Results 81 to 90 of about 752,369 (314)

O‐glycosylation in viruses: A sweet tango

mLife
O‐glycosylation is an ancient yet underappreciated protein posttranslational modification, on which many bacteria and viruses heavily rely to perform critical biological functions involved in numerous infectious diseases or even cancer.
Annan Ming, Jianxin Zhao, Yihan Liu, Yibo Wang, Xiaohui Wang, Jing Li, Leiliang Zhang   +6 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Drosophila RecQ4 Is Directly Involved in Both DNA Replication and the Response to UV Damage in S2 Cells.

, 2012
The RecQ4 protein shows homology to both the S.cerevisiae DNA replication protein Sld2 and the DNA repair related RecQ helicases. Experimental data also suggest replication and repair functions for RecQ4, but the precise details of its involvement remain
Miyata Seiji, Isabelle Crevel, Seiji Miyata, Vo, N, Gilles Crevel (33987), Vo Nicole, Cotterill, S, Isabelle Crevel (119003), Miyata, S, Sue Cotterill (33993), Hoa, L, Lily Hoa (119009), Crevel Isabelle, Hamid Sana, Nicole Vo (119001), Hoa Lily, Cotterill Sue, Sana Hamid, Crevel Gilles, Crevel, G, Crevel, I, Lily Hoa, Nicole Vo, Gilles Crevel, Sana Hamid (119006), Hamid, S, Sue Cotterill, Seiji Miyata (119012)   +27 more
core   +1 more source

Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase [PDF]

, 2014
Upon DNA damage, cell cycle progression is temporally blocked to avoid propagation of mutations. While transformed cells largely maintain the competence to recover from a cell cycle arrest, untransformed cells past the G1/S transition lose mitotic ...
Jaiswal, H., Mullers, E, Cascales, H.S., Cascales, HS, Lindqvist, A., Jaiswal, H, Saurin, AT, Lindqvist, A,, Müllers, E., Saurin, A.T.; id_orcid   +9 more
core   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Human checkpoint proteins hRad9, hHus1, and hRad1 form a DNA damage-responsive complex [PDF]

, 2004
Human cells have evolved protective mechanisms such as DNA repair and cell cycle checkpoints in order to promote stability of the genome. Studies on hereditary instability syndromes associated with a higher incidence of malignancies like Xeroderma ...
Volkmer, Elias
core  

Chromatin Modifications Involved in the DNA Damage Response to Double Strand Breaks

, 2009
In eukaryotes, genomic DNA is tightly compacted into a protein-DNA complex known as chromatin. This dense structure presents a barrier to DNA-dependent processes including transcription, replication and DNA repair.
Jones, Mathew J. K., Khanna, Kum Kum, Pagan, Julia K., Jones, Mathew, Emma Bolderson, Mathew Jones, Pagan, Julia, Bolderson, Emma, Kum Kum Khanna, Julia Pagan   +9 more
core   +1 more source

DNA damage response inhibition‐based combination therapies in cancer treatment: Recent advances and future directions

Aging and Cancer, 2022
DNA molecules are subject to various lesions that can be detrimental to the cells. DNA damage response (DDR) pathways encompass a variety of mechanisms that cells employ in response to DNA damage.
Tianen Chen, Suparat Tongpeng, Ziyi Lu, Win Topatana, Sarun Juengpanich, Shijie Li, Jiahao Hu, Jiasheng Cao, Cheeshin Lee, Yitong Tian, Mingyu Chen, Xiujun Cai   +11 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Analysis of telomere length and function in radiosensitive mouse and human cells in response to DNA-PKcs inhibition [PDF]

, 2013
© 2013 Yasaei et al.; licensee BioMed Central Ltd.This article has been made available through the Brunel Open Access Publishing Fund.Telomeres, the physical ends of chromosomes, play an important role in preserving genomic integrity.
Slijepcevic, P, Yaghoub Gozaly-Chianea, Yasaei, H, Predrag Slijepcevic, Hemad Yasaei, Gozaly-Chianea, Y   +5 more
core   +1 more source