Results 11 to 20 of about 7,503,880 (242)
Biomolecules, 2021 DNA in our cells is constantly modified by internal and external factors [...]
Valentyn Oksenych, Denis E. Kainov
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Medulloblastoma and the DNA Damage Response
Frontiers in Oncology, 2022 Medulloblastoma (MB) is the most common malignant brain tumor in children with standard of care consisting of surgery, radiation, and chemotherapy. Recent molecular profiling led to the identification of four molecularly distinct MB subgroups – Wingless (
Leon F. McSwain +9 more
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The Mitochondrial Response to DNA Damage [PDF]
Frontiers in Cell and Developmental Biology, 2021 Mitochondria are double membrane organelles in eukaryotic cells that provide energy by generating adenosine triphosphate (ATP) through oxidative phosphorylation. They are crucial to many aspects of cellular metabolism.
Ziye Rong +7 more
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Sumoylation and the DNA Damage Response [PDF]
Biomolecules, 2012 The cellular response to DNA damage involves multiple pathways that work together to promote survival in the face of increased genotoxic lesions. Proteins in these pathways are often posttranslationally modified, either by small groups such as phosphate,
Xiaolan Zhao +2 more
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Identifying a role for Ciz1 in the DNA damage response [PDF]
, 2011 In proliferating cells, cell cycle arrest and DNA repair are induced upon detection of DNA damage. The DNA damage response (DDR) to double strand DNA breaks is mediated by phosphatidylinositol 3-kinase-like protein kinases (PIKKs), which propagate DDR ...
Roper, Katherine
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DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts. [PDF]
, 2002 Alkylating agents, such as methyl methanesulfonate (MMS), damage DNA and activate the DNA damage checkpoint. Although many of the checkpoint proteins that transduce damage signals have been identified and characterized, the mechanism that senses the ...
Lindsay, Howard D. +3 more
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Lysine Crotonylation: An Emerging Player in DNA Damage Response
Biomolecules, 2022 The DNA damage response (DDR) system plays an important role in maintaining genome stability and preventing related diseases. The DDR network comprises many proteins and posttranslational modifications (PTMs) to proteins, which work in a coordinated ...
Yuqin Zhao +8 more
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Cold Spring Harbor Perspectives in Biology, 2010 Structural changes to DNA severely affect its functions, such as replication and transcription, and play a major role in age-related diseases and cancer. A complicated and entangled network of DNA damage response (DDR) mechanisms, including multiple DNA repair pathways, damage tolerance processes, and cell-cycle checkpoints safeguard genomic integrity.
Giglia-Mari, G. +2 more
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Cell Death and Disease, 2022 The Hsp70-binding protein 1 (HspBP1) belongs to a family of co-chaperones that regulate Hsp70 activity and whose biological significance is not well understood.
Cha Kyung Youn +10 more
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Engineering a DNA damage response without DNA damage [PDF]
Genome Biology, 2008 Recent work has achieved the feat of activating the DNA damage checkpoint in the absence of DNA damage, revealing the importance of protein-chromatin associations for the activation, amplification and maintenance of the DNA damage response.
Yeung, ManTek, Durocher, Daniel
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