Results 31 to 40 of about 716,098 (263)
Exploring the links between cancer and placenta development [PDF]
Open Biology, 2018 The development of metastatic cancer is a multistage process, which often requires decades to complete. Impairments in DNA damage control and DNA repair in cancer cell precursors generate genetically heterogeneous cell populations.
Vincenzo Costanzo +3 more
doaj +1 more source
SUMO in the DNA damage response
Oncotarget, 2015 Post-translational modification by Small Ubiquitin-like Modifiers (SUMOs) is critical for all eukaryotic life [1]. SUMO, like ubiquitin, is conjugated to lysine residues in target proteins through an enzymatic cascade involving E1, E2 and E3 enzymes, and SUMOylation of proteins can be reversed through the action of SUMO-specific proteases.
Hendriks, I.A., Vertegaal, A.C.O.
openaire +3 more sources
The RNA Response to DNA Damage [PDF]
Journal of Molecular Biology, 2016 Multicellular organisms must ensure genome integrity to prevent accumulation of mutations, cell death, and cancer. The DNA damage response (DDR) is a complex network that senses, signals, and executes multiple programs including DNA repair, cell cycle arrest, senescence, and apoptosis.
Giono, Luciana E. +5 more
openaire +3 more sources
EMBO ReportsCyclosporin A (CsA) induces DNA double-strand breaks in LIG4 syndrome fibroblasts, specifically upon transit through S-phase. The basis underlying this has not been described.
Marisa Bedir +5 more
doaj +1 more source
Histone post-translational modification and the DNA damage response
Genes and Diseases, 2023 DNA is highly vulnerable to spontaneous and environmental timely damage in living cells. DNA damage may cause genetic instability and increase cancer risk if the damages are not repaired timely and efficiently.
Haoyun Song +6 more
doaj +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Cellular Responses to DNA Damage
Annual Review of Pharmacology and Toxicology, 2001 Cells are constantly under threat from the cytotoxic and mutagenic effects of DNA damaging agents. These agents can either be exogenous or formed within cells. Environmental DNA-damaging agents include UV light and ionizing radiation, as well as a variety of chemicals encountered in foodstuffs, or as air- and water-borne agents.
Norbury, C, Hickson, I
openaire +3 more sources
Ribonucleotide triggered DNA damage and RNA-DNA damage responses [PDF]
RNA Biology, 2014 Research indicates that the transient contamination of DNA with ribonucleotides exceeds all other known types of DNA damage combined. The consequences of ribose incorporation into DNA, and the identity of protein factors operating in this RNA-DNA realm to protect genomic integrity from RNA-triggered events are emerging. Left unrepaired, the presence of
Bret D, Wallace, R Scott, Williams
openaire +2 more sources
Nature Communications, 2017 ATR kinase activity is essential for slowing replication forks and preventing DNA replication in cells with DNA damage. Here the authors show that ATR inhibition leads to Cdc7 phosphorylation of GINS, leading to origin firing.
Tatiana Moiseeva +5 more
doaj +1 more source
Biology Open, 2018 Spermatozoa carry DNA damage that must be repaired by the oocyte machinery upon fertilization. Different strategies could be adopted by different vertebrates to face the paternal genotoxic damage.
Cristina Fernández-Díez +3 more
doaj +1 more source