Results 71 to 80 of about 106,021 (225)

Crosstalk between Wnt/β-catenin signaling pathway and DNA damage response in cancer: a new direction for overcoming therapy resistance

Frontiers in Pharmacology, 2023
Wnt signaling plays an important role in regulating the biological behavior of cancers, and many drugs targeting this signaling have been developed. Recently, a series of research have revealed that Wnt signaling could regulate DNA damage response (DDR ...
Xixia Zhang, Xiaofeng Yu
semanticscholar   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

The role of truncated p53 isoforms in the DNA damage response.

Biochimica et biophysica acta. Reviews on cancer, 2023
The tumour suppressor p53 is activated following genotoxic stress and regulates the expression of target genes involved in the DNA damage response (DDR).
Luiza S. Reinhardt, K. Groen, C. Newton, K. Avery-Kiejda   +3 more
semanticscholar   +1 more source

Implications of DNA damage response and immunotherapy in tumor therapy

Cell Communication and Signaling
Tumorigenesis is closely related to defects in DNA damage response (DDR), which plays an important role in maintaining genomic integrity. The DDR process includes DNA damage recognition, cell cycle checkpoint pathway activation, and DNA damage repair. On
Wenqing Li, Binghang Li, Chang Cai, Jie Chen, Yiqiu Li, Rongrui Liang, Jing Zhao   +6 more
doaj   +1 more source

A score of DNA damage repair pathway with the predictive ability for chemotherapy and immunotherapy is strongly associated with immune signaling pathway in pan-cancer

Frontiers in Immunology, 2022
DNA damage repair (DDR) is critical in maintaining normal cellular function and genome integrity and is associated with cancer risk, progression, and therapeutic response.
Ke Ding, Youhua He, Jinfen Wei, Shuying Fu, Jiajian Wang, Zixi Chen, Haibo Zhang, Yimo Qu, Keying Liang, Xiaocheng Gong, Li Qiu, Dong Chen, Botao Xiao, Hongli Du   +13 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

A multi-scale map of protein assemblies in the DNA damage response

Cell Systems, 2023
SUMMARY The DNA damage response (DDR) ensures error-free DNA replication and transcription and is disrupted in numerous diseases. An ongoing challenge is to determine the proteins orchestrating DDR and their organization into complexes, including ...
A. Kratz, Minkyu Kim, M. Kelly, Fan Zheng, C. Koczor, Jianfeng Li, K. Ono, Yue Qin, C. Churas, J. Chen, R. Pillich, Jisoo Park, Maya Modak, Rachel Collier, Katherine Licon, Dexter Pratt, R. Sobol, N. Krogan, T. Ideker   +18 more
semanticscholar   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Targeting the DNA Damage Response for Cancer Therapy

International Journal of Molecular Sciences, 2023
Over the course of long-term evolution, cells have developed intricate defense mechanisms in response to DNA damage; these mechanisms play a pivotal role in maintaining genomic stability.
Ruoxi Wang, Yating Sun, Chunshuang Li, Yaoyao Xue, Xueqing Ba   +4 more
semanticscholar   +1 more source

A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation

BMC Cancer, 2011
Background The mammalian DNA-damage response (DDR) has evolved to protect genome stability and maximize cell survival following DNA-damage. One of the key regulators of the DDR is p53, itself tightly regulated by MDM2. Following double-strand DNA breaks (
Kumar Sonia, Valentine Jane M, Moumen Abdeladim   +2 more
doaj   +1 more source