Results 21 to 30 of about 106,021 (225)

The role of DNA damage repair (DDR) system in response to immune checkpoint inhibitor (ICI) therapy

Journal of Experimental & Clinical Cancer Research, 2022
AbstractAs our understanding of the mechanisms of cancer treatment has increased, a growing number of studies demonstrate pathways through which DNA damage repair (DDR) affects the immune system. At the same time, the varied response of patients to immune checkpoint blockade (ICB) therapy has prompted the discovery of various predictive biomarkers and ...
Congqi Shi, Kaiyu Qin, Anqi Lin, Aimin Jiang, Quan Cheng, Zaoqu Liu, Jian Zhang, Peng Luo   +7 more
openaire   +4 more sources

Determining the Potential of DNA Damage Response (DDR) Inhibitors in Cervical Cancer Therapy. [PDF]

Cancers (Basel), 2022
Cisplatin-based chemo-radiotherapy (CRT) is the standard treatment for advanced cervical cancer (CC) but the response rate is poor (46–72%) and cisplatin is nephrotoxic. Therefore, better treatment of CC is urgently needed. We have directly compared, for the first time, the cytotoxicity of four DDR inhibitors (rucaparib/PARPi, VE-821/ATRi, PF-477736 ...
Saha S, Rundle S, Kotsopoulos IC, Begbie J, Howarth R, Pappworth IY, Mukhopadhyay A, Kucukmetin A, Marchbank KJ, Curtin N.   +9 more
europepmc   +5 more sources

Distinct characteristics of the DNA damage response in mammalian oocytes

Experimental and Molecular Medicine
DNA damage is a critical threat that poses significant challenges to all cells. To address this issue, cells have evolved a sophisticated molecular and cellular process known as the DNA damage response (DDR).
Jiyeon Leem, Crystal Lee, Da Yi Choi, Jeong Su Oh   +3 more
doaj   +2 more sources

Methodological Landscape of DNA Damage Response Detection: From Conventional Assays to Future Innovations [PDF]

Current Issues in Molecular Biology
All living organisms possess a DNA damage response (DDR) that is important for genetic evolution. Cells have developed comprehensive mechanisms for addressing DNA damage, collectively called the DNA damage response and repair.
Yan Xi, Xinchen Yan, Jiahao Liu, Siqi Li, Xinyang Zhang, Yiwen Hou, Minjie Chu, Minfeng Yang   +7 more
doaj   +2 more sources

DNA Damage Response (DDR) Is Associated With Treatment-free Remission in Chronic Myeloid Leukemia Patients. [PDF]

Hemasphere, 2023
Malighetti F, Arosio G, Manfroni C, Mauri M, Villa M, Manghisi B, Inzoli E, Rindone G, Zambrotta GPM, Civettini I, Guglielmana V, Ramazzotti D, Giudici G, Bombelli S, Perego R, Piazza R, Mologni L, Gambacorti-Passerini C.   +17 more
europepmc   +4 more sources

A Bioinformatics Approach to Explore MicroRNAs as Tools to Bridge Pathways Between Plants and Animals. Is DNA Damage Response (DDR) a Potential Target Process? [PDF]

Front Plant Sci, 2019
Bellato M, De Marchi D, Gualtieri C, Sauta E, Magni P, Macovei A, Pasotti L.   +6 more
europepmc   +2 more sources

The Interplay between the DNA Damage Response (DDR) Network and the Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway in Multiple Myeloma. [PDF]

Int J Mol Sci
Malamos P, Papanikolaou C, Gavriatopoulou M, Dimopoulos MA, Terpos E, Souliotis VL.   +5 more
europepmc   +2 more sources

The plant‐specific DDR factor SOG1 increases chromatin mobility in response to DNA damage [PDF]

The EMBO Reports, 2022
Homologous recombination (HR) is a conservative DNA repair pathway in which intact homologous sequences are used as a template for repair. How the homology search happens in the crowded space of the cell nucleus is, however, still poorly understood. Here, we measure chromosome and double-strand break (DSB) site mobility in Arabidopsis thaliana, using ...
Anis Meschichi, Lihua Zhao, Svenja Reeck, Charles White, Olivier Da Ines, Adrien Sicard, Frédéric Pontvianne, Stefanie Rosa   +7 more
openaire   +5 more sources

Merkel Cell Polyomavirus and DNA Damage Response (DDR): Transcriptional Analysis of DDR Pathways in the Context of Merkel Cell Carcinoma. [PDF]

Cancers (Basel)
Background/Objectives: Merkel cell polyomavirus (MCPyV) is a ubiquitous virus strictly associated with Merkel cell carcinoma (MCC), a rare and aggressive skin cancer. MCPyV oncogenic properties are associated mainly with early protein expression, integration, and LT truncation.
Messina S, Mallardo D, Ferlosio A, Festino L, Trojaniello C, Di Trolio R, Ciotti M, Ascierto PA, Pietropaolo V, Passerini S.   +9 more
europepmc   +3 more sources

Targeting Mechanisms of the DNA Damage Response (DDR) and DNA Repair by Natural Compounds to Improve cAT-Triggered Tumor Cell Death. [PDF]

Molecules, 2022
Recently, we identified secalonic acid F (SA), 5-epi-nakijiquinone Q (NQ) and 5-epi-ilimaquinone (IQ) as natural compounds (NC) affecting mechanisms of the DNA damage response (DDR). Here, we further characterized their effects on DDR, DNA repair and cytotoxicity if used in mono- and co-treatment with conventional anticancer therapeutics (cAT ...
Aengenvoort J, Sekeres M, Proksch P, Fritz G.   +3 more
europepmc   +4 more sources