Results 61 to 70 of about 106,021 (225)
The DNA Damage Response and Inflammation in Cancer.
Cancer Discovery, 2023 Genomic stability in normal cells is crucial to avoid oncogenesis. Accordingly, multiple components of the DNA damage response (DDR) operate as bona fide tumor suppressor proteins by preserving genomic stability, eliciting the demise of cells with ...
V. Klapp +5 more
semanticscholar +1 more source
The Role of the DNA Damage Response throughout the Papillomavirus Life Cycle
Viruses, 2015 The DNA damage response (DDR) maintains genomic integrity through an elaborate network of signaling pathways that sense DNA damage and recruit effector factors to repair damaged DNA.
Caleb C. McKinney +2 more
doaj +1 more source
The DNA damage response in the chromatin context: A coordinated process.
Current Opinion in Cell Biology, 2023 In the cell nucleus, DNA damage signaling and repair machineries operate on a chromatin substrate, the integrity of which is critical for cell function and viability. Here, we review recent advances in deciphering the tight coordination between chromatin
Juliette Dabin, M. Mori, S. Polo
semanticscholar +1 more source
Seneca Valley virus infection exploits DNA damage response to facilitate viral replication
Journal of VirologySeneca Valley virus (SVV) is an emerging pathogen that causes severe vesicular diseases in swine, posing a significant threat to the global pork industry.
Jiangwei Song +7 more
doaj +1 more source
The DNA Damage Response: Making it safe to play with knives
Molecules and Cells, 2010 Damage to our genetic material is an ongoing threat to both our ability to faithfully transmit genetic information to our offspring as well as our own survival. To respond to these threats, eukaryotes have evolved the DNA Damage Response (DDR).
Alberto Ciccia, S. Elledge
semanticscholar +1 more source
PD-1/PD-L1 and DNA Damage Response in Cancer
Cells, 2023 The application of immunotherapy for cancer treatment is rapidly becoming more widespread. Immunotherapeutic agents are frequently combined with various types of treatments to obtain a more durable antitumor clinical response in patients who have ...
M. Kciuk +6 more
semanticscholar +1 more source
MRN- and 9-1-1-Independent Activation of the ATR-Chk1 Pathway during the Induction of the Virulence Program in the Phytopathogen Ustilago maydis. [PDF]
PLoS ONE, 2015 DNA damage response (DDR) leads to DNA repair, and depending on the extent of the damage, to further events, including cell death. Evidence suggests that cell differentiation may also be a consequence of the DDR.
María Tenorio-Gómez +2 more
doaj +1 more source
Current Oncology, 2023 Ionizing radiation (IR) dose, dose rate, and linear energy transfer (LET) determine cellular DNA damage quality and quantity. High-LET heavy ions are prevalent in the deep space environment and can deposit a much greater fraction of total energy in a ...
Kamendra Kumar +4 more
semanticscholar +1 more source
The DNA damage response in immunotherapy and radiation
Advances in Radiation Oncology, 2018 Purpose: Deficiencies in DNA damage repair (DDR) and response represent a common alteration in tumors, and exploitation of this feature using therapeutics has become more prominent.
Robert M. Samstein, MD, PhD +1 more
doaj +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source