Poly(ADP-Ribose) Links the DNA Damage Response and Biomineralization [PDF]
Cell Reports, 2019 Summary: Biomineralization of the extracellular matrix is an essential, regulated process. Inappropriate mineralization of bone and the vasculature has devastating effects on patient health, yet an integrated understanding of the chemical and cell ...
Karin H. Müller +26 more
doaj +2 more sources
The Ups and Downs of Tannins as Inhibitors of Poly(ADP-Ribose)glycohydrolase [PDF]
Molecules, 2011 DNA damage to cells activates nuclear poly(ADP-ribose)polymerases (PARPs) and the poly(ADP-ribose) (PAR) synthesized is rapidly cleaved into ADP-ribose (ADPR) by PAR glycohydrolase (PARG) action.
Felix R. Althaus +2 more
doaj +2 more sources
Selective down-regulation of nuclear poly(ADP-ribose) glycohydrolase. [PDF]
PLoS ONE, 2009 The formation of ADP-ribose polymers on target proteins by poly(ADP-ribose) polymerases serves a variety of cell signaling functions. In addition, extensive activation of poly(ADP-ribose) polymerase-1 (PARP-1) is a dominant cause of cell death in ...
David M Burns +4 more
doaj +3 more sources
Sirtuins and their interactions with transcription factors and poly(ADP-ribose) polymerases [PDF]
Folia Neuropathologica, 2016 Sirtuins (SIRT1 to -7) are unique histone deacetylases (HDACs) whose activity depends on NAD+, thus making them capable of sensing the cellular metabolic status.
Henryk Jęśko, Robert P. Strosznajder
doaj +2 more sources
Excessive poly(ADP)-ribosylation in the inflamed mucosa of pediatric celiac disease points to a novel inflammatory mechanism and therapeutic target [PDF]
Molecular and Cellular PediatricsBackground Celiac disease (CD) is an immune-mediated enteropathy triggered by gluten exposure in genetically susceptible individuals, characterized by chronic intestinal inflammation, epithelial damage, and immune dysregulation.
Tala M. Haddadin +6 more
doaj +2 more sources
New Facets in the Regulation of Gene Expression by ADP-Ribosylation and Poly(ADP-ribose) Polymerases [PDF]
Chemical Reviews, 2015 Keun Woo Ryu, W Lee Kraus
exaly +2 more sources
ADP-ribosylation: An emerging regulator of the epigenome. [PDF]
Mol OncolADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Camacho CV, Liu C, Kraus WL.
europepmc +2 more sources
Pathogens, 2023 Poly ADP-ribose polymerases (PARPs) catalyze ADP-ribosylation, a subclass of post-translational modification (PTM). Mono-ADP-ribose (MAR) moieties bind to target molecules such as proteins and nucleic acids, and are added as part of the process which ...
Ramesh Kumar +3 more
doaj +1 more source
Selective monitoring of the protein-free ADP-ribose released by ADP-ribosylation reversal enzymes.
PLoS ONE, 2021 ADP-ribosylation is a key post-translational modification that regulates a wide variety of cellular stress responses. The ADP-ribosylation cycle is maintained by writers and erasers.
Samuel Kasson +2 more
doaj +1 more source
Protein poly(ADP-ribosyl)ation regulates arabidopsis immune gene expression and defense responses. [PDF]
PLoS Genetics, 2015 Perception of microbe-associated molecular patterns (MAMPs) elicits transcriptional reprogramming in hosts and activates defense to pathogen attacks. The molecular mechanisms underlying plant pattern-triggered immunity remain elusive.
Baomin Feng +8 more
doaj +1 more source