Inhibition of Poly(ADP-Ribose) polymerase enhances the toxicity of 131I-Metaiodobenzylguanidine/Topotecan combination therapy to cells and xenografts that express the noradrenaline transporter [PDF]
, 2012 Targeted radiotherapy using [131I]meta-iodobenzylguanidine ([131I]MIBG) has produced remissions in some neuroblastoma patients. We previously reported that combining [131I]MIBG with the topoisomerase I (Topo-I) inhibitor topotecan induced long-term DNA ...
McCluskey, Anthony G +7 more
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Poly(ADP-ribose) polymerase family member 14 (PARP14) is a novel effector of the JNK2-dependent pro-survival signal in multiple myeloma [PDF]
, 2013 Copyright @ 2013 Macmillan Publishers Limited. This is the author's accepted manuscript. The final published article is available from the link below.Regulation of cell survival is a key part of the pathogenesis of multiple myeloma (MM).
Papa, S +9 more
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HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones
Nature Communications, 2021 Once DNA breaks occur, poly(ADP-ribose) polymerase 1 (PARP1) ADP-ribosylates itself and other DNA repair factors to initiate the repair process. Here, the authors resolve the crystal structures of mouse and human HPF1, and human HPF1/PARP1 complex ...
Fa-Hui Sun +5 more
doaj +1 more source
Mcl-1 suppresses abasic site repair following bile acid–induced hepatic cellular DNA damage
Tumor Biology, 2017 In cholestasis, increases in bile acid levels result in the generation of reactive oxygen species and the induction of DNA damage and mutation. It is believed that bile acid accumulation is associated with liver tumorigenesis. However, the mechanism that
Haiyang Yu +11 more
doaj +1 more source
Nitrosative Stress as a Modulator of Inflammatory Change in a Model of Takotsubo Syndrome
JACC: Basic to Translational Science, 2018 Summary: Previous studies have shown that patients with Takotsubo syndrome (TS) have supranormal nitric oxide signaling, and post-mortem studies of TS heart samples revealed nitrosative stress.
Sven Y. Surikow, BHlthSc (Hons) +15 more
doaj +1 more source
Inputs and outputs of poly(ADP-ribosyl)ation: Relevance to oxidative stress
Redox Biology, 2014 Oxidative stress can cause DNA breaks which induce activation of the DNA nick sensor enzyme poly(ADP-ribose) polymerase-1 (PARP-1), part of the 17 member PARP enzyme family.
Csaba Hegedűs, László Virág
doaj +1 more source
Electrochemical Methods for the Detection of Poly(ADP-ribose) Polymerase-1
International Journal of Electrochemical Science, 2021 Poly(ADP-ribose) polymerase-1 (PARP-1) plays an important role in DNA repair and apoptosis. The enzyme has been regarded as the biomarker for many diseases including cancer.
Ting Sun, Yanying Li, Feng Zhao
doaj +1 more source
Mitochondria are devoid of poly(ADP‐ribose)polymerase‐1, but harbor its product oligo(ADP‐ribose)
, 2021 There are conflicting data about localization of poly(ADP-ribose)polymerase-1 and its product poly(ADP-ribose) in mitochondria. To finally clarify the discussion, we investigated with biochemical and cell biological methods the potential presence of poly(
Christian Blenn +7 more
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Tricyclic benzimidazoles as potent poly(ADP-ribose) polymerase-1 inhibitors
, 2003 Novel tricyclic benzimidazole carboxamide poly-(ADP-ribose) polymerase-1 (PARP-1) inhibitors have been synthesized. Several compounds were found to be powerful chemopotentiators of temozolomide and topotecan in both A549 and LoVo cell lines.
D. R. +28 more
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Pyridazine Based Compounds with PARP-1 Inhibitory Activity
Archives of Pharmaceutical Sciences Ain Shams University, 2023 Pyridazine-containing compounds have been identified as potent PARP1 inhibitors. The PARP is a family of enzymes essential for many cellular processes such as DNA repair, genomic stability, and apoptosis, also known as poly(ADP-ribose) synthetases and ...
Norhan A. Abdelrahman +3 more
doaj +1 more source