Results 41 to 50 of about 7,503,880 (242)
RTEL1 Inhibits Trinucleotide Repeat Expansions and Fragility
Cell Reports, 2014 Human RTEL1 is an essential, multifunctional helicase that maintains telomeres, regulates homologous recombination, and helps prevent bone marrow failure.
Aisling Frizzell +6 more
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Bacterial Genotoxin-Induced DNA Damage and Modulation of the Host Immune Microenvironment
Toxins, 2020 Bacterial genotoxins (BTGX) induce DNA damage, which results in senescence or apoptosis of the target cells if not properly repaired. Three BTGXs have been identified: the cytolethal distending toxin (CDT) family produced by several Gram-negative ...
Océane C.B. Martin, Teresa Frisan
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Cellular Responses to DNA Damage
Annual Review of Pharmacology and Toxicology, 2001 Cells are constantly under threat from the cytotoxic and mutagenic effects of DNA damaging agents. These agents can either be exogenous or formed within cells. Environmental DNA-damaging agents include UV light and ionizing radiation, as well as a variety of chemicals encountered in foodstuffs, or as air- and water-borne agents.
Norbury, C, Hickson, I
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Scorpins in the DNA Damage Response [PDF]
International Journal of Molecular Sciences, 2018 The DNA Damage Response (DDR) is a complex signaling network that comes into play when cells experience genotoxic stress. Upon DNA damage, cellular signaling pathways are rewired to slow down cell cycle progression and allow recovery. However, when the damage is beyond repair, cells activate complex and still not fully understood mechanisms, leading to
Dario Palmieri +2 more
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OCT4A and the DNA damage response [PDF]
Cell Cycle, 2015 OCT4A is best known as a “master” transcription factor involved in stem cell pluripotency and self renewal in concert with SOX2 and NANOG. Although there has been some indication of a dialog between OCT4 and elements of DNA repair,1 a recent article published in Cell Cycle by Huna and colleagues2 establishes OCT4A as a multifunctional protein with a ...
Murray, David, Mirzayans, Razmik
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Exploring the links between cancer and placenta development [PDF]
Open Biology, 2018 The development of metastatic cancer is a multistage process, which often requires decades to complete. Impairments in DNA damage control and DNA repair in cancer cell precursors generate genetically heterogeneous cell populations.
Vincenzo Costanzo +3 more
doaj +1 more source
The RNA Response to DNA Damage [PDF]
Journal of Molecular Biology, 2016 Multicellular organisms must ensure genome integrity to prevent accumulation of mutations, cell death, and cancer. The DNA damage response (DDR) is a complex network that senses, signals, and executes multiple programs including DNA repair, cell cycle arrest, senescence, and apoptosis.
Giono, Luciana E. +5 more
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DNA damage responses in the context of the cell division cycle [PDF]
, 2010 During my PhD, I have investigated aspects of the DNA damage response (DDR) in the context of three different cellular scenarios: DNA damage signalling in response to double-strand breaks during mitosis, coordination of DNA replication with DNA damage ...
core +2 more sources
Ribonucleotide triggered DNA damage and RNA-DNA damage responses [PDF]
RNA Biology, 2014 Research indicates that the transient contamination of DNA with ribonucleotides exceeds all other known types of DNA damage combined. The consequences of ribose incorporation into DNA, and the identity of protein factors operating in this RNA-DNA realm to protect genomic integrity from RNA-triggered events are emerging. Left unrepaired, the presence of
Bret D, Wallace, R Scott, Williams
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EMBO ReportsCyclosporin A (CsA) induces DNA double-strand breaks in LIG4 syndrome fibroblasts, specifically upon transit through S-phase. The basis underlying this has not been described.
Marisa Bedir +5 more
doaj +1 more source