Results 11 to 20 of about 7,534,152 (213)
A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation [PDF]
BMC Cancer, 2011 Background The mammalian DNA-damage response (DDR) has evolved to protect genome stability and maximize cell survival following DNA-damage. One of the key regulators of the DDR is p53, itself tightly regulated by MDM2. Following double-strand DNA breaks (
Kumar Sonia +2 more
doaj +3 more sources
Nature Communications, 2017 The DNA damage response (DDR) involves site-specific small non-coding RNAs. Here the authors show that telomere dysfunction induces transcription of telomeric DNA damage response RNAs that are necessary for DDR activation, which can be specifically muted
Francesca Rossiello +7 more
doaj +3 more sources
DNA damage response (DDR) pathway engagement in cisplatin radiosensitization of non-small cell lung cancer [PDF]
DNA Repair, 2016 Non-small cell lung cancers (NSCLC) are commonly treated with a platinum-based chemotherapy such as cisplatin (CDDP) in combination with ionizing radiation (IR). Although clinical trials have demonstrated that the combination of CDDP and IR appear to be synergistic in terms of therapeutic efficacy, the mechanism of synergism remains largely ...
Sears, Catherine R. +4 more
openaire +3 more sources
“A DNA Damage Response (DDR) –independent Role for the Ataxia-Telangiectasia Mutated (ATM) Gene Product" [PDF]
, 2010 Ataxia-Telangiectasia (A-T) is a recessive hereditary syndrome characterized by cerebellar degeneration, telangiectasia, precocious aging, immunodeficiency, cancer predisposition and insulin-resistant diabetes. A-T is caused by defects in Ataxia-Telagiectasia Mutated (Atm) gene.
Palazzo, Luca
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Identifying a role for Ciz1 in the DNA damage response [PDF]
, 2011 In proliferating cells, cell cycle arrest and DNA repair are induced upon detection of DNA damage. The DNA damage response (DDR) to double strand DNA breaks is mediated by phosphatidylinositol 3-kinase-like protein kinases (PIKKs), which propagate DDR ...
Roper, Katherine
core +6 more sources
Functional characterization of novel DNA Damage Response (DDR) genes [PDF]
, 2019 Our cells have evolved to deal with thousands of DNA damage events that occur every day, activating the DNA Damage Response (DDR) network. DDR is a complex mechanism that leads to cell-cycle arrest, regulation of DNA replication, repair or bypass of DNA damage.
Monogiou Eirini-Anastasia +1 more
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DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts. [PDF]
, 2002 Alkylating agents, such as methyl methanesulfonate (MMS), damage DNA and activate the DNA damage checkpoint. Although many of the checkpoint proteins that transduce damage signals have been identified and characterized, the mechanism that senses the ...
Lindsay, Howard D. +3 more
core +5 more sources
DNA damage response(DDR): a link between cellular senescence and human cytomegalovirus
Virology Journal, 2023 AbstractThe DNA damage response (DDR) is a signaling cascade that is triggered by DNA damage, involving the halting of cell cycle progression and repair. It is a key event leading to senescence, which is characterized by irreversible cell cycle arrest and the senescence-associated secretory phenotype (SASP) that includes the expression of inflammatory ...
Xinna Wu +3 more
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mBio, 2020 The DNA damage response (DDR) is a signaling cascade that is vital to ensuring the fidelity of the host genome in the presence of genotoxic stress.
Donna Li +4 more
doaj +1 more source
DNA Damage Response (DDR) and DNA Repair
International Journal of Molecular Sciences, 2022 The first aim of cell division is to pass the genetic material, intact and unchanged, to the next generation [...]
openaire +3 more sources