Results 21 to 30 of about 716,098 (263)
Transcriptional responses to DNA damage [PDF]
DNA Repair, 2019 In response to the threat of DNA damage, cells exhibit a dramatic and multi-factorial response spanning from transcriptional changes to protein modifications, collectively known as the DNA damage response (DDR). Here, we review the literature surrounding the transcriptional response to DNA damage.
Erica, Silva, Trey, Ideker
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AsSIRTing the DNA damage response [PDF]
Trends in Cell Biology, 2008 In mammalian cells, changes in signaling networks and expressed proteins ensure the adequate detection and management of damaged macromolecules. Here, we review an emergent pathway of maintenance of homeostasis following genotoxic stress. The RNA-binding protein HuR associates with sirtuin (SIRT)1 mRNA and maintains constitutively elevated levels of ...
Myriam, Gorospe, Rafael, de Cabo
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DNA Damage and DNA Damage Response in Chronic Myeloid Leukemia [PDF]
International Journal of Molecular Sciences, 2020 DNA damage and alterations in the DNA damage response (DDR) are critical sources of genetic instability that might be involved in BCR-ABL1 kinase-mediated blastic transformation of chronic myeloid leukemia (CML). Here, increased DNA damage is detected by γH2AX foci analysis in peripheral blood mononuclear cells (PBMCs) of de novo untreated chronic ...
Henning D. Popp +10 more
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Autophagic Organelles in DNA Damage Response
Frontiers in Cell and Developmental Biology, 2021 Autophagy is an important subcellular event engaged in the maintenance of cellular homeostasis via the degradation of cargo proteins and malfunctioning organelles.
Jeongha Kim +7 more
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Bacterial Genotoxin-Induced DNA Damage and Modulation of the Host Immune Microenvironment
Toxins, 2020 Bacterial genotoxins (BTGX) induce DNA damage, which results in senescence or apoptosis of the target cells if not properly repaired. Three BTGXs have been identified: the cytolethal distending toxin (CDT) family produced by several Gram-negative ...
Océane C.B. Martin, Teresa Frisan
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The concerted roles of FANCM and Rad52 in the protection of common fragile sites
Nature Communications, 2018 Fanconi anemia core proteins have been linked to common fragile site stability. Here the authors shed light into the role of FANCM in common fragile site protection by suppressing double-strand break formation and mitotic recombination.
Hailong Wang +5 more
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RTEL1 Inhibits Trinucleotide Repeat Expansions and Fragility
Cell Reports, 2014 Human RTEL1 is an essential, multifunctional helicase that maintains telomeres, regulates homologous recombination, and helps prevent bone marrow failure.
Aisling Frizzell +6 more
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Deciphering the DNA Damage Response [PDF]
Cell, 2015 This year's Albert Lasker Basic Medical Research Award honors Evelyn Witkin and Stephen J. Elledge, two pioneers in elucidating the DNA damage response, whose contributions span more than 40 years.
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DNA damage responses in ageing [PDF]
Open Biology, 2019 Ageing appears to be a nearly universal feature of life, ranging from unicellular microorganisms to humans. Longevity depends on the maintenance of cellular functionality, and an organism's ability to respond to stress has been linked to functional maintenance and longevity.
Paulo F. L. da Silva, Björn Schumacher
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Scorpins in the DNA Damage Response [PDF]
International Journal of Molecular Sciences, 2018 The DNA Damage Response (DDR) is a complex signaling network that comes into play when cells experience genotoxic stress. Upon DNA damage, cellular signaling pathways are rewired to slow down cell cycle progression and allow recovery. However, when the damage is beyond repair, cells activate complex and still not fully understood mechanisms, leading to
Dario Palmieri +2 more
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