Results 1 to 10 of about 80,955 (206)

Efficacy and safety of PARP inhibitor maintenance therapy in elderly ovarian cancer patients: a real-world single-center retrospective cohort study [PDF]

Frontiers in Oncology
BackgroundPARP(Poly(ADP-ribose) polymerase) inhibitors are established as effective treatment for ovarian cancer; however, there have been no systematic studies of PARP inhibitor use in older patients with ovarian cancer.MethodsThis study was conducted ...
Jingjing Lu, Jingjing Lu, Xuelian Song, Chen Zhang, Yi Zhu, Huarui Yang, Yi Li   +6 more
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Radiosensitization Effect of PARP Inhibitor Talazoparib Involves Decreasing Mitochondrial Membrane Potential and Induction of Cellular Senescence [PDF]

Current Issues in Molecular Biology
Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPis) with radiation therapy can enhance the sensitivity of cancer cells by inhibiting DNA repair pathways.
Barkha Saraswat, Ankitha Vadi Velu, Zhongming Gao, Zongxiang Zhang, Haoyang Zhu, Ying Tong, Mitsuko Masutani   +6 more
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Drug-Induced Interstitial Lung Disease From PARP Inhibitors (Olaparib and Niraparib) for Ovarian Cancer

Annals of Internal Medicine: Clinical Cases, 2023
Poly (ADP-ribose) polymerase (PARP) inhibitors are approved for the treatment of several types of cancers. We report a case of an 80-year-old Japanese woman who developed drug-induced interstitial lung disease (ILD) during treatment with PARP inhibitors (
Hiroshi Sugimoto, Takanori Enomoto, Mamoru Okuno, Naoko Chayahara, Hiroki Morita, Kyosuke Nakata   +5 more
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Combined inhibition of PARP and EZH2 for cancer treatment: Current status, opportunities, and challenges

Frontiers in Pharmacology, 2022
Tumors with BRCA1/2 mutations or homologous recombination repair defects are sensitive to PARP inhibitors through the mechanism of synthetic lethality. Several PARP inhibitors are currently approved for ovarian, breast and pancreatic cancer in clinical ...
Xi Zhang, Xiao Huo, Xiao Huo, Hongyan Guo, Lixiang Xue, Lixiang Xue   +5 more
doaj   +1 more source

In silico screening identifies a novel small molecule inhibitor that counteracts PARP inhibitor resistance in ovarian cancer

Scientific Reports, 2021
Poly ADP-ribose polymerase (PARP) inhibitors are promising targeted therapy for epithelial ovarian cancer (EOC) with BRCA mutations or defective homologous recombination (HR) repair. However, reversion of BRCA mutation and restoration of HR repair in EOC
Z. Ping Lin, Nour N. Al Zouabi, Mark L. Xu, Nicole E. Bowen, Terence L. Wu, Ethan S. Lavi, Pamela H. Huang, Yong-Lian Zhu, Baek Kim, Elena S. Ratner   +9 more
doaj   +1 more source

PARP inhibition promotes ferroptosis via repressing SLC7A11 and synergizes with ferroptosis inducers in BRCA-proficient ovarian cancer

Redox Biology, 2021
Pharmacologic inhibition of PARP is the primary therapeutic strategy for BRCA mutant ovarian cancer. However, most of patients carry wild-type BRCA1/2 with no significant clinical benefits from PARP inhibitors, calling for the needs to further ...
Ting Hong, Guang Lei, Xue Chen, He Li, Xiaoye Zhang, Nayiyuan Wu, Yu Zhao, Yilei Zhang, Jing Wang   +8 more
doaj   +1 more source

A ribosomal gene panel predicting a novel synthetic lethality in non-BRCAness tumors

Signal Transduction and Targeted Therapy, 2023
Poly (ADP-ribose) polymerase (PARP) inhibitors are one of the most exciting classes of targeted therapy agents for cancers with homologous recombination (HR) deficiency.
Chao Zhang, Qiang Guo, Lifeng Chen, Zheming Wu, Xiao-Jian Yan, Chengyang Zou, Qiuxue Zhang, Jiahong Tan, Tian Fang, Qunxian Rao, Yang Li, Shizhen Shen, Min Deng, Liewei Wang, Huanyao Gao, Jia Yu, Hu Li, Cheng Zhang, Somaira Nowsheen, Jake Kloeber, Fei Zhao, Ping Yin, Chunbo Teng, Zhongqiu Lin, Kun Song, Shuzhong Yao, Liangqing Yao, Lingying Wu, Yong Zhang, Xiaodong Cheng, Qinglei Gao, Jian Yuan, Zhenkun Lou, Jin-San Zhang   +33 more
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99529 The Role of ATF6-Mediated Signaling in PARP Inhibitor Resistant Ovarian Cancer

Journal of Clinical and Translational Science, 2021
IMPACT: This work has the potential to identify targetable pathways conveying resistance to PARP inhibitors that may improve ovarian cancer patient outcomes. OBJECTIVES/GOALS: High grade serous ovarian cancer is the deadliest gynecologic malignancy. PARP
Alexandra, Benjamin Bitler
doaj   +1 more source

PALB2 or BARD1 loss confers homologous recombination deficiency and PARP inhibitor sensitivity in prostate cancer

npj Precision Oncology, 2022
PARP inhibitors were recently approved for treatment of molecularly-defined subsets of metastatic castrate-resistant prostate cancer (mCRPC) patients.
Kasia M. Dillon, Raie T. Bekele, Zsofia Sztupinszki, Timothy Hanlon, Shahrzad Rafiei, Zoltan Szallasi, Atish D. Choudhury, Kent W. Mouw   +7 more
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Effects of poly (ADP-ribose) polymerase-1 (PARP-1) inhibition on sulfur mustard-induced cutaneous injuries in vitro and in vivo [PDF]

PeerJ, 2016
Early studies with first-generation poly (ADP-ribose) polymerase (PARP) inhibitors have already indicated some therapeutic potential for sulfur mustard (SM) injuries.
Feng Liu, Ning Jiang, Zhi-yong Xiao, Jun-ping Cheng, Yi-zhou Mei, Pan Zheng, Li Wang, Xiao-rui Zhang, Xin-bo Zhou, Wen-xia Zhou, Yong-xiang Zhang   +10 more
doaj   +2 more sources