Results 1 to 10 of about 7,534,152 (213)

Why Human Papillomaviruses Activate the DNA Damage Response (DDR) and How Cellular and Viral Replication Persists in the Presence of DDR Signaling [PDF]

Viruses, 2017
Human papillomaviruses (HPV) require the activation of the DNA damage response (DDR) in order to undergo a successful life cycle. This activation presents a challenge for the virus and the infected cell: how does viral and host replication proceed in the presence of a DDR that ordinarily arrests replication; and how do HPV16 infected cells retain the ...
Molly Bristol, Iain Morgan, Dipon Das
exaly   +4 more sources

The plant‐specific DDR factor SOG1 increases chromatin mobility in response to DNA damage [PDF]

The EMBO Reports, 2022
Homologous recombination (HR) is a conservative DNA repair pathway in which intact homologous sequences are used as a template for repair. How the homology search happens in the crowded space of the cell nucleus is, however, still poorly understood. Here, we measure chromosome and double-strand break (DSB) site mobility in Arabidopsis thaliana, using ...
Anis Meschichi, Lihua Zhao, Svenja Reeck, Charles White, Olivier Da Ines, Adrien Sicard, Frédéric Pontvianne, Stefanie Rosa   +7 more
openaire   +5 more sources

Epigenetic targeting of DNA damage response (DDR)-related mechanisms to overcome acquired cisplatin resistance of tumor cells

Biochimica Et Biophysica Acta - Molecular Cell Research
Mechanisms of the DNA damage response (DDR) are considered as useful targets to overcome tumor cell resistance. We investigated the impact of various classes of histone deacetylase inhibitors (HDACi) (i.e. broad-spectrum HDACi (vorinostat), class I HDACi (entinostat), preferential class IIb HDAC6i (ricolinostat) and dual HDAC class I/IIb inhibitors ...
Fabian Fischer
exaly   +3 more sources

Triple kill: DDR inhibitors, radiotherapy and immunotherapy leave cancer cells with no escape

Acta Biochimica et Biophysica Sinica, 2022
Radiotherapy (RT) has been widely used in the clinical treatment of cancers, but radiotherapy resistance (RR) leads to RT failure, tumor recurrence and metastasis.
Qiu Yuyue, Hu Xinru, Zeng Xiaoping, Wang Hongmei   +3 more
doaj   +1 more source

Differential DNA Damage Response of Peripheral Blood Lymphocyte Populations

Frontiers in Immunology, 2021
DNA damage occurs constantly in every cell triggered by endogenous processes of replication and metabolism, and external influences such as ionizing radiation and intercalating chemicals.
Kerstin Felgentreff, Catharina Schuetz, Ulrich Baumann, Christian Klemann, Dorothee Viemann, Simona Ursu, Eva-Maria Jacobsen, Klaus-Michael Debatin, Ansgar Schulz, Manfred Hoenig, Manfred Hoenig, Klaus Schwarz, Klaus Schwarz   +12 more
doaj   +1 more source

From yeast to humans: Understanding the biology of DNA Damage Response (DDR) kinases [PDF]

Genetics and Molecular Biology, 2020
The DNA Damage Response (DDR) is a complex network of biological processes that protect cells from accumulating aberrant DNA structures, thereby maintaining genomic stability and, as a consequence, preventing the development of cancer and other diseases.
José Renato Rosa Cussiol, Bárbara Luísa Soares, Francisco Meirelles Bastos de Oliveira   +2 more
openaire   +5 more sources

Wip1 downregulation conserves truncated DNA damage response (DDR) in mitosis [PDF]

Cell Cycle, 2013
Comment on: Macurek L, et al. Cell Cycle 2012; 12:251-62.
Vaz, B, Ramadan, K
openaire   +3 more sources

Not All DDRs Are Created Equal: Non-Canonical DNA Damage Responses [PDF]

Cell, 2015
It is commonly assumed that there is a single canonical DNA damage response (DDR) that protects cells from various types of double-strand breaks and that its activation occurs via recognition of DNA ends by the DDR machinery. Recent work suggests that both assumptions may be oversimplifications.
Burgess, Rebecca C., Misteli, Tom
openaire   +2 more sources

Determining the Potential of DNA Damage Response (DDR) Inhibitors in Cervical Cancer Therapy

Cancers, 2022
Cisplatin-based chemo-radiotherapy (CRT) is the standard treatment for advanced cervical cancer (CC) but the response rate is poor (46–72%) and cisplatin is nephrotoxic. Therefore, better treatment of CC is urgently needed. We have directly compared, for the first time, the cytotoxicity of four DDR inhibitors (rucaparib/PARPi, VE-821/ATRi, PF-477736 ...
Santu Saha, Stuart Rundle, Ioannis C. Kotsopoulos, Jacob Begbie, Rachel Howarth, Isabel Y. Pappworth, Asima Mukhopadhyay, Ali Kucukmetin, Kevin J. Marchbank, Nicola Curtin   +9 more
openaire   +4 more sources

Chromatin Ubiquitination Guides DNA Double Strand Break Signaling and Repair

Frontiers in Cell and Developmental Biology, 2022
Chromatin is the context for all DNA-based molecular processes taking place in the cell nucleus. The initial chromatin structure at the site of the DNA damage determines both, lesion generation and subsequent activation of the DNA damage response (DDR ...
Ksenia G. Kolobynina, Alexander Rapp, M. Cristina Cardoso   +2 more
doaj   +1 more source