Results 31 to 40 of about 7,503,880 (242)
Computational and Structural Biotechnology Journal, 2021 Cells are constantly challenged by internal or external genotoxic assaults, which may induce a high frequency of DNA lesions, leading to genome instability.
Shuangyan Yao +3 more
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DNA damage responses in ageing [PDF]
Open Biology, 2019 Ageing appears to be a nearly universal feature of life, ranging from unicellular microorganisms to humans. Longevity depends on the maintenance of cellular functionality, and an organism's ability to respond to stress has been linked to functional maintenance and longevity.
Paulo F. L. da Silva, Björn Schumacher
openaire +3 more sources
Frontiers in Microbiology, 2018 Regulating target gene expression is a common method in yeast research. In Saccharomyces cerevisiae, there are several widely used regulated expression systems, such as the GAL and Tet-off systems.
Aiyang Lin +8 more
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Cell Reports, 2014 The R2TP cochaperone complex plays a critical role in the assembly of multisubunit machines, including small nucleolar ribonucleoproteins (snoRNPs), RNA polymerase II, and the mTORC1 and SMG1 kinase complexes, but the molecular basis of substrate ...
Zuzana Hořejší +9 more
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A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation. [PDF]
, 2011 BACKGROUND: The mammalian DNA-damage response (DDR) has evolved to protect genome stability and maximize cell survival following DNA-damage. One of the key regulators of the DDR is p53, itself tightly regulated by MDM2. Following double-strand DNA breaks
Valentine, Jane M. +11 more
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DNA Damage and DNA Damage Response in Chronic Myeloid Leukemia [PDF]
International Journal of Molecular Sciences, 2020 DNA damage and alterations in the DNA damage response (DDR) are critical sources of genetic instability that might be involved in BCR-ABL1 kinase-mediated blastic transformation of chronic myeloid leukemia (CML). Here, increased DNA damage is detected by γH2AX foci analysis in peripheral blood mononuclear cells (PBMCs) of de novo untreated chronic ...
Henning D. Popp +10 more
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Autophagic Organelles in DNA Damage Response
Frontiers in Cell and Developmental Biology, 2021 Autophagy is an important subcellular event engaged in the maintenance of cellular homeostasis via the degradation of cargo proteins and malfunctioning organelles.
Jeongha Kim +7 more
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Deciphering the DNA Damage Response [PDF]
Cell, 2015 This year's Albert Lasker Basic Medical Research Award honors Evelyn Witkin and Stephen J. Elledge, two pioneers in elucidating the DNA damage response, whose contributions span more than 40 years.
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Autophagy in DNA Damage Response [PDF]
International Journal of Molecular Sciences, 2015 DNA damage response (DDR) involves DNA repair, cell cycle regulation and apoptosis, but autophagy is also suggested to play a role in DDR. Autophagy can be activated in response to DNA-damaging agents, but the exact mechanism underlying this activation is not fully understood, although it is suggested that it involves the inhibition of mammalian target
Czarny, Piotr +4 more
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The concerted roles of FANCM and Rad52 in the protection of common fragile sites
Nature Communications, 2018 Fanconi anemia core proteins have been linked to common fragile site stability. Here the authors shed light into the role of FANCM in common fragile site protection by suppressing double-strand break formation and mitotic recombination.
Hailong Wang +5 more
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