Results 11 to 20 of about 24,752 (187)

Why Human Papillomaviruses Activate the DNA Damage Response (DDR) and How Cellular and Viral Replication Persists in the Presence of DDR Signaling. [PDF]

Viruses, 2017
Bristol ML, Das D, Morgan IM.
europepmc   +2 more sources

Imaging the Response to DNA Damage in Heterochromatin Domains

Frontiers in Cell and Developmental Biology, 2022
The eukaryotic genome is assembled in a nucleoprotein complex called chromatin, whose organization markedly influences the repair of DNA lesions. For instance, compact chromatin states, broadly categorized as heterochromatin, present a challenging ...
Audrey Chansard, Enrico Pobega, Pierre Caron, Sophie E. Polo   +3 more
doaj   +1 more source

SIRT1 Involved in the Regulation of Alternative Splicing Affects the DNA Damage Response in Neural Stem Cells

Cellular Physiology and Biochemistry, 2018
Background/Aims: Alternative splicing and DNA damage exhibit cross-regulation, with not only DNA damage inducing changes in alternative splicing, but alternative splicing itself possibly modulating the DNA damage response (DDR).
Guangming Wang, Fangce Wang, Jie Ren, Yue Qiu, Wenjun Zhang, Shane Gao, Danjing Yang, Zhigang Wang, Aibin Liang, Zhengliang Gao, Jun Xu   +10 more
doaj   +1 more source

CCN2 Aggravates the Immediate Oxidative Stress–DNA Damage Response following Renal Ischemia–Reperfusion Injury

Antioxidants, 2021
AKI, due to the fact of altered oxygen supply after kidney transplantation, is characterized by renal ischemia–reperfusion injury (IRI). Recent data suggest that AKI to CKD progression may be driven by cellular senescence evolving from prolonged DNA ...
Floris A. Valentijn, Sebastiaan N. Knoppert, Georgios Pissas, Raúl R. Rodrigues-Diez, Laura Marquez-Exposito, Roel Broekhuizen, Michal Mokry, Lennart A. Kester, Lucas L. Falke, Roel Goldschmeding, Marta Ruiz-Ortega, Theodoros Eleftheriadis, Tri Q. Nguyen   +12 more
doaj   +1 more source

Regulation of the DNA Damage Response by Ubiquitin Conjugation

Frontiers in Genetics, 2015
In response to DNA damage, cells activate a highly conserved and complex kinase-based signaling network, commonly referred to as the DNA damage response (DDR), to safeguard genomic integrity.
Kerstin eBrinkmann, Kerstin eBrinkmann, Michael eSchell, Michael eSchell, Thorsten eHoppe, Thorsten eHoppe, Hamid eKashkar, Hamid eKashkar   +7 more
doaj   +1 more source

DNA damage response inhibition‐based combination therapies in cancer treatment: Recent advances and future directions

Aging and Cancer, 2022
DNA molecules are subject to various lesions that can be detrimental to the cells. DNA damage response (DDR) pathways encompass a variety of mechanisms that cells employ in response to DNA damage.
Tianen Chen, Suparat Tongpeng, Ziyi Lu, Win Topatana, Sarun Juengpanich, Shijie Li, Jiahao Hu, Jiasheng Cao, Cheeshin Lee, Yitong Tian, Mingyu Chen, Xiujun Cai   +11 more
doaj   +1 more source

DNA damage induced during mitosis undergoes DNA repair synthesis.

PLoS ONE, 2020
Understanding the mitotic DNA damage response (DDR) is critical to our comprehension of cancer, premature aging and developmental disorders which are marked by DNA repair deficiencies.
Veronica Gomez Godinez, Sami Kabbara, Adria Sherman, Tao Wu, Shirli Cohen, Xiangduo Kong, Jose Luis Maravillas-Montero, Zhixia Shi, Daryl Preece, Kyoko Yokomori, Michael W Berns   +10 more
doaj   +1 more source

The Adenovirus E4orf4 Protein Provides a Novel Mechanism for Inhibition of the DNA Damage Response. [PDF]

PLoS Pathogens, 2016
The DNA damage response (DDR) is a conglomerate of pathways designed to detect DNA damage and signal its presence to cell cycle checkpoints and to the repair machinery, allowing the cell to pause and mend the damage, or if the damage is too severe, to ...
Anna Brestovitsky, Keren Nebenzahl-Sharon, Peter Kechker, Rakefet Sharf, Tamar Kleinberger   +4 more
doaj   +1 more source

DNA single-strand break-induced DNA damage response causes heart failure

Nature Communications, 2017
DNA damage response (DDR) is activated in cardiomyocytes of the failing heart, but the type of DNA damage leading to DDR is unclear. Higoet al. show that in mice heart failure is caused in part by unrepaired DNA single-strand breaks in cardiomyocytes ...
Tomoaki Higo, Atsuhiko T. Naito, Tomokazu Sumida, Masato Shibamoto, Katsuki Okada, Seitaro Nomura, Akito Nakagawa, Toshihiro Yamaguchi, Taku Sakai, Akihito Hashimoto, Yuki Kuramoto, Masamichi Ito, Shungo Hikoso, Hiroshi Akazawa, Jong-Kook Lee, Ichiro Shiojima, Peter J. McKinnon, Yasushi Sakata, Issei Komuro   +18 more
doaj   +1 more source

DNA damage response and Autophagy: a meaningful partnership

Frontiers in Genetics, 2016
Autophagy and the DNA damage response (DDR) are biological processes essential for cellular and organismal homeostasis. Herein we summarize and discuss emerging evidence linking DDR to autophagy. We highlight published data suggesting that autophagy is
ARISTIDES G ELIOPOULOS, ARISTIDES G ELIOPOULOS, Sophia Havaki, Vassilis G Gorgoulis, Vassilis G Gorgoulis, Vassilis G Gorgoulis   +5 more
doaj   +1 more source