Poly(ADP-Ribose)Polymerase-1 in Lung Inflammatory Disorders: A Review [PDF]
Frontiers in Immunology, 2017 Asthma, acute lung injury (ALI), and chronic obstructive pulmonary disease (COPD) are lung inflammatory disorders with a common outcome, that is, difficulty in breathing. Corticosteroids, a class of potent anti-inflammatory drugs, have shown less success
Gurupreet S. Sethi +2 more
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PARP1 (poly(ADP-ribose) polymerase 1) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2020 PARP1 (poly(ADP-ribose) polymerase 1) is a nuclear protein involved in the regulation of various biological processes including apoptosis, DNA repair for the maintenance of genome integrity, epigenetic marking of chromatin, assembly of higher-order chromatin structures, transcriptional activation, differentiation, proliferation, and cell cycle ...
Tunçer, Sinem, Kavak, Kubra
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Poly(ADP-ribose)polymerase activity controls plant growth by promoting leaf cell number [PDF]
, 2014 A changing global environment, rising population and increasing demand for biofuels are challenging agriculture and creating a need for technologies to increase biomass production.
Claeys, Hannes +8 more
core +12 more sources
Cas9 is mostly orthogonal to human systems of DNA break sensing and repair.
PLoS ONE, 2023 CRISPR/Cas9 system is а powerful gene editing tool based on the RNA-guided cleavage of target DNA. The Cas9 activity can be modulated by proteins involved in DNA damage signalling and repair due to their interaction with double- and single-strand breaks (
Ekaterina A Maltseva +9 more
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Chronic PARP-1 inhibition reduces carotid vessel remodeling and oxidative damage of the dorsal hippocampus in spontaneously hypertensive rats. [PDF]
PLoS ONE, 2017 Vascular remodeling during chronic hypertension may impair the supply of tissues with oxygen, glucose and other compounds, potentially unleashing deleterious effects.
Krisztian Eros +10 more
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Protein poly(ADP-ribosyl)ation regulates arabidopsis immune gene expression and defense responses. [PDF]
PLoS Genetics, 2015 Perception of microbe-associated molecular patterns (MAMPs) elicits transcriptional reprogramming in hosts and activates defense to pathogen attacks. The molecular mechanisms underlying plant pattern-triggered immunity remain elusive.
Baomin Feng +8 more
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Selective down-regulation of nuclear poly(ADP-ribose) glycohydrolase. [PDF]
PLoS ONE, 2009 The formation of ADP-ribose polymers on target proteins by poly(ADP-ribose) polymerases serves a variety of cell signaling functions. In addition, extensive activation of poly(ADP-ribose) polymerase-1 (PARP-1) is a dominant cause of cell death in ...
David M Burns +4 more
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Mitochondria are devoid of poly(ADP‐ribose)polymerase‐1, but harbor its product oligo(ADP‐ribose) [PDF]
Journal of Cellular Biochemistry, 2021 AbstractThere are conflicting data about localization of poly(ADP‐ribose)polymerase‐1 and its product poly(ADP‐ribose) in mitochondria. To finally clarify the discussion, we investigated with biochemical and cell biological methods the potential presence of poly(ADP‐ribose) polymerase‐1 in these organelles.
Julia Köritzer +3 more
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Poly(ADP-ribose) polymerase-1 modulates Nrf2-dependent transcription [PDF]
Free Radical Biology and Medicine, 2014 The basic leucine zipper transcription factor Nrf2 has emerged as a master regulator of intracellular redox homeostasis by controlling the expression of a battery of redox-balancing antioxidants and phase II detoxification enzymes. Under oxidative stress conditions, Nrf2 is induced at the protein level through redox-sensitive modifications on critical ...
Tongde, Wu +5 more
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Chromatin composition is changed by poly(ADP-ribosyl)ation during chromatin immunoprecipitation. [PDF]
PLoS ONE, 2012 Chromatin-immunoprecipitation (ChIP) employs generally a mild formaldehyde cross-linking step, which is followed by isolation of specific protein-DNA complexes and subsequent PCR testing, to analyze DNA-protein interactions.
Sascha Beneke +4 more
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