Results 11 to 20 of about 6,651 (207)
Understanding roles for PARP1 in skeletal muscle [PDF]
, 2023 Depletion of Nicotinamide adenine dinucleotide (NAD+), a critical cofactor in biochemical reactions, is ascribed to metabolic dysfunction and poor quality of life.
Tan, A
core +5 more sources
iScience, 2023 Summary: PARP1 contributes to genome architecture and DNA damage repair through its dynamic association with chromatin. PARP1 and PARP2 (PARP1/2) recognize damaged DNA and recruit the DNA repair machinery.
Jyothi Mahadevan +6 more
doaj +1 more source
Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation [PDF]
Nature Chemical Biology, 2019 PARP1 inhibitors (PARPi) are known to kill tumor cells via two mechanisms (PARP1 catalytic inhibition and PARP1 trapping). The relative contribution of these two pathways in mediating the cytotoxicity of PARPi, however, is not well understood. Here we designed a series of small molecule PARP degraders.
Shuai Wang +8 more
openaire +2 more sources
Molecules, 2023 The protein PARP1, which plays a crucial role in DNA repair processes, is an attractive target for cancer therapy, especially for BRCA-deficient cancers.
Fengqin Yan +3 more
doaj +1 more source
Generierung einer PARP1-Knockout Zelllinie zur Charakterisierung der Rolle von PARP1 in der DNA-Schadensantwort [PDF]
, 2021 Die Poly(ADP-Ribose)-Polymerase 1 (PARP1) spielt eine multifunktionale Rolle in der DNA-Schadensantwort (DDR) und gilt als Schlüsselprotein für die Aufrechterhaltung der genomischen Stabilität.
Gajewski, Sabine
core +1 more source
Folia Neuropathologica, 2020 Trauma is the main cause of death for people aged 1-45, and among them, traumatic brain injury (TBI) is the major condition, which causes over 50,000 deaths each year and costs over 80 billion per year.
Yiqiang Cao +4 more
doaj +1 more source
The Nucleolus and PARP1 in Cancer Biology [PDF]
Cancers, 2020 The nucleolus has been known for a long time to fulfill crucial functions in ribosome biogenesis, of which cancer cells can become addicted to in order to produce sufficient amounts of proteins for cell proliferation. Recently, the nucleolus has emerged as a central regulatory hub in many other cancer-relevant processes, including stress sensing, DNA ...
Engbrecht, Marina, Mangerich, Aswin
openaire +3 more sources
Advanced Science, 2022 Poly (ADP‐ribose) polymerase 1 (PARP1) plays a fundamental role in DNA repair and gene expression. Excessive PARP1 hyperactivation, however, has been associated with cell death. PARP1 and/or its activity are dysregulated in the immune and central nervous
Yan Wang +3 more
doaj +1 more source
Trial watch: STING agonists in cancer therapy
OncoImmunology, 2020 Stimulator of interferon response cGAMP interactor 1 (STING1, best known as STING) is an endoplasmic reticulum-sessile protein that serves as a signaling hub, receiving input from several pattern recognition receptors, most of which sense ectopic DNA ...
Julie Le Naour +4 more
doaj +1 more source
Proteogenomic characterization of cholangiocarcinoma
Hepatology, EarlyView., 2022 Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng +18 more
wiley +1 more source