Why Human Papillomaviruses Activate the DNA Damage Response (DDR) and How Cellular and Viral Replication Persists in the Presence of DDR Signaling. [PDF]
Viruses, 2017 Human papillomaviruses (HPV) require the activation of the DNA damage response (DDR) in order to undergo a successful life cycle. This activation presents a challenge for the virus and the infected cell: how does viral and host replication proceed in the presence of a DDR that ordinarily arrests replication; and how do HPV16 infected cells retain the ...
Bristol ML, Das D, Morgan IM.
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DNA Damage Response (DDR) and DNA Repair. [PDF]
Int J Mol Sci, 2022 The first aim of cell division is to pass the genetic material, intact and unchanged, to the next generation [...]
Vernì F.
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DNA damage response(DDR): a link between cellular senescence and human cytomegalovirus. [PDF]
Virol J, 2023 AbstractThe DNA damage response (DDR) is a signaling cascade that is triggered by DNA damage, involving the halting of cell cycle progression and repair. It is a key event leading to senescence, which is characterized by irreversible cell cycle arrest and the senescence-associated secretory phenotype (SASP) that includes the expression of inflammatory ...
Wu X, Zhou X, Wang S, Mao G.
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From yeast to humans: Understanding the biology of DNA Damage Response (DDR) kinases. [PDF]
Genet Mol Biol, 2019 The DNA Damage Response (DDR) is a complex network of biological processes that protect cells from accumulating aberrant DNA structures, thereby maintaining genomic stability and, as a consequence, preventing the development of cancer and other diseases.
Cussiol JRR, Soares BL, Oliveira FMB.
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miR-211 facilitates platinum chemosensitivity by blocking the DNA damage response (DDR) in ovarian cancer. [PDF]
Cell Death Dis, 2019 AbstractThe DNA damage response (DDR) is one of the most important mechanisms of platinum resistance in ovarian cancer. Some miRNAs have been identified to be involved in the regulatory network of DDR, thus the abnormal expression of miRNAs might affect platinum chemosensitivity in ovarian cancer.
Wang T +21 more
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Wip1 downregulation conserves truncated DNA damage response (DDR) in mitosis [PDF]
Cell Cycle, 2013 Comment on: Macurek L, et al. Cell Cycle 2012; 12:251-62.
Vaz, B, Ramadan, K
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The DNA damage response (DDR) is induced by the C9orf72 repeat expansion in amyotrophic lateral sclerosis [PDF]
Human Molecular Genetics, 2017 Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease affecting motor neurons. Hexanucleotide (GGGGCC) repeat expansions in a non-coding region of C9orf72 are the major cause of familial ALS and frontotemporal dementia (FTD) worldwide. The C9orf72 repeat expansion undergoes repeat-associated non-ATG (RAN) translation to
Manal A, Farg +4 more
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DNA damage response (DDR) and senescence: shuttled inflamma-miRNAs on the stage of inflamm-aging. [PDF]
Oncotarget, 2015 A major issue in aging research is how cellular phenomena affect aging at the systemic level. Emerging evidence suggests that DNA damage response (DDR) signaling is a key mechanism linking DNA damage accumulation, cell senescence, and organism aging. DDR activation in senescent cells promotes acquisition of a proinflammatory secretory phenotype (SASP),
Olivieri F +6 more
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DNA damage response (DDR) via NKX3.1 expression in prostate cells
The Journal of Steroid Biochemistry and Molecular Biology, 2014 It has been reported that NKX3.1 an androgen-regulated homeobox gene restricted to prostate and testicular tissues, encodes a homeobox protein, which transcriptionally regulates oxidative damage responses and enhances topoisomerase I re-ligation by a direct interaction with the ATM protein in prostate cells.
Burcu Erbaykent-Tepedelen +3 more
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DNA damage response (DDR) pathway engagement in cisplatin radiosensitization of non-small cell lung cancer [PDF]
DNA Repair, 2016 Non-small cell lung cancers (NSCLC) are commonly treated with a platinum-based chemotherapy such as cisplatin (CDDP) in combination with ionizing radiation (IR). Although clinical trials have demonstrated that the combination of CDDP and IR appear to be synergistic in terms of therapeutic efficacy, the mechanism of synergism remains largely ...
Sears, Catherine R. +4 more
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