Results 81 to 90 of about 15,256 (194)

New perspectives on the plant PARP family: Arabidopsis PARP3 is inactive, and PARP1 exhibits predominant poly (ADP-ribose) polymerase activity in response to DNA damage

BMC Plant Biology, 2019
Background Poly (ADP-ribosyl) ation (PARylation) is an important posttranslational modification that regulates DNA repair, gene transcription, stress responses and developmental processes in multicellular organisms.
Zongying Gu, Weiyang Pan, Wei Chen, Qichao Lian, Qiao Wu, Zeyu Lv, Xuan Cheng, Xiaochun Ge   +7 more
doaj   +1 more source

Functions of PARylation in DNA Damage Repair Pathways

Genomics, Proteomics & Bioinformatics, 2016
Protein poly ADP-ribosylation (PARylation) is a widespread post-translational modification at DNA lesions, which is catalyzed by poly(ADP-ribose) polymerases (PARPs).
Huiting Wei, Xiaochun Yu
doaj   +1 more source

Nutrition-Based Modulation of Poly-ADP-Ribosylation and its possible role in Alzheimer’s disease [PDF]

, 2015
Alzheimer’s Disease (AD) is the most common neurodegenerative disease and the main reason of dementia in the elderly. On the pathological point of view, it is characterized by extracellular aggregates of amyloid peptides and intracellular deposits of tau
Fuso, Andrea, Martire, Sara
core  

PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1α-mediated unfolded protein response [PDF]

, 2012
Poly(ADP-ribose) polymerases (PARPs; also known as ADP-ribosyl transferase D proteins) modify acceptor proteins with ADP-ribose modifications of varying length (reviewed in refs 1, 2, 3). PARPs regulate key stress response pathways, including DNA damage
A Bertolotti, AK Leung, BD Hamman, C Sidrauski, D Ron, E Pedrazzini, H Harding, H Kleine, H Lorenz, HP Harding, I Kim, J Ménissier-de Murcia, JD Malhotra, L Zheng, M Calfon, M Malanga, M Schuldiner, Miri Jwa, MO Hottiger, N Borgese, P Chang, P Walter, P Whitley, Paul Chang, PO Hassa, R Sriburi, S Di Paola, SB Stephens, V Schreiber, Y Kimata   +29 more
core   +1 more source

The Ser/Thr protein kinase FonKin4-poly(ADP-ribose) polymerase FonPARP1 phosphorylation cascade is required for the pathogenicity of watermelon fusarium wilt fungus Fusarium oxysporum f. sp. niveum

Frontiers in Microbiology
Poly(ADP-ribosyl)ation (PARylation), catalyzed by poly(ADP-ribose) polymerases (PARPs) and hydrolyzed by poly(ADP-ribose) glycohydrolase (PARG), is a kind of post-translational protein modification that is involved in various cellular processes in fungi,
Jiajing Wang, Jiajing Wang, Yizhou Gao, Yizhou Gao, Xiaohui Xiong, Xiaohui Xiong, Yuqing Yan, Yuqing Yan, Jiajun Lou, Jiajun Lou, Muhammad Noman, Dayong Li, Dayong Li, Fengming Song, Fengming Song, Fengming Song   +15 more
doaj   +1 more source

Targeting dePARylation for cancer therapy

Cell & Bioscience, 2020
Poly(ADP-ribosyl)ation (PARylation) mediated by poly ADP-ribose polymerases (PARPs) plays a key role in DNA damage repair. Suppression of PARylation by PARP inhibitors impairs DNA damage repair and induces apoptosis of tumor cells with repair defects ...
Muzaffer Ahmad Kassab, Lily L. Yu, Xiaochun Yu   +2 more
doaj   +1 more source

Advances in using PARP inhibitors to treat cancer [PDF]

, 2012
The poly (ADP-ribose) polymerase (PARP) family of enzymes plays a critical role in the maintenance of DNA integrity as part of the base excision pathway of DNA repair. PARP1 is overexpressed in a variety of cancers, and its expression has been associated
Shivaani Kummar, Alice Chen, Ralph E Parchment, Robert J Kinders, Jay Ji, Joseph E Tomaszewski, James H Doroshow   +6 more
core   +1 more source

PARP inhibition prevents escape from a telomere-driven crisis and inhibits cell immortalisation [PDF]

, 2018
Telomeric crisis is the final replicative barrier to cell immortalisation; it is characterised by genome instability and cell death and is triggered when telomeres become critically short and are subjected to fusion. Pre-cancerous lesions, or early stage
Argani, Ashworth, Ashworth, Bacchetti, Bacchetti, Bai, Baird, Baird, Baird, Baird, Baird, Baird, Baird, Baird, Bao, Burkle, Chang, Curtin, Dahm-Daphi, Dantzer, Dantzer, Dantzer, de Bono, de Lange, de Lange, de Lange, de Lange, De Marzo, DePinho, DePinho, Fegan, Fegan, Helleday, Helleday, Hendrickson, Iliakis, Jackson, Jackson, Karlseder, Lehtio, Lieber, Liu, Moroni, Ouellette, Pellat-Deceunynck, Pellicciari, Piwnica-Worms, Pommier, Pommier, Reddel, Robbins, Rottenberg, Salzer, Schuler, Schuler, Sfeir, Smith, Sugano, Weinberg, Wynford-Thomas, Zupi   +60 more
core   +3 more sources

Poly ADP-ribose polymerase-1 and health

Experimental Biology and Medicine, 2010
Niacin (vitamin B3) is required to form nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), which are involved in scores of anabolic and catabolic redox reactions throughout metabolism. It is now understood that NAD+ is also a substrate for several families of ADP-ribosylation reactions, which control ...
openaire   +2 more sources

Flow-cytometric assessment of cellular poly(ADP-ribosyl)ation capacity in peripheral blood lymphocytes

Immunity & Ageing, 2006
Background Poly(ADP-ribosyl)ation is a posttranslational modification of nuclear proteins catalysed by poly(ADP-ribose) polymerases (PARPs), using NAD+ as a substrate.
Hyland Paul, Thaa Bastian, Malaisé Muriel, Annett Kathryn, Liu Dan, Kunzmann Andrea, Barnett Yvonne, Bürkle Alexander   +7 more
doaj   +1 more source