Results 41 to 50 of about 15,256 (194)
Poly(ADP‐ribose) polymerase is a zinc metalloenzyme [PDF]
European Journal of Biochemistry, 1984 Purified poly(ADP‐ribose) polymerase was inhibited by 1,10‐phenanthroline at pH <8. This inhibition and the inhibition by other chelating agents suggested that this enzyme was a metalloprotein. Atomic absorption spectroscopy showed the presence of one atom of zinc per protein molecule.
P, Zahradka, K, Ebisuzaki
openaire +2 more sources
The Dichotomy of the Poly(ADP-Ribose) Polymerase-Like Thermozyme from Sulfolobus solfataricus
Challenges, 2018 The first evidence of an ADP-ribosylating activity in Archaea was obtained in Sulfolobus solfataricus(strain MT-4) where a poly(ADP-ribose) polymerase (PARP)-like thermoprotein, defined with the acronymous PARPSso, was found.
Maria Rosaria Faraone Mennella
doaj +1 more source
A polymorphism in the base excision repair gene PARP2 is associated with differential prognosis by chemotherapy among postmenopausal breast cancer patients. [PDF]
, 2015 BACKGROUND: Personalized therapy considering clinical and genetic patient characteristics will further improve breast cancer survival. Two widely used treatments, chemotherapy and radiotherapy, can induce oxidative DNA damage and, if not repaired, cell ...
Aittomäki, Kristiina +44 more
core +4 more sources
Nature Communications, 2018 Poly(ADP-ribose) polymerases (PARPs) catalyse ADP-ribose posttranslational modifications using NAD+ as a substrate. Here, the authors present the crystal structure of PARP-1 bound to the non-hydrolyzable NAD+ analog BAD and provide insights into the ...
Marie-France Langelier +4 more
doaj +1 more source
Role of poly(ADP-ribose) polymerases in male reproduction. [PDF]
Spermatogenesis, 2013 Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes involved in a wide variety of biological processes, including DNA repair and maintenance of genomic stability following genotoxic stress, and regulates the expression of various proteins at the transcriptional level as well as replication and differentiation.
Celik-Ozenci C, Tasatargil A.
europepmc +4 more sources
Methylation status of Dnmt1 promoter depends on poly(ADP-ribosy)lation [PDF]
, 2007 Research is focused on CpG islands and on the mechanism that poly(ADP-ribosyl)ation uses to defend the unmethylated state of these important DNA sequences which are located in the promoter regions of the housekeeping genes having a role of transcription ...
Zampieri, Michele
core +1 more source
Metabolic roles of poly(ADP-ribose) polymerases [PDF]
Seminars in Cell & Developmental Biology, 2017 Poly(ADP-ribosyl)ation (PARylation) is an evolutionarily conserved reaction that had been associated with numerous cellular processes such as DNA repair, protein turnover, inflammatory regulation, aging or metabolic regulation. The metabolic regulatory tasks of poly(ADP-ribose) polymerases (PARPs) are complex, it is based on the regulation of metabolic
Vida, András +3 more
openaire +3 more sources
VERO cells harbor a poly-ADP-ribose belt partnering their epithelial adhesion belt [PDF]
PeerJ, 2014 Poly-ADP-ribose (PAR) is a polymer of up to 400 ADP-ribose units synthesized by poly-ADP-ribose-polymerases (PARPs) and degraded by poly-ADP-ribose-glycohydrolase (PARG).
Laura Lafon-Hughes +3 more
doaj +2 more sources
Structure, function and inhibition of poly(ADP-ribose)polymerase, member 14 (PARP14) [PDF]
, 2018 Poly(ADP-ribose)polymerase, member 14 (PARP14, alternatively named ARTD8, BAL2, and COAST6) is an intracellular mono(ADP-ribosyl) transferase. PARP14 transfers a negatively charged ADP-ribose unit from a donor NAD+ molecule onto a target protein, post ...
Levonis, Stephan M +3 more
core +1 more source
Nature Communications, 2017 Tankyrase 1 and 2 are poly(ADP-ribose) polymerases that mark proteins for degradation, but there is a current lack of knowledge about their distinct functions and substrates.
Amit Bhardwaj +3 more
doaj +1 more source