Results 41 to 50 of about 7,534,152 (213)

Phosphorylation events surrounding the DNA damage response in "Saccharomyces cerevisiae" [PDF]

, 2007
Protein phosphorylation mediated by checkpoint kinases is crucial for the cellular response to DNA damage. The sensor kinases Mec1 and Tel1 initiate the checkpoint signaling cascade by directly activating the checkpoint effector kinase Rad53.
Schleker, Thomas Andreas
core   +1 more source

Function and Molecular Mechanism of the DNA Damage Response in Immunity and Cancer Immunotherapy

Frontiers in Immunology, 2021
The DNA damage response (DDR) is an organized network of multiple interwoven components evolved to repair damaged DNA and maintain genome fidelity.
Zu Ye, Yin Shi, Yin Shi, Susan P. Lees-Miller, John A. Tainer   +4 more
doaj   +1 more source

Seneca Valley virus infection exploits DNA damage response to facilitate viral replication

Journal of Virology
Seneca Valley virus (SVV) is an emerging pathogen that causes severe vesicular diseases in swine, posing a significant threat to the global pork industry.
Jiangwei Song, Zijian Li, Jingjing Yang, Ruiyi Ma, Dan Wang, Rong Quan, Xuexia Wen, Jue Liu   +7 more
doaj   +1 more source

The Role of the DNA Damage Response throughout the Papillomavirus Life Cycle

Viruses, 2015
The DNA damage response (DDR) maintains genomic integrity through an elaborate network of signaling pathways that sense DNA damage and recruit effector factors to repair damaged DNA.
Caleb C. McKinney, Katherine L. Hussmann, Alison A. McBride   +2 more
doaj   +1 more source

MRN- and 9-1-1-Independent Activation of the ATR-Chk1 Pathway during the Induction of the Virulence Program in the Phytopathogen Ustilago maydis. [PDF]

PLoS ONE, 2015
DNA damage response (DDR) leads to DNA repair, and depending on the extent of the damage, to further events, including cell death. Evidence suggests that cell differentiation may also be a consequence of the DDR.
María Tenorio-Gómez, Carmen de Sena-Tomás, Jose Pérez-Martín   +2 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

The DNA damage response in immunotherapy and radiation

Advances in Radiation Oncology, 2018
Purpose: Deficiencies in DNA damage repair (DDR) and response represent a common alteration in tumors, and exploitation of this feature using therapeutics has become more prominent.
Robert M. Samstein, MD, PhD, Nadeem Riaz, MD   +1 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

A score of DNA damage repair pathway with the predictive ability for chemotherapy and immunotherapy is strongly associated with immune signaling pathway in pan-cancer

Frontiers in Immunology, 2022
DNA damage repair (DDR) is critical in maintaining normal cellular function and genome integrity and is associated with cancer risk, progression, and therapeutic response.
Ke Ding, Youhua He, Jinfen Wei, Shuying Fu, Jiajian Wang, Zixi Chen, Haibo Zhang, Yimo Qu, Keying Liang, Xiaocheng Gong, Li Qiu, Dong Chen, Botao Xiao, Hongli Du   +13 more
doaj   +1 more source

DNA damage response (DDR) and senescence: shuttled inflamma-miRNAs on the stage of inflamm-aging

Oncotarget, 2015
A major issue in aging research is how cellular phenomena affect aging at the systemic level. Emerging evidence suggests that DNA damage response (DDR) signaling is a key mechanism linking DNA damage accumulation, cell senescence, and organism aging. DDR activation in senescent cells promotes acquisition of a proinflammatory secretory phenotype (SASP),
Olivieri, Fabiola, Albertini, Maria Cristina, Orciani, Monia, Ceka, Artan, CRICCA, MONICA, Procopio, Antonio Domenico, BONAFE', MASSIMILIANO   +6 more
openaire   +4 more sources