Results 11 to 20 of about 9,722 (255)

Poly(ADP-Ribose) Polymerases in Plants and Their Human Counterparts: Parallels and Peculiarities [PDF]

International Journal of Molecular Sciences, 2019
Poly(ADP-ribosyl)ation is a rapid and transient post-translational protein modification that was described first in mammalian cells. Activated by the sensing of DNA strand breaks, poly(ADP-ribose)polymerase1 (PARP1) transfers ADP-ribose units onto itself
Edgar Peiter
exaly   +5 more sources

Poly(ADP-Ribose) Links the DNA Damage Response and Biomineralization [PDF]

Cell Reports, 2019
Summary: Biomineralization of the extracellular matrix is an essential, regulated process. Inappropriate mineralization of bone and the vasculature has devastating effects on patient health, yet an integrated understanding of the chemical and cell ...
Karin H. Müller, Robert Hayward, Rakesh Rajan, Meredith Whitehead, Andrew M. Cobb, Sadia Ahmad, Mengxi Sun, Ieva Goldberga, Rui Li, Uliana Bashtanova, Anna M. Puszkarska, David G. Reid, Roger A. Brooks, Jeremy N. Skepper, Jayanta Bordoloi, Wing Ying Chow, Hartmut Oschkinat, Alex Groombridge, Oren A. Scherman, James A. Harrison, Anja Verhulst, Patrick C. D’Haese, Ellen Neven, Lisa-Maria Needham, Steven F. Lee, Catherine M. Shanahan, Melinda J. Duer   +26 more
doaj   +2 more sources

The Ups and Downs of Tannins as Inhibitors of Poly(ADP-Ribose)glycohydrolase [PDF]

Molecules, 2011
DNA damage to cells activates nuclear poly(ADP-ribose)polymerases (PARPs) and the poly(ADP-ribose) (PAR) synthesized is rapidly cleaved into ADP-ribose (ADPR) by PAR glycohydrolase (PARG) action.
Felix R. Althaus, Philippe Wyrsch, Christian Blenn   +2 more
doaj   +2 more sources

Selective down-regulation of nuclear poly(ADP-ribose) glycohydrolase. [PDF]

PLoS ONE, 2009
The formation of ADP-ribose polymers on target proteins by poly(ADP-ribose) polymerases serves a variety of cell signaling functions. In addition, extensive activation of poly(ADP-ribose) polymerase-1 (PARP-1) is a dominant cause of cell death in ...
David M Burns, Weihai Ying, Tiina M Kauppinen, Keqing Zhu, Raymond A Swanson   +4 more
doaj   +3 more sources

Sirtuins and their interactions with transcription factors and poly(ADP-ribose) polymerases [PDF]

Folia Neuropathologica, 2016
Sirtuins (SIRT1 to -7) are unique histone deacetylases (HDACs) whose activity depends on NAD+, thus making them capable of sensing the cellular metabolic status.
Henryk Jęśko, Robert P. Strosznajder
doaj   +2 more sources

The Dichotomy of the Poly(ADP-Ribose) Polymerase-Like Thermozyme from Sulfolobus solfataricus [PDF]

Challenges, 2018
The first evidence of an ADP-ribosylating activity in Archaea was obtained in Sulfolobus solfataricus(strain MT-4) where a poly(ADP-ribose) polymerase (PARP)-like thermoprotein, defined with the acronymous PARPSso, was found.
Maria Rosaria Faraone Mennella
doaj   +2 more sources

Poly(ADP-Ribose) Polymerases in Host-Pathogen Interactions, Inflammation, and Immunity [PDF]

Microbiology and Molecular Biology Reviews, 2019
Margaret A Johnson
exaly   +2 more sources

New Facets in the Regulation of Gene Expression by ADP-Ribosylation and Poly(ADP-ribose) Polymerases [PDF]

Chemical Reviews, 2015
Keun Woo Ryu, W Lee Kraus
exaly   +2 more sources

Joining of DNA breaks- interplay between DNA ligases and poly (ADP-ribose) polymerases [PDF]

DNA Repair
Alan E Tomkinson
exaly   +2 more sources

Characterization of an Aedes ADP-Ribosylation Protein Domain and Role of Post-Translational Modification during Chikungunya Virus Infection

Pathogens, 2023
Poly ADP-ribose polymerases (PARPs) catalyze ADP-ribosylation, a subclass of post-translational modification (PTM). Mono-ADP-ribose (MAR) moieties bind to target molecules such as proteins and nucleic acids, and are added as part of the process which ...
Ramesh Kumar, Divya Mehta, Debasis Nayak, Sujatha Sunil   +3 more
doaj   +1 more source