Results 51 to 60 of about 106,021 (225)
The Adenovirus E4orf4 Protein Provides a Novel Mechanism for Inhibition of the DNA Damage Response. [PDF]
PLoS Pathogens, 2016 The DNA damage response (DDR) is a conglomerate of pathways designed to detect DNA damage and signal its presence to cell cycle checkpoints and to the repair machinery, allowing the cell to pause and mend the damage, or if the damage is too severe, to ...
Anna Brestovitsky +4 more
doaj +1 more source
A new wave of innovations within the DNA damage response
Signal Transduction and Targeted Therapy, 2023 Genome instability has been identified as one of the enabling hallmarks in cancer. DNA damage response (DDR) network is responsible for maintenance of genome integrity in cells.
Qi Li +5 more
semanticscholar +1 more source
DNA single-strand break-induced DNA damage response causes heart failure
Nature Communications, 2017 DNA damage response (DDR) is activated in cardiomyocytes of the failing heart, but the type of DNA damage leading to DDR is unclear. Higoet al. show that in mice heart failure is caused in part by unrepaired DNA single-strand breaks in cardiomyocytes ...
Tomoaki Higo +18 more
doaj +1 more source
DNA damage response and Autophagy: a meaningful partnership
Frontiers in Genetics, 2016 Autophagy and the DNA damage response (DDR) are biological processes essential for cellular and organismal homeostasis. Herein we summarize and discuss emerging evidence linking DDR to autophagy. We highlight published data suggesting that autophagy is
ARISTIDES G ELIOPOULOS +5 more
doaj +1 more source
DNA damage response and spindle assembly checkpoint function throughout the cell cycle to ensure genomic integrity. [PDF]
PLoS Genetics, 2015 Errors in replication or segregation lead to DNA damage, mutations, and aneuploidies. Consequently, cells monitor these events and delay progression through the cell cycle so repair precedes division.
Katherine S Lawrence +2 more
doaj +1 more source
Aging, 2011 By activating the ataxia telangiectasia mutated (ATM)-mediated DNA Damage Response (DDR), the AMPK agonist metformin might sensitize cells against further damage, thus mimicking the precancerous stimulus that induces an intrinsic barrier against ...
J. Menéndez +6 more
semanticscholar +1 more source
Camonsertib in DNA damage response-deficient advanced solid tumors: phase 1 trial results
Nature Medicine, 2023 In patients with DNA damage response-deficient solid tumors, the oral ATR kinase inhibitor camonsertib was well tolerated; a recommended phase 2 dose was identified; and encouraging anti-tumor activity was observed, with the highest response rate ...
T. Yap +24 more
semanticscholar +1 more source
Nature Communications, 2017 The DNA damage response (DDR) involves site-specific small non-coding RNAs. Here the authors show that telomere dysfunction induces transcription of telomeric DNA damage response RNAs that are necessary for DDR activation, which can be specifically muted
Francesca Rossiello +7 more
doaj +1 more source
Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium
Cell Reports, 2019 Summary: DNA damage activates checkpoints that limit the replicative potential of stem cells, including differentiation. These checkpoints protect against cancer development but also promote tissue aging.
Kayla M. Gross +9 more
doaj +1 more source
Function and Molecular Mechanism of the DNA Damage Response in Immunity and Cancer Immunotherapy
Frontiers in Immunology, 2021 The DNA damage response (DDR) is an organized network of multiple interwoven components evolved to repair damaged DNA and maintain genome fidelity.
Zu Ye +4 more
doaj +1 more source