Results 81 to 90 of about 1,213,538 (303)

Wild-type p53-induced phosphatase 1 down-regulation promotes apoptosis by activating the DNA damage-response pathway in amyotrophic lateral sclerosis

Neurobiology of Disease, 2020
Accumulation of DNA damage has been detected in the spinal cord of patients as well as in the G93A mouse model of amyotrophic lateral sclerosis (ALS).
Yue-Qing Yang, Yong-Hui Zheng, Chun-Ting Zhang, Wei-Wei Liang, Shu-Yu Wang, Xu-Dong Wang, Ying Wang, Tian-Hang Wang, Hong-Quan Jiang, Hong-Lin Feng   +9 more
doaj   +1 more source

DNA damage response and hematological malignancy [PDF]

International Journal of Hematology, 2017
DNA damage is a serious threat to cellular homeostasis. Damaged DNA leads to genomic instability, mutation, senescence, and/or cell death. DNA damage triggers a cellular response called the DNA damage response (DDR), followed by activation of the DNA repair machinery. DDR both maintains cellular homeostasis and prevents cancer development.
openaire   +3 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

DNA damage-induced YTHDC1 O-GlcNAcylation promotes homologous recombination by enhancing m6A binding

Fundamental Research
N6-methyladenosine (m6A) is the most prevalent internal RNA modification, and its regulators include writers, readers and erasers. m6A is under stringent control and takes part in many biological events, but it is not known whether there is an interplay ...
Mengyao Li, Jie Li, Yibo Wang, Jianxin Zhao, Aiyun Yuan, Weidong Dong, Linlin Kong, Suwei Dong, Weijie Qin, Yun-Gui Yang, Xiaohui Wang, Chen Wu, Jing Li   +12 more
doaj   +1 more source

PHF2 regulates homology-directed DNA repair by controlling the resection of DNA double strand breaks [PDF]

, 2020
Post-translational histone modifications and chromatin remodelling play a critical role controlling the integrity of the genome. Here, we identify histone lysine demethylase PHF2 as a novel regulator of the DNA damage response by regulating DNA damage ...
Alonso de la Vega, Ignacio, Attikum, Haico van, Checa Rodríguez, Cintia, Freire, Raimundo, Hernández Fernaud, Juan Ramón, Huertas, Pablo, Paz Cabrera, María Cristina, Rother, Magdalena B, Smits, Veronique A J, Wiegant, Wouter W   +9 more
core   +1 more source

PARPs and the DNA damage response [PDF]

Carcinogenesis, 2012
Adenosine diphosphate (ADP)-ribosylation is an important posttranslational modification catalyzed by a variety of enzymes, including poly (ADP ribose) polymerases (PARPs), which use nicotinamide adenine dinucleotide (NAD(+)) as a substrate to synthesize and transfer ADP-ribose units to acceptor proteins.
Fabricio G, Sousa, Renata, Matuo, Daniele G, Soares, Alexandre E, Escargueil, João A P, Henriques, Annette K, Larsen, Jenifer, Saffi   +6 more
openaire   +2 more sources

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage [PDF]

, 2016
Cellular responses to DNA damage require the formation of protein complexes in a highly organized fashion. The complete molecular components that participate in the sequential signaling response to DNA damage remain unknown.
Lazo, Pedro A., Monsalve, Diana M., Sanz-García, Marta, Sevilla Hernández, Ana   +3 more
core   +1 more source

ATM Activation and DNA Damage Response [PDF]

Cell Cycle, 2007
Well before the gene (ATM) mutated in the human genetic disorder ataxia-telangiectasia (A-T) was described it was evident from the clinical, molecular and cellular phenotype of A-T that this gene would play a central role in the DNA damage response. Mutation of ATM causes defective cell cycle checkpoint activation,a reduced capacity for repair of DNA ...
Lavin, MF, Kozlov, S
openaire   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source