Results 51 to 60 of about 1,213,538 (303)

Deciphering the DNA Damage Response [PDF]

Cell, 2015
This year's Albert Lasker Basic Medical Research Award honors Evelyn Witkin and Stephen J. Elledge, two pioneers in elucidating the DNA damage response, whose contributions span more than 40 years.
openaire   +2 more sources

TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy [PDF]

, 2013
Base damage and topoisomerase I (Top1)-linked DNA breaks are abundant forms of endogenous DNA breakage, contributing to hereditary ataxia and underlying the cytotoxicity of a wide range of anti-cancer agents.
Alagoz, Boyd, Breslin, Caldecott, Chen, Chiang, Ciccia, Dalhus, Das, Demple, Dungey, El-Khamisy, Fu, Godon, Hecht, Hegde, Hudson, Interthal, Interthal, Kato, Katyal, Kummar, Lebedeva, Lindahl, Lindahl, Liu, Loeb, Luo, Madhusudan, Meisenberg, Meryem Alagoz, Mohammed, Morland, Murai, Murai, Nilsen, Owen S. Wells, Pommier, Pourquier, Povirk, Ray Chaudhuri, Rydberg, Sherif F. El-Khamisy, Strom, Sultana, Takashima, Wilson, Xanthoudakis, Yang, Zeng, Zhou   +50 more
core   +1 more source

Cellular Responses to DNA Damage

Annual Review of Pharmacology and Toxicology, 2001
Cells are constantly under threat from the cytotoxic and mutagenic effects of DNA damaging agents. These agents can either be exogenous or formed within cells. Environmental DNA-damaging agents include UV light and ionizing radiation, as well as a variety of chemicals encountered in foodstuffs, or as air- and water-borne agents.
Norbury, C, Hickson, I
openaire   +3 more sources

Exploring the links between cancer and placenta development [PDF]

Open Biology, 2018
The development of metastatic cancer is a multistage process, which often requires decades to complete. Impairments in DNA damage control and DNA repair in cancer cell precursors generate genetically heterogeneous cell populations.
Vincenzo Costanzo, Alberto Bardelli, Salvatore Siena, Sergio Abrignani   +3 more
doaj   +1 more source

TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1 [PDF]

, 2012
The abortive activity of topoisomerases can result in clastogenic and/or lethal DNA damage in which the topoisomerase is covalently linked to the 3'- or 5'-terminus of a DNA strand break. This type of DNA damage is implicated in chromosome translocations
Abhishek Sharma, Barthelmes, Danny Huylebroeck, Davies, Davies, El-Khamisy, El-Khamisy, El-Khamisy, El-Khamisy, Esguerra, Giovanella, Hirano, Hudson, Interthal, Interthal, Junko Murai, Katyal, Keith W. Caldecott, Ledesma, Liesbeth Vermeire, Lieve Umans, Limei Ju, Murai, Nitiss, Pommier, Pommier, Pype, Sherif F. El-Khamisy, Shunichi Takeda, Takashima, Varady, Vilotti, Yang, Yves Pommier, Zeng, Zhihong Zeng, Zhou   +36 more
core   +1 more source

γ-H2AX foci as in vivo effect biomarker in children emphasize the importance to minimize x-ray doses in paediatric CT imaging [PDF]

, 2014
Objectives: Investigation of DNA damage induced by CT x-rays in paediatric patients versus patient dose in a multicentre setting. Methods: From 51 paediatric patients (median age, 3.8 years) who underwent an abdomen or chest CT examination in one of the
A. De Backer, C. Ernst, C. Franck, C. Vandevoorde, H. Thierens, K. Bacher, K. Van De Moortele, L. Breysem, M. H. Smet, P. Smeets   +9 more
core   +2 more sources

Cellular Responses to DNA Damage

Environmental Health Perspectives, 1985
For many years, the study of the regulation of the SOS network was complicated by both the complexities of the responses and the interrelationships of the key regulatory elements. However, recently the application of powerful genetic and molecular biological techniques has allowed us to gain a detailed picture of the regulation of this complex network.
G C, Walker, L, Marsh, L, Dodson
openaire   +2 more sources

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex

EMBO Reports
Cyclosporin A (CsA) induces DNA double-strand breaks in LIG4 syndrome fibroblasts, specifically upon transit through S-phase. The basis underlying this has not been described.
Marisa Bedir, Emily Outwin, Rita Colnaghi, Lydia Bassett, Iga Abramowicz, Mark O’Driscoll   +5 more
doaj   +1 more source

Histone post-translational modification and the DNA damage response

Genes and Diseases, 2023
DNA is highly vulnerable to spontaneous and environmental timely damage in living cells. DNA damage may cause genetic instability and increase cancer risk if the damages are not repaired timely and efficiently.
Haoyun Song, Rong Shen, Xiangwen Liu, Xuguang Yang, Kun Xie, Zhao Guo, Degui Wang   +6 more
doaj   +1 more source

Modulation of gene expression in endothelial cells in response to high LET nickel ion irradiation [PDF]

, 2014
Ionizing radiation can elicit harmful effects on the cardiovascular system at high doses. Endothelial cells are critical targets in radiation-induced cardiovascular damage.
Aerts, An, Baatout, Sarah, Beck, Michaël, De Vos, Winnok, Dieriks, Birger, Ernst, Eric, Janssen, Ann, Lambert, Charles, Lee, Ryonfa, Michaux, Arlette, Moreels, Marjan, Neefs, Mieke, Quintens, Roel, Rombouts, Charlotte, Tabury, Kevin, Van Oostveldt, Patric   +15 more
core   +1 more source