Results 21 to 30 of about 1,213,538 (303)

PLK1-mediated phosphorylation of PPIL2 regulates HR via CtIP

Frontiers in Cell and Developmental Biology, 2022
Homologous recombination (HR) is an error-free DNA double-strand break (DSB) repair pathway, which safeguards genome integrity and cell viability. Human C-terminal binding protein (CtBP)—interacting protein (CtIP) is a central regulator of the pathway ...
Zhiyu Qiu, Shuailin Hao, Shikai Song, Ruiling Zhang, Tingyu Yan, Zhifang Lu, Hailong Wang, Zongchao Jia, Jimin Zheng   +8 more
doaj   +1 more source

DNA damage induced during mitosis undergoes DNA repair synthesis. [PDF]

, 2020
Understanding the mitotic DNA damage response (DDR) is critical to our comprehension of cancer, premature aging and developmental disorders which are marked by DNA repair deficiencies.
Berns, Michael W, Cohen, Shirli, Gomez Godinez, Veronica, Kabbara, Sami, Kong, Xiangduo, Maravillas-Montero, Jose Luis, Preece, Daryl, Sherman, Adria, Shi, Zhixia, Wu, Tao, Yokomori, Kyoko   +10 more
core   +1 more source

DNA Damage Tolerance Pathways in Human Cells: A Potential Therapeutic Target

Frontiers in Oncology, 2022
DNA lesions arising from both exogenous and endogenous sources occur frequently in DNA. During DNA replication, the presence of unrepaired DNA damage in the template can arrest replication fork progression, leading to fork collapse, double-strand break ...
Ashlynn Ai Li Ler, Michael P. Carty, Michael P. Carty   +2 more
doaj   +1 more source

Ribonucleotide triggered DNA damage and RNA-DNA damage responses [PDF]

RNA Biology, 2014
Research indicates that the transient contamination of DNA with ribonucleotides exceeds all other known types of DNA damage combined. The consequences of ribose incorporation into DNA, and the identity of protein factors operating in this RNA-DNA realm to protect genomic integrity from RNA-triggered events are emerging. Left unrepaired, the presence of
Bret D, Wallace, R Scott, Williams
openaire   +2 more sources

miRNA response to DNA damage [PDF]

Trends in Biochemical Sciences, 2011
Faithful transmission of genetic material in eukaryotic cells requires not only accurate DNA replication and chromosome distribution but also the ability to sense and repair spontaneous and induced DNA damage. To maintain genomic integrity, cells undergo a DNA damage response using a complex network of signaling pathways composed of coordinate sensors,
Guohui, Wan, Rohit, Mathur, Xiaoxiao, Hu, Xinna, Zhang, Xiongbin, Lu   +4 more
openaire   +2 more sources

Amelioration of cadmium cytotoxicity to human cells by nutrient cation contents and the building of a biotic ligand model

Ecotoxicology and Environmental Safety, 2023
A variety of important major and trace elements may competitively inhibit cadmium (Cd) absorption in human cells and reduce Cd toxicity. However, the impact of essential elements on the cytotoxicity of metals can be difficult to quantify and anticipate ...
Yujie Tang, Hailong Wang, Qihao Wang, Xuedong Wang   +3 more
doaj   +1 more source

Inflammation-induced DNA damage and damage-induced inflammation: a vicious cycle [PDF]

, 2014
Inflammation is the ultimate response to the constant challenges of the immune system by microbes, irritants or injury. The inflammatory cascade initiates with the recognition of microorganism-derived pathogen associated molecular patterns (PAMPs) and ...
Abe, Alexeyev, Andersson, Andersson, Ba, Babior, Bartoloni, Berger, Blyth, Brill, Brinkmann, Cadet, Collins, Cooke, Csanád Z. Bachrati, David, Ding, Dostert, Ermakov, Ermakov, Ferguson, Fuchs, Gahan, Gedik, Gehrke, Hajizadeh, Halle, Hiramoto, Huang, Huang, Huang, Huttunen, Ishikawa, Ivana, Ivanov, Jahr, Jia, Kang, Kanneganti, Kazak, Klebanoff, Knaapen, Kondo, Kostyuk, Kostyuk, Krieg, Kuechle, Lane, Lange, Latz, Li, Malins, Mariathasan, Munoz-Gamez, Nakahira, Oka, Pacher, Parvatiyar, Pasheva, Pinti, Polk, Rathinam, Saitoh, Saxena, Scaffidi, Schroder, Shimada, Shokolenko, Sun, Suter, Suzuki, Swindall, Tadie, Taguchi, Takeda, Takeda, Tang, Tang, Thomson, Timea Pálmai-Pallag, Unterholzner, Urbonaviciute, Venereau, Volcic, Weinberg, Weiss, Wilson, Wu, Yan, Yang, Yoshida, Yoshihara, Yotsumoto, You, Yousefi, Zhang, Zhang, Zhang, Zhang, Zhang, Zhou   +100 more
core   +1 more source

DNA damage responses in ageing [PDF]

Open Biology, 2019
Ageing appears to be a nearly universal feature of life, ranging from unicellular microorganisms to humans. Longevity depends on the maintenance of cellular functionality, and an organism's ability to respond to stress has been linked to functional maintenance and longevity.
Paulo F. L. da Silva, Björn Schumacher
openaire   +3 more sources

DNA damage checkpoint and repair: From the budding yeast Saccharomyces cerevisiae to the pathogenic fungus Candida albicans

Computational and Structural Biotechnology Journal, 2021
Cells are constantly challenged by internal or external genotoxic assaults, which may induce a high frequency of DNA lesions, leading to genome instability.
Shuangyan Yao, Yuting Feng, Yan Zhang, Jinrong Feng   +3 more
doaj   +1 more source

DNA Damage and DNA Damage Response in Chronic Myeloid Leukemia [PDF]

International Journal of Molecular Sciences, 2020
DNA damage and alterations in the DNA damage response (DDR) are critical sources of genetic instability that might be involved in BCR-ABL1 kinase-mediated blastic transformation of chronic myeloid leukemia (CML). Here, increased DNA damage is detected by γH2AX foci analysis in peripheral blood mononuclear cells (PBMCs) of de novo untreated chronic ...
Henning D. Popp, Vanessa Kohl, Nicole Naumann, Johanna Flach, Susanne Brendel, Helga Kleiner, Christel Weiss, Wolfgang Seifarth, Susanne Saussele, Wolf-Karsten Hofmann, Alice Fabarius   +10 more
openaire   +2 more sources