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Methodological Landscape of DNA Damage Response Detection: From Conventional Assays to Future Innovations [PDF]

Current Issues in Molecular Biology
All living organisms possess a DNA damage response (DDR) that is important for genetic evolution. Cells have developed comprehensive mechanisms for addressing DNA damage, collectively called the DNA damage response and repair.
Yan Xi, Xinchen Yan, Jiahao Liu, Siqi Li, Xinyang Zhang, Yiwen Hou, Minjie Chu, Minfeng Yang   +7 more
doaj   +2 more sources

Targeting Mechanisms of the DNA Damage Response (DDR) and DNA Repair by Natural Compounds to Improve cAT-Triggered Tumor Cell Death. [PDF]

Molecules, 2022
Aengenvoort J, Sekeres M, Proksch P, Fritz G.   +3 more
europepmc   +2 more sources

The Interplay between the DNA Damage Response (DDR) Network and the Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway in Multiple Myeloma. [PDF]

Int J Mol Sci
Malamos P, Papanikolaou C, Gavriatopoulou M, Dimopoulos MA, Terpos E, Souliotis VL.   +5 more
europepmc   +2 more sources

Triple kill: DDR inhibitors, radiotherapy and immunotherapy leave cancer cells with no escape

Acta Biochimica et Biophysica Sinica, 2022
Radiotherapy (RT) has been widely used in the clinical treatment of cancers, but radiotherapy resistance (RR) leads to RT failure, tumor recurrence and metastasis.
Qiu Yuyue, Hu Xinru, Zeng Xiaoping, Wang Hongmei   +3 more
doaj   +1 more source

Differential DNA Damage Response of Peripheral Blood Lymphocyte Populations

Frontiers in Immunology, 2021
DNA damage occurs constantly in every cell triggered by endogenous processes of replication and metabolism, and external influences such as ionizing radiation and intercalating chemicals.
Kerstin Felgentreff, Catharina Schuetz, Ulrich Baumann, Christian Klemann, Dorothee Viemann, Simona Ursu, Eva-Maria Jacobsen, Klaus-Michael Debatin, Ansgar Schulz, Manfred Hoenig, Manfred Hoenig, Klaus Schwarz, Klaus Schwarz   +12 more
doaj   +1 more source

Chromatin Ubiquitination Guides DNA Double Strand Break Signaling and Repair

Frontiers in Cell and Developmental Biology, 2022
Chromatin is the context for all DNA-based molecular processes taking place in the cell nucleus. The initial chromatin structure at the site of the DNA damage determines both, lesion generation and subsequent activation of the DNA damage response (DDR ...
Ksenia G. Kolobynina, Alexander Rapp, M. Cristina Cardoso   +2 more
doaj   +1 more source

HIV Vpr Modulates the Host DNA Damage Response at Two Independent Steps to Damage DNA and Repress Double-Strand DNA Break Repair

mBio, 2020
The DNA damage response (DDR) is a signaling cascade that is vital to ensuring the fidelity of the host genome in the presence of genotoxic stress.
Donna Li, Andrew Lopez, Carina Sandoval, Randilea Nichols Doyle, Oliver I. Fregoso   +4 more
doaj   +1 more source

Targeting DNA damage response deficiency in the treatment of breast cancer [PDF]

Zhongguo aizheng zazhi, 2022
DNA damage response (DDR) deficiency has been one of the emerging targets in treating breast cancer in recent years. The DDR pathway is essential for the identification, signal transduction and repair of DNA damage.
Yizi JIN, Mingxi LIN, Jian ZHANG
doaj   +2 more sources

DNA Damage Response and Immune Defence: Links and Mechanisms

Frontiers in Genetics, 2016
DNA damage plays a causal role in numerous human pathologies including cancer, premature aging and chronic inflammatory conditions. In response to genotoxic insults, the DNA damage response (DDR) orchestrates DNA damage checkpoint activation and ...
Björn Schumacher, Rania Nakad
doaj   +1 more source

Activation of DNA Damage Response Signaling by Condensed Chromatin

Cell Reports, 2014
Summary: The DNA damage response (DDR) occurs in the context of chromatin, and architectural features of chromatin have been implicated in DNA damage signaling and repair. Whereas a role of chromatin decondensation in the DDR is well established, we show
Rebecca C. Burgess, Bharat Burman, Michael J. Kruhlak, Tom Misteli   +3 more
doaj   +1 more source