Results 61 to 70 of about 15,256 (194)

Inhibition of poly(ADP-ribose) polymerase interferes with Trypanosoma cruzi infection and proliferation of the parasite.

PLoS ONE, 2012
Poly(ADP-ribosylation) is a post-translational covalent modification of proteins catalyzed by a family of enzymes termed poly(ADP-ribose) polymerases (PARPs).
Salomé C Vilchez Larrea, Teemu Haikarainen, Mohit Narwal, Mariana Schlesinger, Harikanth Venkannagari, Mirtha M Flawiá, Silvia H Fernández Villamil, Lari Lehtiö   +7 more
doaj   +1 more source

To translate, or not to translate: viral and host mRNA regulation by interferon-stimulated genes. [PDF]

, 2015
Type I interferon (IFN) is one of the first lines of cellular defense against viral pathogens. As a result of IFN signaling, a wide array of IFN-stimulated gene (ISG) products is upregulated to target different stages of the viral life cycle.
Li, Melody MH, MacDonald, Margaret R, Rice, Charles M   +2 more
core   +1 more source

An assay to measure poly(ADP ribose) glycohydrolase (PARG) activity in cells [version 1; referees: 2 approved]

F1000Research, 2016
After a DNA damage signal multiple polymers of ADP ribose attached to poly(ADP) ribose (PAR) polymerases (PARPs) are broken down by the enzyme poly(ADP) ribose glycohydrolase (PARG).
Dominic I. James, Stephen Durant, Kay Eckersley, Emma Fairweather, Louise A. Griffiths, Nicola Hamilton, Paul Kelly, Mark O'Connor, Kerry Shea, Ian D. Waddell, Donald J. Ogilvie   +10 more
doaj   +1 more source

Nicotinamide Adenine Dinucleotide (NAD) Metabolism as a Relevant Target in Cancer

Cells, 2022
NAD+ is an important metabolite in cell homeostasis that acts as an essential cofactor in oxidation–reduction (redox) reactions in various energy production processes, such as the Krebs cycle, fatty acid oxidation, glycolysis and serine biosynthesis ...
Lola E. Navas, Amancio Carnero
doaj   +1 more source

Fine-tuning of Smad protein function by poly(ADP-ribose) polymerases and poly(ADP-ribose) glycohydrolase during transforming growth factor β signaling. [PDF]

PLoS ONE, 2014
Initiation, amplitude, duration and termination of transforming growth factor β (TGFβ) signaling via Smad proteins is regulated by post-translational modifications, including phosphorylation, ubiquitination and acetylation.
Markus Dahl, Varun Maturi, Peter Lönn, Panagiotis Papoutsoglou, Agata Zieba, Michael Vanlandewijck, Lars P van der Heide, Yukihide Watanabe, Ola Söderberg, Michael O Hottiger, Carl-Henrik Heldin, Aristidis Moustakas   +11 more
doaj   +1 more source

DNA strand break repair and neurodegeneration. [PDF]

, 2013
A number of DNA repair disorders are known to cause neurological problems. These disorders can be broadly characterised into early developmental, mid-to-late developmental or progressive.
Abraham, Ahel, Alano, Alderton, Alter, Barbi, Barlow, Barnes, Bayatti, Bendixen, Bohr, Bootsma, Breslin, Brown, Buck, Buis, Caldecott, Caldecott, Caldecott, Cantoni, Chappell, Clements, Cortes Ledesma, Date, de Boer, de Boer, de Klein, de Vries, Delaval, Derheimer, Donahue, Durocher, El-Khamisy, El-Khamisy, El-Khamisy, Eliasson, Fattah, Frank, Frank, Frappart, Gao, Gao, Gatz, Goodship, Griffith, Gruber, Gueven, Henning, Hoeijmakers, Hoeijmakers, Jackson, Jeggo, Jilani, Kathe, Katyal, Keith W. Caldecott, Koch, Kuzminov, Lakin, Lakshmipathy, LaMonica, Le Ber, Lee, Lee, Lee, Lehmann, Letinic, Li, Licht, Lieber, Lindahl, Ljungman, Ljungman, Loizou, Luo, Mallery, Mao, Matsuura, Mayne, McKinnon, McKinnon, Mellon, Mischo, Mitchell, Moreira, Moreira, Moreno-Herrero, Morris, Moynahan, Mu, Murai, Murai, Murga, Nakane, Nance, Nilsen, Nussenzweig, Ogi, Okano, Orii, Osterod, Ouyang, O’Driscoll, O’Driscoll, O’Driscoll, Paula-Barbosa, Paull, Puebla-Osorio, Resnick, Revet, Reynolds, Reynolds, Rouse, Sanai, Schumacher, Shechter, Shen, Shiloh, Shull, Sidman, Skourti-Stathaki, Sleeth, Sonoda, Stefanini, Stewart, Stiff, Stuart L. Rulten, Sugasawa, Syljuasen, Takashima, Taylor, Tebbs, Theunissen, Thorslund, Uziel, van der Burg, van der Horst, Varon, Verhagen, Vinters, Virag, Vrouwe, Waltes, Weeda, Weterings, Whitehouse, Williams, Williams, Xu, Yu, Yu, Yuce, Zecevic, Zecevic, Zhou, Zhou, Zhu, Zou   +157 more
core   +1 more source

The roles of poly(ADP-ribose)-metabolizing enzymes in alkylation-induced cell death [PDF]

, 2018
.: Poly(ADP-ribose) (PAR) has been identified as a DNA damage-inducible cell death signal upstream of apoptosis-inducing factor (AIF). PAR causes the translocation of AIF from mitochondria to the nucleus and triggers cell death.
Althaus, F., Blenn, C., Cohausz, O., Malanga, M.   +3 more
core  

Chromatin to Clinic: The Molecular Rationale for PARP1 Inhibitor Function. [PDF]

, 2015
Poly(ADP-ribose) polymerase 1 (PARP1) inhibitors were recently shown to have potential clinical impact in a number of disease settings, particularly as related to cancer therapy, treatment for cardiovascular dysfunction, and suppression of inflammation ...
de Bono, Johann S., Feng, Felix Y., Knudsen, Karen E, Rubin, Mark A.   +3 more
core   +2 more sources

NAD+ Metabolism as an Emerging Therapeutic Target for Cardiovascular Diseases Associated With Sudden Cardiac Death

Frontiers in Physiology, 2020
In addition to its central role in mediating oxidation reduction in fuel metabolism and bioenergetics, nicotinamide adenine dinucleotide (NAD+) has emerged as a vital co-substrate for a number of proteins involved in diverse cellular processes, including
Weiyi Xu, Le Li, Le Li, Lilei Zhang
doaj   +1 more source

PASTA: PARP activity screening and inhibitor testing assay

STAR Protocols, 2021
Summary: Small-molecule inhibitors have been instrumental in uncovering the biological importance of poly-ADP-ribose polymerases (PARPs), a family of enzymes involved in wide-ranging aspects of cell biology.
Ilsa T. Kirby, Daniel J. Sanderson, Michael S. Cohen   +2 more
doaj   +1 more source