Results 151 to 160 of about 25,426 (206)

Novel ATR/PARP1 Dual Inhibitors Demonstrate Synergistic Antitumor Efficacy in Triple‐Negative Breast Cancer Models

Advanced Science
Concomitant inhibition of ataxia telangiectasia and Rad3‐related protein (ATR) and poly ADP‐ribose Polymerase (PARP) pathways is a promising strategy in cancer therapy, potentially expanding the clinical utility of ATR inhibitor (ATRi) and PARP inhibitor
Yuan Gao, Jiawei Zhou, Chen‐Chen Wang, Zong‐Hao Wang, Nian‐Dong Mao, Meng‐Lan He, Peng‐Peng Zhang, Ping Huang, Guo‐Wei Ye, Yu‐Qing Zhang, Feng‐Hui Tang, Hang Zhang, Tian Xie, Xiang‐Yang Ye   +13 more
doaj   +1 more source

Cancer Cell-Automomous Inhibition of PARP1 Improves Immunosurveillance

L'inhibition de PARP1 autonome des cellules cancéreuses améliore l'immunosurveillance La poly(ADP-ribose) polymérase 1 (PARP1) est une enzyme dont l’activité élevée dans les cancers pulmonaires non à petites cellules (CPNPC) chez l’homme est de mauvais pronostic et corrélée à une faible infiltration tumorale de lymphocytes cytotoxiques.
openaire   +2 more sources

Combined EGFR1 and PARP1 Inhibition Enhances the Effect of Radiation in Head and Neck Squamous Cell Carcinoma Models. [PDF]

Radiat Res, 2020
Frederick BA, Gupta R, Atilano-Roque A, Su TT, Raben D.   +4 more
europepmc   +1 more source

MAPK4 deletion enhances radiation effects and triggers synergistic lethality with simultaneous PARP1 inhibition in cervical cancer. [PDF]

J Exp Clin Cancer Res, 2020
Tian S, Lou L, Tian M, Lu G, Tian J, Chen X.   +5 more
europepmc   +1 more source

PARP1 inhibition in naïve mouse embryonic stem cells induces viral mimicry. [PDF]

Nucleic Acids Res
Xu J, Schwarz SD, Gunasekera K, Steinacher R, Kuśnierczyk A, Hottiger MO, Schär P.   +6 more
europepmc   +1 more source

PARP1 inhibition mediates a switch from necrosis to senescence that favors repair from acute oxidative injury

, 2023
Nehme J, Mesilmany L, Farfariello V, Varela-Eirin M, Lin Y, Costa MG, Seelen M, Hillebrands J, Goor Hv, Saab R, Prevarskaya N, Akl H, Demaria M.   +12 more
europepmc   +1 more source

CRISPR/Cas9-mediated mutagenesis to validate the synergy between PARP1 inhibition and chemotherapy in BRCA1-mutated breast cancer cells. [PDF]

Bioeng Transl Med, 2020
Mintz RL, Lao YH, Chi CW, He S, Li M, Quek CH, Shao D, Chen B, Han J, Wang S, Leong KW.   +10 more
europepmc   +1 more source

GSK3B directs DNA repair choice and determines tumor response to PARP1 inhibition independent of BRCA1. [PDF]

J Clin Invest
Allam HS, Acklin-Wehnert S, Sadhukhan R, Patra M, Xia F.   +4 more
europepmc   +1 more source

Investigation of PARP1 as a Therapeutic Target for Glioblastoma [PDF]

This study investigated whether PARP1 could be a therapeutic target for GBM, measuring the effects of PARP1 inhibition by olaparib, alone and in combination with temozolomide and cisplatin on cell viability, proliferation, cell cycle arrest, apoptosis ...
Panchal, Krishna
core  

ExermiR-129-3p Enhances Muscle Function by Improving Mitochondrial Activity Through PARP1 Inhibition. [PDF]

J Cachexia Sarcopenia Muscle
Shin YJ, Yang JW, Jeong H, Kim J, Lee B, Kim JW, Lee SM, Kwak JY, Son YH, Kim KJ, Yang YR, Kim C, Kwon KS, Lee KP.   +13 more
europepmc   +1 more source