Results 41 to 50 of about 106,021 (225)

The Role of Malfunctioning DNA Damage Response (DDR) in Brain Degeneration

Opera Medica et Physiologica, 2016
Maintenance of genome stability in the face of DNA damage is essential for cellular homeostasis and prevention of cancer and brain degeneration. The DNA damage response (DDR) is a complex response that is rapidly activated when a DNA lesion occurs in chromosomal DNA.
TALYA SHACHAM, RONIT GALRON, OFER BIHARI, SIVAN KANNER, ARI BARZILAI   +4 more
openaire   +2 more sources

New Insights into Checkpoint Kinase 1 (Chk1) in the DNA Damage Response (DDR) Signaling Network: Rationale for Employing Chk1 Inhibitors in Cancer Therapeutics

Clinical Cancer Research, 2010
The DNA damage response (DDR) represents a complex network of multiple signaling pathways involving cell cycle checkpoints, DNA repair, transcriptional programs, and apoptosis, through which cells maintain genomic integrity following various endogenous ...
Yun Dai, S. Grant
semanticscholar   +1 more source

SIRT1 Involved in the Regulation of Alternative Splicing Affects the DNA Damage Response in Neural Stem Cells

Cellular Physiology and Biochemistry, 2018
Background/Aims: Alternative splicing and DNA damage exhibit cross-regulation, with not only DNA damage inducing changes in alternative splicing, but alternative splicing itself possibly modulating the DNA damage response (DDR).
Guangming Wang, Fangce Wang, Jie Ren, Yue Qiu, Wenjun Zhang, Shane Gao, Danjing Yang, Zhigang Wang, Aibin Liang, Zhengliang Gao, Jun Xu   +10 more
doaj   +1 more source

CCN2 Aggravates the Immediate Oxidative Stress–DNA Damage Response following Renal Ischemia–Reperfusion Injury

Antioxidants, 2021
AKI, due to the fact of altered oxygen supply after kidney transplantation, is characterized by renal ischemia–reperfusion injury (IRI). Recent data suggest that AKI to CKD progression may be driven by cellular senescence evolving from prolonged DNA ...
Floris A. Valentijn, Sebastiaan N. Knoppert, Georgios Pissas, Raúl R. Rodrigues-Diez, Laura Marquez-Exposito, Roel Broekhuizen, Michal Mokry, Lennart A. Kester, Lucas L. Falke, Roel Goldschmeding, Marta Ruiz-Ortega, Theodoros Eleftheriadis, Tri Q. Nguyen   +12 more
doaj   +1 more source

Regulation of the DNA Damage Response by Ubiquitin Conjugation

Frontiers in Genetics, 2015
In response to DNA damage, cells activate a highly conserved and complex kinase-based signaling network, commonly referred to as the DNA damage response (DDR), to safeguard genomic integrity.
Kerstin eBrinkmann, Kerstin eBrinkmann, Michael eSchell, Michael eSchell, Thorsten eHoppe, Thorsten eHoppe, Hamid eKashkar, Hamid eKashkar   +7 more
doaj   +1 more source

DNA damage response inhibition‐based combination therapies in cancer treatment: Recent advances and future directions

Aging and Cancer, 2022
DNA molecules are subject to various lesions that can be detrimental to the cells. DNA damage response (DDR) pathways encompass a variety of mechanisms that cells employ in response to DNA damage.
Tianen Chen, Suparat Tongpeng, Ziyi Lu, Win Topatana, Sarun Juengpanich, Shijie Li, Jiahao Hu, Jiasheng Cao, Cheeshin Lee, Yitong Tian, Mingyu Chen, Xiujun Cai   +11 more
doaj   +1 more source

DNA damage induced during mitosis undergoes DNA repair synthesis.

PLoS ONE, 2020
Understanding the mitotic DNA damage response (DDR) is critical to our comprehension of cancer, premature aging and developmental disorders which are marked by DNA repair deficiencies.
Veronica Gomez Godinez, Sami Kabbara, Adria Sherman, Tao Wu, Shirli Cohen, Xiangduo Kong, Jose Luis Maravillas-Montero, Zhixia Shi, Daryl Preece, Kyoko Yokomori, Michael W Berns   +10 more
doaj   +1 more source

The DNA Damage Response (DDR) landscape of endometrial cancer defines discrete disease subtypes and reveals therapeutic opportunities. [PDF]

NAR Cancer, 2023
Abstract Genome maintenance is an enabling characteristic that allows neoplastic cells to tolerate the inherent stresses of tumorigenesis and evade therapy-induced genotoxicity. Neoplastic cells also deploy many mis-expressed germ cell proteins termed Cancer Testes Antigens (CTAs) to promote genome maintenance and survival.
Zhang X, Joseph S, Wu D, Bowser JL, Vaziri C.   +4 more
europepmc   +4 more sources

Partial Sleep Deprivation Activates the DNA Damage Response (DDR) and the Senescence-Associated Secretory Phenotype (SASP) in Aged Adult Humans

Brain, behavior, and immunity, 2015
Age-related disease risk has been linked to short sleep duration and sleep disturbances; however, the specific molecular pathways linking sleep loss with diseases of aging are poorly defined.
J. Carroll, S. Cole, T. Seeman, E. Breen, Tuff Witarama, J. Arevalo, J. Ma, M. Irwin   +7 more
semanticscholar   +1 more source

Impact of DNA Damage Response and Repair (DDR) Gene Mutations on Efficacy of PD-(L)1 Immune Checkpoint Inhibition in Non–Small Cell Lung Cancer

Clinical Cancer Research, 2020
Purpose: DNA damage response and repair (DDR) gene alterations are associated with increased tumor-infiltrating lymphocytes, higher genomic instability, and higher tumor mutational burden (TMB) in cancer.
B. Ricciuti, G. Recondo, Liam F. Spurr, Yvonne Y. Li, G. Lamberti, D. Venkatraman, R. Umeton, A. Cherniack, M. Nishino, L. Sholl, G. Shapiro, M. Awad, M. Cheng   +12 more
semanticscholar   +1 more source