Results 91 to 100 of about 752,369 (314)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

CHROMATIN STRUCTURE AND DNA DAMAGE RESPONSE

Паёми Сино, 2017
Genomic integrity is constantly exposed to the products of metabolic activities and environmental processes that can induce DNA damage. A well-organized network of signaling cascade, designated as DNA damage response (DDR), encompasses systems of damage ...
M.A. NORMATOVA
doaj   +1 more source

The Interplay Between the DNA Damage Response, RNA Processing and Extracellular Vesicles

Frontiers in Oncology, 2020
RNA processing was recently found to affect DNA damage response. The RNA processing factors THRAP3 and BCLAF1 play critical role in keeping DNA genomic stability by regulating the transcription, mRNA splicing and export of DNA repair proteins BRCA2 ...
Xiangbing Meng, Xiangbing Meng, Shujie Yang, Shujie Yang, Vanessa J. A. Camp   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

DNA damage response and hematological malignancy [PDF]

International Journal of Hematology, 2017
DNA damage is a serious threat to cellular homeostasis. Damaged DNA leads to genomic instability, mutation, senescence, and/or cell death. DNA damage triggers a cellular response called the DNA damage response (DDR), followed by activation of the DNA repair machinery. DDR both maintains cellular homeostasis and prevents cancer development.
openaire   +3 more sources

Simultaneous Disruption of Two DNA Polymerases, Pol eta and Pol zeta, in Avian DT40 Cells Unmasks the Role of Pol eta in Cellular Response to Various DNA Lesions [PDF]

, 2010
Replicative DNA polymerases are frequently stalled by DNA lesions. The resulting replication blockage is released by homologous recombination (HR) and translesion DNA synthesis (TLS). TLS employs specialized TLS polymerases to bypass DNA lesions.
Sonoda, E, Dávid Szüts, Hirota Kouji, Takuo Kawamoto, Shunichi Takeda, Motegi, Akira, Motegi Akira, Fumio Hanaoka, Kawamoto Takuo, Julian E. Sale, Kawamoto, Takuo, Iwai, Shigenori, Julian E Sale, Sale Julian E., Sonoda Eiichiro, Masutani Chikahide, Shigenori Iwai, Alan Lehmann, Masutani, C, Takeda, Shunichi, Iwai Shigenori, Lehmann, Alan, Chikahide Masutani, Szüts, Dávid, Iwai, S, Eiichiro Sonoda, Motegi, A, Kawamoto, T, Masutani, Chikahide, Kouji Hirota, Hanaoka Fumio, Szüts, D, Takeda Shunichi, Hirota, Kouji, Sale, Julian E, Szüts Dávid, Hanaoka, Fumio, Lehmann Alan, Takeda, S, Hirota, K, Hanaoka, F, Sale, JE, Akira Motegi, Sonoda, Eiichiro, Lehmann, A   +44 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Molecular mechanisms of ARF regulation in response to DNA damage

, 2014
DNA is a highly unstable molecule. Endogenous souces of DNA damage, such as reactive oxygen species (ROS), can cause DNA damage and it has been estimated that 20000 lesions occur in a cell per day. BER is the major pathway for the repair of these lesions
Orlando, Giulia
core   +1 more source

Interplay of space radiation and microgravity in DNA damage and DNA damage response

npj Microgravity, 2017
In space, multiple unique environmental factors, particularly microgravity and space radiation, pose constant threat to the DNA integrity of living organisms.
María Moreno-Villanueva, Michael Wong, Tao Lu, Ye Zhang, Honglu Wu   +4 more
doaj   +1 more source

The Histone-Fold Protein CHRAC14 Influences Chromatin Composition in Response to DNA Damage

Cell Reports, 2014
Summary: Chromatin reorganization and the incorporation of specific histone modifications during DNA damage response are essential steps for the successful repair of any DNA lesion.
Veena Mathew, Anne-Laure Pauleau, Natascha Steffen, Andrea Bergner, Peter B. Becker, Sylvia Erhardt   +5 more
doaj   +1 more source