Results 31 to 40 of about 7,534,152 (213)

The DNA damage response (DDR) is induced by the C9orf72 repeat expansion in amyotrophic lateral sclerosis [PDF]

Human Molecular Genetics, 2017
Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease affecting motor neurons. Hexanucleotide (GGGGCC) repeat expansions in a non-coding region of C9orf72 are the major cause of familial ALS and frontotemporal dementia (FTD) worldwide. The C9orf72 repeat expansion undergoes repeat-associated non-ATG (RAN) translation to
Manal A, Farg, Anna, Konopka, Kai Ying, Soo, Daisuke, Ito, Julie D, Atkin   +4 more
openaire   +2 more sources

DNA damage responses in the context of the cell division cycle [PDF]

, 2010
During my PhD, I have investigated aspects of the DNA damage response (DDR) in the context of three different cellular scenarios: DNA damage signalling in response to double-strand breaks during mitosis, coordination of DNA replication with DNA damage ...

core   +2 more sources

The role of DNA damage repair (DDR) system in response to immune checkpoint inhibitor (ICI) therapy

Journal of Experimental & Clinical Cancer Research, 2022
AbstractAs our understanding of the mechanisms of cancer treatment has increased, a growing number of studies demonstrate pathways through which DNA damage repair (DDR) affects the immune system. At the same time, the varied response of patients to immune checkpoint blockade (ICB) therapy has prompted the discovery of various predictive biomarkers and ...
Congqi Shi, Kaiyu Qin, Anqi Lin, Aimin Jiang, Quan Cheng, Zaoqu Liu, Jian Zhang, Peng Luo   +7 more
openaire   +3 more sources

DNA damage induced during mitosis undergoes DNA repair synthesis.

PLoS ONE, 2020
Understanding the mitotic DNA damage response (DDR) is critical to our comprehension of cancer, premature aging and developmental disorders which are marked by DNA repair deficiencies.
Veronica Gomez Godinez, Sami Kabbara, Adria Sherman, Tao Wu, Shirli Cohen, Xiangduo Kong, Jose Luis Maravillas-Montero, Zhixia Shi, Daryl Preece, Kyoko Yokomori, Michael W Berns   +10 more
doaj   +1 more source

The Adenovirus E4orf4 Protein Provides a Novel Mechanism for Inhibition of the DNA Damage Response. [PDF]

PLoS Pathogens, 2016
The DNA damage response (DDR) is a conglomerate of pathways designed to detect DNA damage and signal its presence to cell cycle checkpoints and to the repair machinery, allowing the cell to pause and mend the damage, or if the damage is too severe, to ...
Anna Brestovitsky, Keren Nebenzahl-Sharon, Peter Kechker, Rakefet Sharf, Tamar Kleinberger   +4 more
doaj   +1 more source

miR-211 facilitates platinum chemosensitivity by blocking the DNA damage response (DDR) in ovarian cancer [PDF]

Cell Death & Disease, 2019
AbstractThe DNA damage response (DDR) is one of the most important mechanisms of platinum resistance in ovarian cancer. Some miRNAs have been identified to be involved in the regulatory network of DDR, thus the abnormal expression of miRNAs might affect platinum chemosensitivity in ovarian cancer.
Tianzhen Wang, Dapeng Hao, Shucai Yang, Jianhui Ma, Weiwei Yang, Yuanyuan Zhu, Mingjiao Weng, Xiang An, Xuefei Wang, Yafei Li, Di Wu, Jing Tang, Chao Yang, Yan He, Lei Zhang, Xiaoming Jin, Guangyu Wang, Zhiwei Li, Tongsen Zheng, Hongxue Meng, Yukuan Feng, Xiaobo Li   +21 more
openaire   +2 more sources

DNA single-strand break-induced DNA damage response causes heart failure

Nature Communications, 2017
DNA damage response (DDR) is activated in cardiomyocytes of the failing heart, but the type of DNA damage leading to DDR is unclear. Higoet al. show that in mice heart failure is caused in part by unrepaired DNA single-strand breaks in cardiomyocytes ...
Tomoaki Higo, Atsuhiko T. Naito, Tomokazu Sumida, Masato Shibamoto, Katsuki Okada, Seitaro Nomura, Akito Nakagawa, Toshihiro Yamaguchi, Taku Sakai, Akihito Hashimoto, Yuki Kuramoto, Masamichi Ito, Shungo Hikoso, Hiroshi Akazawa, Jong-Kook Lee, Ichiro Shiojima, Peter J. McKinnon, Yasushi Sakata, Issei Komuro   +18 more
doaj   +1 more source

Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium

Cell Reports, 2019
Summary: DNA damage activates checkpoints that limit the replicative potential of stem cells, including differentiation. These checkpoints protect against cancer development but also promote tissue aging.
Kayla M. Gross, Wenhui Zhou, Jerrica L. Breindel, Jian Ouyang, Dexter X. Jin, Ethan S. Sokol, Piyush B. Gupta, Kathryn Huber, Lee Zou, Charlotte Kuperwasser   +9 more
doaj   +1 more source

DNA damage response and spindle assembly checkpoint function throughout the cell cycle to ensure genomic integrity. [PDF]

PLoS Genetics, 2015
Errors in replication or segregation lead to DNA damage, mutations, and aneuploidies. Consequently, cells monitor these events and delay progression through the cell cycle so repair precedes division.
Katherine S Lawrence, Thinh Chau, JoAnne Engebrecht   +2 more
doaj   +1 more source

DNA damage response and Autophagy: a meaningful partnership

Frontiers in Genetics, 2016
Autophagy and the DNA damage response (DDR) are biological processes essential for cellular and organismal homeostasis. Herein we summarize and discuss emerging evidence linking DDR to autophagy. We highlight published data suggesting that autophagy is
ARISTIDES G ELIOPOULOS, ARISTIDES G ELIOPOULOS, Sophia Havaki, Vassilis G Gorgoulis, Vassilis G Gorgoulis, Vassilis G Gorgoulis   +5 more
doaj   +1 more source