Results 31 to 40 of about 106,021 (225)

Triple kill: DDR inhibitors, radiotherapy and immunotherapy leave cancer cells with no escape

Acta Biochimica et Biophysica Sinica, 2022
Radiotherapy (RT) has been widely used in the clinical treatment of cancers, but radiotherapy resistance (RR) leads to RT failure, tumor recurrence and metastasis.
Qiu Yuyue, Hu Xinru, Zeng Xiaoping, Wang Hongmei   +3 more
doaj   +1 more source

Differential DNA Damage Response of Peripheral Blood Lymphocyte Populations

Frontiers in Immunology, 2021
DNA damage occurs constantly in every cell triggered by endogenous processes of replication and metabolism, and external influences such as ionizing radiation and intercalating chemicals.
Kerstin Felgentreff, Catharina Schuetz, Ulrich Baumann, Christian Klemann, Dorothee Viemann, Simona Ursu, Eva-Maria Jacobsen, Klaus-Michael Debatin, Ansgar Schulz, Manfred Hoenig, Manfred Hoenig, Klaus Schwarz, Klaus Schwarz   +12 more
doaj   +1 more source

Not All DDRs Are Created Equal: Non-Canonical DNA Damage Responses [PDF]

Cell, 2015
It is commonly assumed that there is a single canonical DNA damage response (DDR) that protects cells from various types of double-strand breaks and that its activation occurs via recognition of DNA ends by the DDR machinery. Recent work suggests that both assumptions may be oversimplifications.
Burgess, Rebecca C., Misteli, Tom
openaire   +2 more sources

Chromatin Ubiquitination Guides DNA Double Strand Break Signaling and Repair

Frontiers in Cell and Developmental Biology, 2022
Chromatin is the context for all DNA-based molecular processes taking place in the cell nucleus. The initial chromatin structure at the site of the DNA damage determines both, lesion generation and subsequent activation of the DNA damage response (DDR ...
Ksenia G. Kolobynina, Alexander Rapp, M. Cristina Cardoso   +2 more
doaj   +1 more source

HIV Vpr Modulates the Host DNA Damage Response at Two Independent Steps to Damage DNA and Repress Double-Strand DNA Break Repair

mBio, 2020
The DNA damage response (DDR) is a signaling cascade that is vital to ensuring the fidelity of the host genome in the presence of genotoxic stress.
Donna Li, Andrew Lopez, Carina Sandoval, Randilea Nichols Doyle, Oliver I. Fregoso   +4 more
doaj   +1 more source

Targeting DNA damage response deficiency in the treatment of breast cancer [PDF]

Zhongguo aizheng zazhi, 2022
DNA damage response (DDR) deficiency has been one of the emerging targets in treating breast cancer in recent years. The DDR pathway is essential for the identification, signal transduction and repair of DNA damage.
Yizi JIN, Mingxi LIN, Jian ZHANG
doaj   +2 more sources

DNA Damage Response and Immune Defence: Links and Mechanisms

Frontiers in Genetics, 2016
DNA damage plays a causal role in numerous human pathologies including cancer, premature aging and chronic inflammatory conditions. In response to genotoxic insults, the DNA damage response (DDR) orchestrates DNA damage checkpoint activation and ...
Björn Schumacher, Rania Nakad
doaj   +1 more source

Treatment of Sulfur Mustard Corneal Injury by Augmenting the DNA Damage Response (DDR): A Novel Approach. [PDF]

J Pharmacol Exp Ther
Sulfur mustard (SM) is a highly reactive organic chemical has been used as a chemical warfare agent and terrorist threat since World War I. The cornea is highly sensitive to SM toxicity and exposure to low vapor doses can cause incapacitating acute injuries.
Shalwitz R, Day T, Ruehlmann AK, Julio L, Gordon S, Vandeuren A, Nelson M, Lyman M, Kelly K, Altvater A, Ondeck C, O'Brien S, Hamilton T, Hanson RL, Wayman K, Miller A, Shalwitz I, Batchelor E, McNutt P.   +18 more
europepmc   +3 more sources

Activation of DNA Damage Response Signaling by Condensed Chromatin

Cell Reports, 2014
Summary: The DNA damage response (DDR) occurs in the context of chromatin, and architectural features of chromatin have been implicated in DNA damage signaling and repair. Whereas a role of chromatin decondensation in the DDR is well established, we show
Rebecca C. Burgess, Bharat Burman, Michael J. Kruhlak, Tom Misteli   +3 more
doaj   +1 more source

Imaging the Response to DNA Damage in Heterochromatin Domains

Frontiers in Cell and Developmental Biology, 2022
The eukaryotic genome is assembled in a nucleoprotein complex called chromatin, whose organization markedly influences the repair of DNA lesions. For instance, compact chromatin states, broadly categorized as heterochromatin, present a challenging ...
Audrey Chansard, Enrico Pobega, Pierre Caron, Sophie E. Polo   +3 more
doaj   +1 more source