Results 11 to 20 of about 55,025 (289)

Muscle PARP1 inhibition extends lifespan through AMPKα PARylation and activation in Drosophila

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance The activity of PARP1 was increased in the skeletal muscle of aged humans, mice, and Drosophila. The knockdown of PARP1, specifically in muscle, extended the lifespan of Drosophila.
Shanshan Guo, Shuang Zhang, Yixiao Zhuang   +2 more
exaly   +2 more sources

FANCJ promotes PARP1 activity during DNA replication that is essential in BRCA1 deficient cells

Nature Communications
The effectiveness of poly (ADP-ribose) polymerase inhibitors (PARPi) in creating single-stranded DNA gaps and inducing sensitivity requires the FANCJ DNA helicase. Yet, how FANCJ relates to PARP1 inhibition or trapping, which contribute to PARPi toxicity,
Ke Cong, Nathan MacGilvary, Silviana Lee, Shannon G. MacLeod, Jennifer Calvo, Min Peng, Arne Nedergaard Kousholt, Tovah A. Day, Sharon B. Cantor   +8 more
doaj   +2 more sources

PARP1 is required for chromosomal translocations

Blood, 2013
Key Points Chromosomal translocations are mediated by PARP1 and can be suppressed by the clinical PARP1 inhibitors.
Christopher R Cogle, David M Weinstock, Suk-Hee Lee   +2 more
exaly   +4 more sources

Visualization of a DNA-PK/PARP1 complex [PDF]

Nucleic Acids Research, 2012
The DNA-dependent protein kinase (DNA-PK) and Poly(ADP-ribose) polymerase-1 (PARP1) are critical enzymes that reduce genomic damage caused by DNA lesions.
Barbeau, Jody, Curtin, Nicola J, Morris, Edward P, Pearl, Laurence H, Spagnolo, Laura   +4 more
core   +7 more sources

A unified mechanism for PARP inhibitor-induced PARP1 chromatin retention at DNA damage sites in living cells

Cell Reports
Summary: Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPis) not only suppress PARP1 catalytic activity but also prolong its association to damaged chromatin.
Petar-Bogomil Kanev, Sylvia Varhoshkova, Irina Georgieva, Maria Lukarska, Dilyana Kirova, Georgi Danovski, Stoyno Stoynov, Radoslav Aleksandrov   +7 more
doaj   +2 more sources

PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation

EMBO Reports
Poly(ADP-ribose) polymerase 1 (PARP1) is one of the first responders to DNA damage and plays crucial roles in recruiting DNA repair proteins through its activity – poly(ADP-ribosyl)ation (PARylation). The enrichment of DNA repair proteins at sites of DNA
Christopher Chin Sang, Gaelen Moore, Maria Tereshchenko, Hongshan Zhang, Michael L Nosella, Morgan Dasovich, T Reid Alderson, Anthony K L Leung, Ilya J Finkelstein, Julie D Forman-Kay, Hyun O Lee   +10 more
doaj   +3 more sources

USP1 promotes cholangiocarcinoma progression by deubiquitinating PARP1 to prevent its proteasomal degradation

Cell Death and Disease, 2023
Despite its involvement in various cancers, the function of the deubiquitinase USP1 (ubiquitin-specific protease 1) is unexplored in cholangiocarcinoma (CCA). In this study, we provide evidence that USP1 promotes CCA progression through the stabilization
Deng Yong Zhang, Yan Zhu, Qiong Wu, Shuoshuo Ma, Yang Ma, Zheng chao Shen, Zhonglin Wang, Wanliang Sun, Yong Chun Zhou, Dongdong Wang, Shuo Zhou, Zhong Liu, Lawrence N. Kwong, Zheng Lu   +13 more
doaj   +2 more sources

Nucleosome unwrapping and PARP1 allostery drive affinities for chromatin and DNA breaks [PDF]

Nature Communications
Poly(ADP-ribose) polymerase 1 (PARP1) detects DNA strand breaks that occur in duplex DNA and chromatin. Here, correlative optical tweezers and fluorescence microscopy reveal how single molecules of PARP1 identify single-strand breaks (i.e., nicks ...
Matthew A. Schaich, Tyler M. Weaver, Jennifer A. Rakowski, Vera Roginskaya, Liam P. Leary, Aafke A. Van den Berg, Janet H. Iwasa, Bret D. Freudenthal, Bennett Van Houten   +8 more
doaj   +2 more sources

THE PEPTIDOGLYCAN FRACTION ENRICHED WITH MURAMYL PENTAPEPTIDE FROM Lactobacillus bulgaricus INHIBITS GLIOBLASTOMA U373MG CELL MIGRATION CAPABILITY AND UPREGULATES PARP1 AND NF-kB LEVELS [PDF]

Biotechnologia Acta, 2020
Peptidoglycan is a universal component of bacterial walls that exerts various biological activities, including tumoricidal effect. Anti-cancer effect of various peptidoglycan fractions and their derivates is different.
V. S. Nedzvetsky, C. A. Agca, G. Baydas
doaj   +1 more source

Mechanisms of Nucleosome Reorganization by PARP1 [PDF]

International Journal of Molecular Sciences, 2021
Poly(ADP-ribose) polymerase 1 (PARP1) is an enzyme involved in DNA repair, chromatin organization and transcription. During transcription initiation, PARP1 interacts with gene promoters where it binds to nucleosomes, replaces linker histone H1 and participates in gene regulation.
Natalya V. Maluchenko, Dmitry K. Nilov, Sergey V. Pushkarev, Elena Y. Kotova, Nadezhda S. Gerasimova, Mikhail P. Kirpichnikov, Marie-France Langelier, John M. Pascal, Md. Sohail Akhtar, Alexey V. Feofanov, Vasily M. Studitsky   +10 more
openaire   +2 more sources