Results 81 to 90 of about 106,021 (225)

Cigarette Smoke‐Induced Alveolar Macrophage Senescence via GEM/SIRT3‐Mediated Mitochondrial Dysfunction

Advanced Science, EarlyView.
Cigarette smoke accelerates the aging of immune cells in the lung. By combining human single‐cell sequencing, cell culture, and mouse models, the authors show that the protein GEM drives mitochondrial damage and senescence in alveolar macrophages by suppressing SIRT3.
Jin Wang, Meidan Wei, Xiangrong Song, Jiaxin Zhang, Lisha Zhang, Sixian Chen, Yaoyu Hu, Hui Gao, Jianxiang Li   +8 more
wiley   +1 more source

Understanding DNA Damage Response and DNA Repair in Multiple Myeloma

Cancers, 2023
Simple Summary Multiple myeloma (MM), a malignant plasma cell disorder, is characterized by abnormal DNA damage response (DDR). MM cells adapt over time via gene mutations or chromosomal aberrations, including changes to DDR and DNA repair genes ...
Cole Petrilla, Joshua Galloway, Ruchi Kudalkar, Aya Ismael, F. Cottini   +4 more
semanticscholar   +1 more source

Genotoxin-producing Salmonella enterica induces tissue-specific types of DNA damage and DNA damage response outcomes

Frontiers in Immunology
IntroductionTyphoid toxin-expressing Salmonella enterica causes DNA damage in the intestinal mucosa in vivo, activating the DNA damage response (DDR) in the absence of inflammation.
Maria Lopez Chiloeches, Anna Bergonzini, Océane C. B. Martin, Nicole Bergstein, Saskia F. Erttmann, Saskia F. Erttmann, Kyaw Min Aung, Nelson O. Gekara, Nelson O. Gekara, Javier F. Avila Cariño, Ioannis S. Pateras, Teresa Frisan   +11 more
doaj   +1 more source

The RNA Processing Factor Y14 Participates in DNA Damage Response and Repair

iScience, 2019
Summary: DNA repair deficiency leads to genome instability and hence human disease. Depletion of the RNA processing factor Y14/RBM8A in cultured cells or Rbm8a haplodeficiency in the developing mouse cortex results in the accumulation of DNA damage.
Tzu-Wei Chuang, Chia-Chen Lu, Chun-Hao Su, Pei-Yu Wu, Sarasvathi Easwvaran, Chi-Chieh Lee, Hung-Che Kuo, Kuan-Yang Hung, Kuo-Ming Lee, Ching-Yen Tsai, Woan-Yuh Tarn   +10 more
doaj   +1 more source

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

DNA Damage Response Alterations in Ovarian Cancer: From Molecular Mechanisms to Therapeutic Opportunities

Cancers, 2023
Simple Summary The DNA damage response (DDR) is frequently altered in ovarian cancer (OC), which can be exploited for therapeutic purposes. Moreover, targeting DDR signaling pathways has become an attractive strategy for increasing the effect of DNA ...
M. Ovejero-Sánchez, R. González-Sarmiento, A. Herrero   +2 more
semanticscholar   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

NKX3.1 contributes to S phase entry and regulates DNA damage response (DDR) in prostate cancer cell lines [PDF]

Biochemical and Biophysical Research Communications, 2011
NKX3.1 is an androgen-regulated homeobox gene that encodes a tissue-restricted transcription factor, which plays an important role in the differentiation of the prostate epithelium. Thus, the role of NKX3.1 as a functional topoisomerase I activity enhancer in cell cycle regulation and the DNA damage response (DDR) was explored in prostate cancer cell ...
Erbaykent-Tepedelen, Burcu, Ozmen, Besra, Varisli, Lokman, Gonen-Korkmaz, Ceren, Debelec-Butuner, Bilge, Syed, Hamid Muhammed, Yilmazer-Cakmak, Ozgur, Korkmaz, Kemal Sami   +7 more
openaire   +5 more sources

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

Monitoring the Activation of the DNA Damage Response Pathway in a 3D Spheroid Model. [PDF]

PLoS ONE, 2015
Monitoring the DNA-Damage Response (DDR) activated pathway in multicellular tumor spheroid models is an important challenge as these 3D models have demonstrated their major relevance in pharmacological evaluation.
Odile Mondesert, Céline Frongia, Olivia Clayton, Marie-Laure Boizeau, Valérie Lobjois, Bernard Ducommun   +5 more
doaj   +1 more source