Results 11 to 20 of about 61,707 (214)
Chromatin composition is changed by poly(ADP-ribosyl)ation during chromatin immunoprecipitation. [PDF]
PLoS ONE, 2012 Chromatin-immunoprecipitation (ChIP) employs generally a mild formaldehyde cross-linking step, which is followed by isolation of specific protein-DNA complexes and subsequent PCR testing, to analyze DNA-protein interactions.
Sascha Beneke +4 more
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PLoS ONE, 2014 Poly(ADP-ribose)polymerase and sirtuin 1 are both NAD(+)-dependent enzymes. In vitro oxidative stress activates poly(ADP-ribose)polymerase, decreases NAD(+) level, sirtuin 1 activity and finally leads to cell death.
Cindy Gueguen +4 more
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Structural modeling of NAD+ binding modes to PARP-1
Вавиловский журнал генетики и селекции, 2017 The nuclear protein poly (ADP-ribose) polymerase-1 (PARP-1) plays an important role in the signaling and repair of DNA. PARP-1 catalyses covalent binding of poly (ADP-ribose) polymers with itself as well as with other acceptor proteins using NAD+ as a ...
N. V. Ivanisenko +2 more
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Recruitment of ubiquitin-activating enzyme UBA1 to DNA by poly(ADP-ribose) promotes ATR signalling
Life Science Alliance, 2018 Human but not yeast UBA1 binds poly(ADP-ribose) polymers via a solvent-exposed and positively charged patch. Poly(ADP-ribose) polymerase 1–dependent recruitment of UBA1 to DNA ensures ataxia-telangiectasia and RAD3-related activation.
Ramhari Kumbhar +8 more
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Cells, 2019 Increased DNA damage and the propension to cancer development, depend on the modulation of the mechanisms to control and maintain genomic integrity. Poly(ADP-Ribose)Polymerase activation and automodification are early responses to genotoxic stress.
Serena Imperato +5 more
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HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones
Nature Communications, 2021 Once DNA breaks occur, poly(ADP-ribose) polymerase 1 (PARP1) ADP-ribosylates itself and other DNA repair factors to initiate the repair process. Here, the authors resolve the crystal structures of mouse and human HPF1, and human HPF1/PARP1 complex ...
Fa-Hui Sun +5 more
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Mcl-1 suppresses abasic site repair following bile acid–induced hepatic cellular DNA damage
Tumor Biology, 2017 In cholestasis, increases in bile acid levels result in the generation of reactive oxygen species and the induction of DNA damage and mutation. It is believed that bile acid accumulation is associated with liver tumorigenesis. However, the mechanism that
Haiyang Yu +11 more
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Nitrosative Stress as a Modulator of Inflammatory Change in a Model of Takotsubo Syndrome
JACC: Basic to Translational Science, 2018 Summary: Previous studies have shown that patients with Takotsubo syndrome (TS) have supranormal nitric oxide signaling, and post-mortem studies of TS heart samples revealed nitrosative stress.
Sven Y. Surikow, BHlthSc (Hons) +15 more
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Electrochemical Methods for the Detection of Poly(ADP-ribose) Polymerase-1
International Journal of Electrochemical Science, 2021 Poly(ADP-ribose) polymerase-1 (PARP-1) plays an important role in DNA repair and apoptosis. The enzyme has been regarded as the biomarker for many diseases including cancer.
Ting Sun, Yanying Li, Feng Zhao
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Inputs and outputs of poly(ADP-ribosyl)ation: Relevance to oxidative stress
Redox Biology, 2014 Oxidative stress can cause DNA breaks which induce activation of the DNA nick sensor enzyme poly(ADP-ribose) polymerase-1 (PARP-1), part of the 17 member PARP enzyme family.
Csaba Hegedűs, László Virág
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