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Poly(ADP‐ribose) polymerase is a zinc metalloenzyme [PDF]
European Journal of Biochemistry, 1984 Purified poly(ADP‐ribose) polymerase was inhibited by 1,10‐phenanthroline at pH <8. This inhibition and the inhibition by other chelating agents suggested that this enzyme was a metalloprotein. Atomic absorption spectroscopy showed the presence of one atom of zinc per protein molecule.
P, Zahradka, K, Ebisuzaki
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The sound of silence: RNAi in poly (ADP-Ribose) research [PDF]
, 2012 Poly(ADP-ribosyl)-ation is a nonprotein posttranslational modification of proteins and plays an integral part in cell physiology and pathology. The metabolism of poly(ADP-ribose) (PAR) is regulated by its synthesis by poly(ADP-ribose) polymerases (PARPs)
Wyrsch, P +5 more
core +1 more source
Nature Communications, 2018 Poly(ADP-ribose) polymerases (PARPs) catalyse ADP-ribose posttranslational modifications using NAD+ as a substrate. Here, the authors present the crystal structure of PARP-1 bound to the non-hydrolyzable NAD+ analog BAD and provide insights into the ...
Marie-France Langelier +4 more
doaj +1 more source
Metabolic roles of poly(ADP-ribose) polymerases [PDF]
Seminars in Cell & Developmental Biology, 2017 Poly(ADP-ribosyl)ation (PARylation) is an evolutionarily conserved reaction that had been associated with numerous cellular processes such as DNA repair, protein turnover, inflammatory regulation, aging or metabolic regulation. The metabolic regulatory tasks of poly(ADP-ribose) polymerases (PARPs) are complex, it is based on the regulation of metabolic
Vida, András +3 more
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VERO cells harbor a poly-ADP-ribose belt partnering their epithelial adhesion belt [PDF]
PeerJ, 2014 Poly-ADP-ribose (PAR) is a polymer of up to 400 ADP-ribose units synthesized by poly-ADP-ribose-polymerases (PARPs) and degraded by poly-ADP-ribose-glycohydrolase (PARG).
Laura Lafon-Hughes +3 more
doaj +2 more sources
, 2011 available in PMC 2012 November 09Poly(ADP-ribose) (pADPr) is a posttranslational modification that regulates protein function through two major mechanisms: covalent modification of acceptor proteins and noncovalent binding of proteins to pADPr.
Leung, Anthony +5 more
core +1 more source
Nature Communications, 2017 Tankyrase 1 and 2 are poly(ADP-ribose) polymerases that mark proteins for degradation, but there is a current lack of knowledge about their distinct functions and substrates.
Amit Bhardwaj +3 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2020 Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes that catalyze the addition of poly(ADP-ribose) (PAR) subunits onto themselves and other acceptor proteins.
Daniel Harrision +3 more
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The Viral Macrodomain Counters Host Antiviral ADP-Ribosylation
Viruses, 2020 Macrodomains, enzymes that remove ADP-ribose from proteins, are encoded by several families of RNA viruses and have recently been shown to counter innate immune responses to virus infection.
Yousef M. O. Alhammad, Anthony R. Fehr
doaj +1 more source
F1000Research, 2016 After a DNA damage signal multiple polymers of ADP ribose attached to poly(ADP) ribose (PAR) polymerases (PARPs) are broken down by the enzyme poly(ADP) ribose glycohydrolase (PARG).
Dominic I. James +10 more
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