Results 101 to 110 of about 9,722 (255)

Poly ADP-ribose polymerase-1 and health

Experimental Biology and Medicine, 2010
Niacin (vitamin B 3 ) is required to form nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), which are involved in scores of anabolic and catabolic redox reactions throughout metabolism. It is now understood that NAD +
openaire   +2 more sources

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

Rapid regulation of telomere length is mediated by poly(ADP-ribose) polymerase-1 [PDF]

, 2008
Shelterin/telosome is a multi-protein complex at mammalian telomeres, anchored to the double-stranded region by the telomeric-repeat binding factors-1 and -2.
Cohausz, Odile, Boukamp, P, S. Beneke, Cohausz, O, Bürkle, A, Bürkle, Alexander, F. Althaus, A. Bürkle, P. Boukamp, Beneke, Sascha, Malanga, M, O. Cohausz, MALANGA, MARIA, Boukamp, Petra, Beneke, S, Althaus, Felix   +15 more
core   +1 more source

Flow-cytometric assessment of cellular poly(ADP-ribosyl)ation capacity in peripheral blood lymphocytes

Immunity & Ageing, 2006
Background Poly(ADP-ribosyl)ation is a posttranslational modification of nuclear proteins catalysed by poly(ADP-ribose) polymerases (PARPs), using NAD+ as a substrate.
Hyland Paul, Thaa Bastian, Malaisé Muriel, Annett Kathryn, Liu Dan, Kunzmann Andrea, Barnett Yvonne, Bürkle Alexander   +7 more
doaj   +1 more source

Targeting Renal IGFBP7 With Tetrahedral Framework Nucleic Acid‐Delivered siRNA Alleviates Acute Kidney Injury

iNew Medicine, EarlyView.
A tFNA‐based siRNA delivery system targeting IGFBP7 effectively silences IGFBP7 expression and attenuates renal dysfunction, tubular injury, and cell death in both septic (CLP) and ischemic (I/R) murine models of acute kidney injury. ABSTRACT Acute kidney injury (AKI) is a common and serious clinical condition, yet effective targeted therapies remain ...
Shao‐qi Wu, Ying‐ying Gao, Meng‐yi Jia, Yu‐Hao Liu, Qian Zhou, Dong Liu, Yu Ren, Yu‐jie Liu, Feng‐he Li, Ya‐ru Yang, Jie Wang, Jia‐gen Wen   +11 more
wiley   +1 more source

Poly(A) polymerase and poly(ADP-ribose) polymerase activities in normal and crown gall tumor tissue cultures of tobacco

, 1985
Normal and crown gall tumor tissue cultures of tobacco had poly(ADP-ribose) polymerase associated with the chromatin and two poly(A) polymerases (separable by DEAE-Sephadex A-25 chromatography) with the soluble fraction.
D'Alessandro, Michelle, Srivastava, B.I.Sahai, Michelle D'Alessandro, B.I.Sahai Srivastava   +3 more
core   +1 more source

The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase. [PDF]

, 2011
Post-translational modification of proteins by poly(ADP-ribosyl)ation regulates many cellular pathways that are critical for genome stability, including DNA repair, chromatin structure, mitosis and apoptosis.
Ahel, M, Slade, Dea, Ria Weston, Ahel, I, Neil Dixon, David Leys, Mark S. Dunstan, Dea Slade, Eva Barkauskaite, Dixon, N, Pierre Lafite, Dunstan, MS, Ahel, Marijan, Leys, D, Marijan Ahel, Lafite, P, Barkauskaite, Eva, Dunstan, Mark, Ivan Ahel, Weston, Ria, Barkauskaite, E, Weston, R, Ahel, Ivan, Lafite, Pierre, Leys, David, Slade, D, Dixon, Neil   +26 more
core   +1 more source

The TRPM2–PARP‐1 Axis Involvement in Bisphenol A and Nonylphenol‐Induced Ferroptosis in Trigeminal Ganglion Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Environmental contaminants like bisphenol A (BPA) and nonylphenol (NP) are recognized neurotoxicants; however, the molecular mechanisms underlying their impact on sensory ganglia, specifically the trigeminal ganglion (TG), remain critically underexplored.
Betül Yazğan, Musa Tatar, Yener Yazğan, Kıymet Kübra Tüfekci   +3 more
wiley   +1 more source

ART2, a T cell surface mono-ADP-ribosyltransferase, generates extracellular poly(ADP-ribose)

, 2008
Medical student Alan Morrison participated in this study as part of the Senior Scholars research program.NAD functions in multiple aspects of cellular metabolism and signaling through enzymes that covalently transfer ADP-ribose from NAD to acceptor ...
Morrison, Alan R., Moss, Joel, Merithew, Eric Lee, Bortell, Rita, Evans, James E., Farrell, Caitlin, Mordes, John P., Stevens, Linda A., Lambright, David G., Rossini, Aldo A., Greiner, Dale L.   +10 more
core   +1 more source

Poly(ADP-ribose) polymerases regulate cell division and development in Arabidopsis roots [PDF]

, 2017
Root organogenesis involves cell division, differentiation and expansion. The molecular mechanisms regulating root development are not fully understood. In this study, we identified poly (ADP-ribose) polymerases (PARPs) as new players in root development.
Wu, Qiao, Caifeng Liu, Wang, Wenjing, Zongyin Gu, Gu, Zongyin, Liu, Weiwei, Xiaochun Ge, Liu, Caifeng, Qiao Wu, Ping Xu, Ma, Hong, Ge, Xiaochun, Hong Ma, Xu, Ping, Wenjing Wang, Weiwei Liu   +15 more
core   +1 more source