Results 51 to 60 of about 96,094 (164)

PARP-1 couples β-catenin/TCF4 signaling to epithelial–mesenchymal transition in endometriosis

Scientific Reports
Endometriosis exhibits epithelial–mesenchymal transition (EMT)-aligned traits that promote invasion and lesion persistence. We investigated whether poly(ADP-ribose) polymerase-1 (PARP-1) coordinates β-catenin/TCF4 activity with EMT programs and whether ...
Lu Zhang, Xianli Li, Liang Kong, Xiaoying Hou, Bohan Li, Ying Zhang, Jinjuan Wang   +6 more
doaj   +1 more source

PARP-1 deregulation in multiple sclerosis

Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2019
Background Poly (ADP-ribose) polymerase 1 (PARP-1) plays pivotal roles in immune and inflammatory responses. Accumulating evidence suggests PARP-1 as a promising target for immunomodulation in multiple sclerosis and natalizumab-associated progressive ...
Maria Meira, Claudia Sievers, Francine Hoffmann, Heidi Bodmer, Tobias Derfuss, Jens Kuhle, Aiden Haghikia, Ludwig Kappos, Raija LP Lindberg   +8 more
doaj   +1 more source

Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β

Journal of Neuroinflammation, 2011
Background Amyloid β (Aβ) accumulates in Alzheimer's disease (AD) brain. Microglial activation also occurs in AD, and this inflammatory response may contribute to disease progression.
Kauppinen Tiina M, Suh Sang, Higashi Youichirou, Berman Ari E, Escartin Carole, Won Seok, Wang Chao, Cho Seo-Hyun, Gan Li, Swanson Raymond A   +9 more
doaj   +1 more source

PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration

Cell Communication and Signaling, 2010
The normal function of poly (ADP-ribose) polymerase-1 (PARP-1) is the routine repair of DNA damage by adding poly (ADP ribose) polymers in response to a variety of cellular stresses.
Alexander Jonathan S, Chaitanya Ganta, Babu Phanithi   +2 more
doaj   +1 more source

Multi-stage structure-based virtual screening approach combining 3D pharmacophore, docking and molecular dynamic simulation towards the identification of potential selective PARP-1 inhibitors

BMC Chemistry
Presently, humanity is confronted with a range of diseases that have high death rates, especially those linked to cancerous growths. Several enzymes and proteins have been discovered as highly attractive targets for cancer treatment.
Mahmoud A. El Hassab, Wagdy M. Eldehna, Ghaneya S. Hassan, Sahar M. Abou-Seri   +3 more
doaj   +1 more source

Importin alpha binding and nuclear localization of PARP-2 is dependent on lysine 36, which is located within a predicted classical NLS

BMC Cell Biology, 2008
Background The enzymes responsible for the synthesis of poly-ADP-ribose are named poly-ADP-ribose polymerases (PARP). PARP-2 is a nuclear protein, which regulates a variety of cellular functions that are mainly controlled by protein-protein interactions.
Valovka Taras, Hassa Paul O, Altmeyer Matthias, Haenni Sandra S, Fey Monika, Hottiger Michael O   +5 more
doaj   +1 more source

Non-NAD-Like poly(ADP-Ribose) Polymerase-1 Inhibitors effectively Eliminate Cancer in vivo

EBioMedicine, 2016
The clinical potential of PARP-1 inhibitors has been recognized >10 years ago, prompting intensive research on their pharmacological application in several branches of medicine, particularly in oncology.
Colin Thomas, Yingbiao Ji, Niraj Lodhi, Elena Kotova, Aaron Dan Pinnola, Konstantin Golovine, Peter Makhov, Kate Pechenkina, Vladimir Kolenko, Alexei V. Tulin   +9 more
doaj   +1 more source

The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis

Mediators of Inflammation, 2015
Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme with a crucial role in the maintenance of genomic stability. In addition to the role of PARP-1 in DNA repair, multiple studies have also demonstrated its involvement in several inflammatory ...
Samuel García, Carmen Conde
doaj   +1 more source

Exploring the radiochemistry of PARP inhibitors: a new era in therapy and imaging

EJNMMI Radiopharmacy and Chemistry
Background Poly (ADP-ribose) polymerase (PARP) inhibitors have emerged as a promising class of therapeutics, particularly in the treatment of cancers with defective DNA repair mechanisms, such as those with breast cancer genes (BRCA) mutations.
Gianluca Destro, Rebecca Rizzo, Chiara Rua, Raha Rouhbakhsh Azimi, Silvia Morbelli   +4 more
doaj   +1 more source

Mono-methylated histones control PARP-1 in chromatin and transcription

eLife
PARP-1 is central to transcriptional regulation under both normal and stress conditions, with the governing mechanisms yet to be fully understood. Our biochemical and ChIP-seq-based analyses showed that PARP-1 binds specifically to active histone marks ...
Gbolahan Bamgbose, Guillaume Bordet, Niraj Lodhi, Alexei Tulin   +3 more
doaj   +1 more source