Results 11 to 20 of about 32,646 (215)

Interactions of PARP1 Inhibitors with PARP1-Nucleosome Complexes

Cells, 2022
Inhibitors (PARPi) of poly(ADP-ribose-)polymerase-1 (PARP1) are used in antitumor therapy; their cytotoxicity correlates with the efficiency of PARP1 trapping in cell chromatin.
Natalya Maluchenko, Darya Koshkina, Anna Korovina, Vasily Studitsky, Alexey Feofanov   +4 more
doaj   +3 more sources

Nucleophagy removes cytotoxic trapped PARP1 [PDF]

Nature Cell Biology
Abstract Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPi) induce cytotoxicity in homologous recombination repair (HR)-deficient (HRD) cancers by trapping PARP1 on chromatin, thereby causing irreparable replication-associated DNA damage. Although increased clearance of trapped PARP1 from chromatin reduces the sensitivity of cancer
Gwendoline Hoslett, Sara Tribble, Pauline Lascaux, Stelios Koukouravas, Ignacio Torrecilla, Wei Song, Cynthia X. Hou, Junyi Li, Martín González-Fernández, Giuliana De Gregoriis, Rebecca A. Dagg, Darragh O’Brien, Andrea Pierangelini, Thibaud Martial, Alvin Wei Tian Ng, Nuno Raimundo, Ira Milosevic, Raimundo Freire, Yuliang Li, Sven Rottenberg, Dragomir B. Krastev, Christopher J. Lord, Madalena Tarsounas, Kristijan Ramadan   +23 more
openaire   +2 more sources

Vascular Protection of Poly(ADP-ribose) Polymerase Inhibitors in the Combination Therapy With Vascular Endothelial Growth Factor Signaling Pathway Inhibitors [PDF]

Reviews in Cardiovascular Medicine
The Poly(ADP-ribose) polymerase (PARP) family comprises seventeen members that catalyze poly- or mono- adenosine diphosphate (ADP)-ribosylation, a pivotal post-translational modification regulating a wide array of cellular processes, including ...
Jie Ma, Caie Li, Wenjuan Wang, Xin Fan, Taotao Wei, Xin Ma, Yingdong Wang, Chuyan Feng, Jing Yu   +8 more
doaj   +2 more sources

Mechanisms of Nucleosome Reorganization by PARP1 [PDF]

International Journal of Molecular Sciences, 2021
Poly(ADP-ribose) polymerase 1 (PARP1) is an enzyme involved in DNA repair, chromatin organization and transcription. During transcription initiation, PARP1 interacts with gene promoters where it binds to nucleosomes, replaces linker histone H1 and participates in gene regulation.
Natalya V. Maluchenko, Dmitry K. Nilov, Sergey V. Pushkarev, Elena Y. Kotova, Nadezhda S. Gerasimova, Mikhail P. Kirpichnikov, Marie-France Langelier, John M. Pascal, Md. Sohail Akhtar, Alexey V. Feofanov, Vasily M. Studitsky   +10 more
openaire   +2 more sources

Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation [PDF]

Nature Chemical Biology, 2019
PARP1 inhibitors (PARPi) are known to kill tumor cells via two mechanisms (PARP1 catalytic inhibition and PARP1 trapping). The relative contribution of these two pathways in mediating the cytotoxicity of PARPi, however, is not well understood. Here we designed a series of small molecule PARP degraders.
Shuai Wang, Lei Han, Jungsoo Han, Peng Li, Qing Ding, Qing-Jun Zhang, Zhi-Ping Liu, Chuo Chen, Yonghao Yu   +8 more
openaire   +2 more sources

The Nucleolus and PARP1 in Cancer Biology [PDF]

Cancers, 2020
The nucleolus has been known for a long time to fulfill crucial functions in ribosome biogenesis, of which cancer cells can become addicted to in order to produce sufficient amounts of proteins for cell proliferation. Recently, the nucleolus has emerged as a central regulatory hub in many other cancer-relevant processes, including stress sensing, DNA ...
Engbrecht, Marina, Mangerich, Aswin
openaire   +3 more sources

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

Poly(ADP-Ribose) Polymerase-1 Lacking Enzymatic Activity Is Not Compatible with Mouse Development

Cells, 2023
Poly(ADP-ribose) polymerase-1 (PARP1) binds DNA lesions to catalyse poly(ADP-ribosyl)ation (PARylation) using NAD+ as a substrate. PARP1 plays multiple roles in cellular activities, including DNA repair, transcription, cell death, and chromatin ...
Tatiana Kamaletdinova, Wen Zong, Pavel Urbánek, Sijia Wang, Mara Sannai, Paulius Grigaravičius, Wenli Sun, Zahra Fanaei-Kahrani, Aswin Mangerich, Michael O. Hottiger, Tangliang Li, Zhao-Qi Wang   +11 more
doaj   +1 more source

PAR recognition by PARP1 regulates DNA‐dependent activities and independently stimulates catalytic activity of PARP1 [PDF]

The FEBS Journal, 2021
Poly(ADP‐ribosyl)ation is predominantly catalyzed by Poly(ADP‐ribose) polymerase 1 (PARP1) in response to DNA damage, mediating the DNA repair process to maintain genomic integrity. Single‐strand (SSB) and double‐strand (DSB) DNA breaks are bona fide stimulators of PARP1 activity. However, PAR‐mediated PARP1 regulation remains unexplored.
Waghela Deeksha, Suman Abhishek, Eerappa Rajakumara   +2 more
openaire   +3 more sources

PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response

eLife, 2020
It is being increasingly appreciated that the immunomodulatory functions of PARP1 inhibitors (PARPi) underlie their clinical activities in various BRCA-mutated tumors. PARPi possess both PARP1 inhibition and PARP1 trapping activities.
Chiho Kim, Xu-Dong Wang, Yonghao Yu
doaj   +1 more source