The PARP-1 inhibitor Olaparib causes retention of γ-H2AX foci in BRCA1 heterozygote cells following exposure to gamma radiation [PDF]
, 2013 This article is made available through the Brunel Open Access Publishing Fund. Copyright © 2013 Emma C. Bourton et al. This is an open access article distributed under the Creative Commons Attribution Li-cense, which permits unrestricted use ...
Bourton, EC +4 more
core +1 more source
Frontiers in Cellular Neuroscience, 2020 Post-stroke inflammation is almost involved in the whole process of stroke pathogenesis, which serves as a prime target for developing new stroke therapies. Despite known sex differences in the incidence and outcome of stroke, few preclinical or clinical
Jian Chen +19 more
doaj +1 more source
PARP inhibitors in ovarian cancer [PDF]
Cancer Treatment Reviews, 2019 Poly-ADP-ribosepolymerase inhibitors (PARPis) are the most active and interesting therapies approved for the treatment of epithelial ovarian cancer. They have changed the clinical management of a disease characterized, in almost half of cases, by extreme genetic complexity and alteration of DNA damage repair pathways, particularly homologous ...
Franzese, Elisena +9 more
openaire +3 more sources
Effect of MRE11 loss on PARP-inhibitor sensitivity in endometrial cancer in vitro. [PDF]
PLoS ONE, 2014 AIM OF THE STUDY:To evaluate the frequency of MRE11/RAD50/NBS1 (MRN)-complex loss of protein expression in endometrial cancers (EC) and to determine whether loss of MRE11 renders the cancer cells sensitive to Poly(ADP-ribose) polymerase (PARP)-inhibitory
Romana Koppensteiner +11 more
doaj +1 more source
Revealing the selective mechanisms of inhibitors to PARP-1 and PARP-2 via multiple computational methods [PDF]
PeerJ, 2020 Background Research has shown that Poly-ADP-ribose polymerases 1 (PARP-1) is a potential therapeutic target in the clinical treatment of breast cancer.
Hongye Hu +3 more
doaj +2 more sources
A preliminary study on the synthetic lethal effect of berberine and olaparib on pancreatic cancer cells and its mechanism [PDF]
E3S Web of Conferences, 2021 Pancreatic cancer is a kind of malignant tumor with high mortality rate. Early operation and late chemoradiotherapy are the treatment criteria, but the prognosis is still poor.
Zhang Chengyong +9 more
doaj +1 more source
PARP Inhibitors for Chemoprevention—Letter [PDF]
Cancer Prevention Research, 2014 We read with great optimism To and colleagues' ([1][1]) article about PARP inhibitors as effective chemopreventive strategy for treating homologous repair (HR)–deficient tumors. Their overarching conclusion stated in the discussion is that “…synthetic lethality (i.e., PARP inhibitor ...
Saswati N, Chand +8 more
openaire +2 more sources
Effects of alcohol and PARP inhibition on RNA ribosomal engagement in cortical excitatory neurons
Frontiers in Molecular Neuroscience, 2023 We report on the effects of ethanol (EtOH) and Poly (ADP-ribose) polymerase (PARP) inhibition on RNA ribosomal engagement, as a proxy for protein translation, in prefrontal cortical (PFC) pyramidal neurons.
Harish R. Krishnan +10 more
doaj +1 more source
PARP inhibitors in ovarian cancer: evidence, experience and clinical potential
Therapeutic Advances in Medical Oncology, 2017 Inhibitors of poly(ADP-ribose) polymerase (PARP) are considered one of the most active and exciting new therapies for the treatment of ovarian cancer.
Tarra Evans, Ursula Matulonis
doaj +1 more source
Mitotic Spindle +/- PARP inhibitor Olaparib
, 2022 Epimastigotes synchronized (images correpond to the G2-M phase of the cycle) incubated in the presence of DMSO control (Figures 1-28) or in the presence of 100 nM Olaparib PARP inhibitor (Figures 27-41). Spindle is visualized with antitubulin antibody.
Laura Kevorkian (13577728)
core +1 more source