Results 21 to 30 of about 7,503,880 (242)
ULK1 in autophagy: sugar it up
Autophagy Reports, 2022 Autophagy is a highly conserved cellular degradation and recycling process in mammalian cells, which is comprised of three main types: microautophagy, macroautophagy, and chaperone-mediated autophagy (CMA).
Sheng Yan, Jing Li
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PARPs and the DNA damage response [PDF]
Carcinogenesis, 2012 Adenosine diphosphate (ADP)-ribosylation is an important posttranslational modification catalyzed by a variety of enzymes, including poly (ADP ribose) polymerases (PARPs), which use nicotinamide adenine dinucleotide (NAD(+)) as a substrate to synthesize and transfer ADP-ribose units to acceptor proteins.
Fabricio G, Sousa +6 more
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PLK1-mediated phosphorylation of PPIL2 regulates HR via CtIP
Frontiers in Cell and Developmental Biology, 2022 Homologous recombination (HR) is an error-free DNA double-strand break (DSB) repair pathway, which safeguards genome integrity and cell viability. Human C-terminal binding protein (CtBP)—interacting protein (CtIP) is a central regulator of the pathway ...
Zhiyu Qiu +8 more
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Transcriptional responses to DNA damage [PDF]
DNA Repair, 2019 In response to the threat of DNA damage, cells exhibit a dramatic and multi-factorial response spanning from transcriptional changes to protein modifications, collectively known as the DNA damage response (DDR). Here, we review the literature surrounding the transcriptional response to DNA damage.
Erica, Silva, Trey, Ideker
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AsSIRTing the DNA damage response [PDF]
Trends in Cell Biology, 2008 In mammalian cells, changes in signaling networks and expressed proteins ensure the adequate detection and management of damaged macromolecules. Here, we review an emergent pathway of maintenance of homeostasis following genotoxic stress. The RNA-binding protein HuR associates with sirtuin (SIRT)1 mRNA and maintains constitutively elevated levels of ...
Myriam, Gorospe, Rafael, de Cabo
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Sphingolipids in the DNA damage response [PDF]
Advances in Biological Regulation, 2015 Recently, sphingolipid metabolizing enzymes have emerged as important targets of many chemotherapeutics and DNA damaging agents and therefore play significant roles in mediating the physiological response of the cell to DNA damage. In this review we will highlight points of connection between the DNA damage response (DDR) and sphingolipid metabolism ...
Brittany, Carroll +2 more
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miRNA response to DNA damage [PDF]
Trends in Biochemical Sciences, 2011 Faithful transmission of genetic material in eukaryotic cells requires not only accurate DNA replication and chromosome distribution but also the ability to sense and repair spontaneous and induced DNA damage. To maintain genomic integrity, cells undergo a DNA damage response using a complex network of signaling pathways composed of coordinate sensors,
Guohui, Wan +4 more
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DNA Damage Tolerance Pathways in Human Cells: A Potential Therapeutic Target
Frontiers in Oncology, 2022 DNA lesions arising from both exogenous and endogenous sources occur frequently in DNA. During DNA replication, the presence of unrepaired DNA damage in the template can arrest replication fork progression, leading to fork collapse, double-strand break ...
Ashlynn Ai Li Ler +2 more
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Ecotoxicology and Environmental Safety, 2023 A variety of important major and trace elements may competitively inhibit cadmium (Cd) absorption in human cells and reduce Cd toxicity. However, the impact of essential elements on the cytotoxicity of metals can be difficult to quantify and anticipate ...
Yujie Tang +3 more
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Phosphorylation events surrounding the DNA damage response in "Saccharomyces cerevisiae" [PDF]
, 2007 Protein phosphorylation mediated by checkpoint kinases is crucial for the cellular response to DNA damage. The sensor kinases Mec1 and Tel1 initiate the checkpoint signaling cascade by directly activating the checkpoint effector kinase Rad53.
Schleker, Thomas Andreas
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