee, Gurusamy Hariharasudhan, Hong Beum Kim, Jeeho Kim, Sumi Lee, Sung-Chul Lim, Sang-Pil Yoon, Sang-Gon Park, In-Youb Chang, Ho Jin You   +10 more
doaj   +1 more source

Engineering a DNA damage response without DNA damage [PDF]

Genome Biology, 2008
Recent work has achieved the feat of activating the DNA damage checkpoint in the absence of DNA damage, revealing the importance of protein-chromatin associations for the activation, amplification and maintenance of the DNA damage response.
Yeung, ManTek, Durocher, Daniel
openaire   +2 more sources

ULK1 in autophagy: sugar it up

Autophagy Reports, 2022
Autophagy is a highly conserved cellular degradation and recycling process in mammalian cells, which is comprised of three main types: microautophagy, macroautophagy, and chaperone-mediated autophagy (CMA).
Sheng Yan, Jing Li
doaj   +1 more source