Results 21 to 30 of about 7,534,152 (213)
Targeting DNA damage response deficiency in the treatment of breast cancer [PDF]
Zhongguo aizheng zazhi, 2022 DNA damage response (DDR) deficiency has been one of the emerging targets in treating breast cancer in recent years. The DDR pathway is essential for the identification, signal transduction and repair of DNA damage.
Yizi JIN, Mingxi LIN, Jian ZHANG
doaj +2 more sources
DNA Damage Response and Immune Defence: Links and Mechanisms
Frontiers in Genetics, 2016 DNA damage plays a causal role in numerous human pathologies including cancer, premature aging and chronic inflammatory conditions. In response to genotoxic insults, the DNA damage response (DDR) orchestrates DNA damage checkpoint activation and ...
Björn Schumacher, Rania Nakad
doaj +1 more source
Activation of DNA Damage Response Signaling by Condensed Chromatin
Cell Reports, 2014 Summary: The DNA damage response (DDR) occurs in the context of chromatin, and architectural features of chromatin have been implicated in DNA damage signaling and repair. Whereas a role of chromatin decondensation in the DDR is well established, we show
Rebecca C. Burgess +3 more
doaj +1 more source
Imaging the Response to DNA Damage in Heterochromatin Domains
Frontiers in Cell and Developmental Biology, 2022 The eukaryotic genome is assembled in a nucleoprotein complex called chromatin, whose organization markedly influences the repair of DNA lesions. For instance, compact chromatin states, broadly categorized as heterochromatin, present a challenging ...
Audrey Chansard +3 more
doaj +1 more source
The Role of Malfunctioning DNA Damage Response (DDR) in Brain Degeneration
Opera Medica et Physiologica, 2016 Maintenance of genome stability in the face of DNA damage is essential for cellular homeostasis and prevention of cancer and brain degeneration. The DNA damage response (DDR) is a complex response that is rapidly activated when a DNA lesion occurs in chromosomal DNA.
TALYA SHACHAM +4 more
openaire +2 more sources
DNA damage response (DDR) via NKX3.1 expression in prostate cells
The Journal of Steroid Biochemistry and Molecular Biology, 2014 It has been reported that NKX3.1 an androgen-regulated homeobox gene restricted to prostate and testicular tissues, encodes a homeobox protein, which transcriptionally regulates oxidative damage responses and enhances topoisomerase I re-ligation by a direct interaction with the ATM protein in prostate cells.
Burcu Erbaykent-Tepedelen +3 more
openaire +4 more sources
Cellular Physiology and Biochemistry, 2018 Background/Aims: Alternative splicing and DNA damage exhibit cross-regulation, with not only DNA damage inducing changes in alternative splicing, but alternative splicing itself possibly modulating the DNA damage response (DDR).
Guangming Wang +10 more
doaj +1 more source
Antioxidants, 2021 AKI, due to the fact of altered oxygen supply after kidney transplantation, is characterized by renal ischemia–reperfusion injury (IRI). Recent data suggest that AKI to CKD progression may be driven by cellular senescence evolving from prolonged DNA ...
Floris A. Valentijn +12 more
doaj +1 more source
Regulation of the DNA Damage Response by Ubiquitin Conjugation
Frontiers in Genetics, 2015 In response to DNA damage, cells activate a highly conserved and complex kinase-based signaling network, commonly referred to as the DNA damage response (DDR), to safeguard genomic integrity.
Kerstin eBrinkmann +7 more
doaj +1 more source
Aging and Cancer, 2022 DNA molecules are subject to various lesions that can be detrimental to the cells. DNA damage response (DDR) pathways encompass a variety of mechanisms that cells employ in response to DNA damage.
Tianen Chen +11 more
doaj +1 more source