Results 61 to 70 of about 7,503,880 (242)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Epigenome Maintenance in Response to DNA Damage [PDF]

Molecular Cell, 2016
Organism viability relies on the stable maintenance of specific chromatin landscapes, established during development, that shape cell functions and identities by driving distinct gene expression programs. Yet epigenome maintenance is challenged during transcription, replication, and repair of DNA damage, all of which elicit dynamic changes in chromatin
Juliette Dabin, Anna Fortuny, Sophie E. Polo   +2 more
openaire   +2 more sources

Quantification of complex DNA damage by ionising radiation: An experimental and theoretical approach [PDF]

, 2000
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Ionising radiation potentially produces a broad spectrum of damage in DNA including single and double strand breaks (ssb and dsb) and base damages.
Fulford, Jonathan
core   +7 more sources

O-GlcNAcylation at S659 enhances SARS-CoV-2 spike protein stability and pseudoparticle packaging efficiency

Microbiology Spectrum
The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) plays a crucial role in viral entry and pathogenesis, making it an important target for therapeutic strategies.
Ting Xu, Jie Li, Xiaoxuan Lu, Shuai Song, Shengnan Wang, Jing Li, Leiliang Zhang   +6 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Radiation-induced DNA damage responses [PDF]

Radiation Protection Dosimetry, 2006
The amazing feature of ionising radiation (IR) as a DNA damaging agent is the range of lesions it induces. Such lesions include base damage, single strand breaks (SSBs), double strand breaks (DSBs) of varying complexity and DNA cross links. A range of DNA damage response mechanisms operate to help maintain genomic stability in the face of such damage ...
Jeggo, Penny, Löbrich, Markus
openaire   +2 more sources

Anti-cancer immune responses to DNA damage response inhibitors: Molecular mechanisms and progress toward clinical translation

Frontiers in Oncology, 2022
DNA damage response inhibitors are widely used anti-cancer agents that have potent activity against tumor cells with deficiencies in various DNA damage response proteins such as BRCA1/2. Inhibition of other proteins in this pathway including PARP, DNA-PK,
Lindsey Carlsen, Lindsey Carlsen, Lindsey Carlsen, Lindsey Carlsen, Lindsey Carlsen, Wafik S. El-Deiry, Wafik S. El-Deiry, Wafik S. El-Deiry, Wafik S. El-Deiry, Wafik S. El-Deiry, Wafik S. El-Deiry   +10 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

SUMO in the DNA damage response

Oncotarget, 2015
Post-translational modification by Small Ubiquitin-like Modifiers (SUMOs) is critical for all eukaryotic life [1]. SUMO, like ubiquitin, is conjugated to lysine residues in target proteins through an enzymatic cascade involving E1, E2 and E3 enzymes, and SUMOylation of proteins can be reversed through the action of SUMO-specific proteases.
Hendriks, I.A., Vertegaal, A.C.O.
openaire   +3 more sources

O-GlcNAcylation of YTHDF2 antagonizes ERK-dependent phosphorylation and inhibits lung carcinoma

Fundamental Research
The intracellular O-linked N-acetylglucosamine (O-GlcNAc) glycosylation mediates many signal transduction events and regulates tumorigenesis. Previously the RNA N6-methyladenosine (m6A) reader, YTH (YT521-B homology) domain 2 (YTHDF2), has been shown to ...
Jie Li, Wen Zhou, Jianzhi Zhang, Li Ma, Zhuan Lv, Yiqun Geng, Xing Chen, Jing Li   +7 more
doaj   +1 more source