Results 221 to 230 of about 111,871 (303)

Treatment Response and Outcomes of Prostate Cancer Patients Carrying the Germline MMS22L F722fs Mutation

The Prostate, Volume 86, Issue 6, Page 727-731, May 2026.
ABSTRACT Background Methyl Methanesulfonate‐Sensitivity Protein 22‐Like (MMS22L) plays a key role in homology‐directed DNA repair, and experimental models have shown that its loss confers sensitivity to Poly (ADP‐ribose) polymerase inhibitors (PARPi).
Mayuko Kanayama, Violet A. Daniels, Marta Gielzak, Alex Brame, Misop Han, Li Jia, Jianfeng Xu, Tamara L. Lotan, Mario A. Eisenberger, Catherine H. Marshall, Patrick C. Walsh, William B. Isaacs, Jun Luo   +12 more
wiley   +1 more source

Metabolic subtyping reveals PDIK1L as a dual-functional regulator of progression and PARP inhibitor sensitivity in prostate cancer. [PDF]

Front Cell Dev Biol
Wang Z, Ge Q, Aihetaimujiang A, Zhang J, Lu J, Yang J, Chen Y, Qin B, Zhang H, Xu WH, Ye D.   +10 more
europepmc   +1 more source

Repurposing Hetrombopag for Multiple Myeloma by Targeting PNPO: A Celastrol‐Inspired Approach

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 5, May 2026.
Hetrombopag targeted PNPO to inhibit multiple myeloma. ABSTRACT Multiple myeloma (MM) is a malignancy of plasma cells whose excessive immunoglobulin production elevates reactive oxygen species (ROS), promoting pathogenesis. Active compounds from Traditional Chinese Medicine, such as celastrol, can exert antitumour effects by further increasing ROS ...
Tianyi Yu, Cheng Wang, Jingru Xie, Yongxin Wei, Hongwei Cui, Huaxia Zhang, Fan Zhou, Zhendong Deng, Ye Yang, Chunyan Gu   +9 more
wiley   +1 more source

Comprehensive genomic profiling for homologous recombination deficiency guides PARP inhibitor therapy recommendations in ovarian cancer. [PDF]

Pathol Oncol Res
Inci A, Witzel I, Moch H, Rahmani-Khajouei S, Zoche M, Samartzis EP.   +5 more
europepmc   +1 more source

Homoisoflavanone Delays Colorectal Cancer Progression via DNA Damage‐Induced Mitochondrial Apoptosis and Parthanatos‐Like Cell Death

Advanced Science, Volume 13, Issue 19, 2 April 2026.
Homoisoflavanone (HIF), a bioactive compound isolated from Polygonatum kingianum, selectively suppresses colorectal cancer progression by inducing DNA damage‐mediated mitochondrial apoptosis and parthanatos‐like cell death. HIF triggers mitochondrial dysfunction, including depolarized membrane potential, elevated ROS, and ATP depletion, while impairing
Hongjie Fan, Huzi Zhao, Pei Zhang, Pengfei Yu, Yunfei Ji, Gang Chen, Hongli Jin, Yanfang Liu, Jin Liu, Zhe‐Sheng Chen, Aiping Lyu, Xinmiao Liang, Yang Chen   +12 more
wiley   +1 more source

The PARP inhibitor olaparib promotes senescence in murine macrophages. [PDF]

Geroscience
Kieronska-Rudek A, Zuhra K, Ascenção K, Chlopicki S, Szabo C.   +4 more
europepmc   +1 more source

A Design of Experiments‐Based Chiral HPLC Method for the Quantification of Talazoparib and Enantiomeric Purity Determination in Pharmaceutical Formulations

Chirality, Volume 38, Issue 4, April 2026.
A design of experiments–based chiral HPLC method was developed for the enantiomeric separation and quantification of talazoparib in pharmaceutical formulations. Efficient resolution of the enantiomers (RS > 7) was achieved within 12 min. The method was validated and successfully applied to tablet analysis, and its environmental sustainability was ...
Sakine Atila Karaca, Sona Aliyeva, Duygu Yeniceli   +2 more
wiley   +1 more source

Differential PARP inhibitor responses in BRCA1-deficient and resistant cells in competitive co-culture. [PDF]

PLoS One
Soetomo SA, Sharp MF, Crismani W.
europepmc   +1 more source

Periodontitis and extracellular vesicles: Emerging roles in inflammation, tissue destruction and systemic crosstalk

Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.
Extracellular vesicles released from periodontal tissues and pathogens mediate local inflammation and disseminate systemically via the circulation. By transporting regulatory microRNAs and inflammatory cytokines, these vesicles link periodontitis to systemic inflammatory conditions and represent emerging targets for minimally invasive diagnostics and ...
Mai Ahmed, Dada Oluwaseyi Temilola, Mushi Matjila, Manogari Chetty   +3 more
wiley   +1 more source

Genetic evidence for PARP1 trapping as a driver of PARP inhibitor efficacy in BRCA mutant cancer cells. [PDF]

Nucleic Acids Res
Ribeiro J, Hansen K, van Beek L, Stubbs C, Frigola J, Talbot S, Bentouati S, Hall J, Wijnhoven PWG, Armenia J, Schimpl M, Forment JV, Albertella MR, O'Connor MJ, Illuzzi G.   +14 more
europepmc   +1 more source