Results 161 to 170 of about 240,365 (310)

A Generalized Minimal PBPK‐PD Model of Bispecific Antibodies: Case Studies and Applications in Drug Development

open access: yesCPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Bispecific antibodies (bsAbs), for which each arm binds a distinct molecular target, are developed to engage soluble and cell surface targets in different therapeutic indications. Three key examples of mechanisms of action (MoA) for bsAbs are (1) immune cell engagers that foster immune cell interactions with target cells, (2) bispecifics that ...
Phillip Spinosa   +4 more
wiley   +1 more source

Mapping Thermal Conductivity at the Atomic Scale: A Step toward the Thermal Design of Materials

open access: yesphysica status solidi (b), EarlyView.
The site‐projected thermal conductivity method resolves the local thermal conduction contribution per atom by decomposing the Green–Kubo thermal conductivity tensor under the harmonic approximation. It highlights thermally active sites and “thermal defects” within disordered or amorphous materials, enabling spatially resolved insights into atomic‐scale
Chinonso Ugwumadu   +3 more
wiley   +1 more source

CONCERT: A Modular Reconfigurable Robot for Construction

open access: yesJournal of Field Robotics, EarlyView.
ABSTRACT This paper presents CONCERT, a fully reconfigurable modular collaborative robot (cobot) for multiple on‐site operations in a construction site. CONCERT has been designed to support human activities in construction sites by leveraging two main characteristics: high‐power density motors and modularity. In this way, the robot is able to perform a
Luca Rossini   +18 more
wiley   +1 more source

Why Autonomous Vehicles Are Not Ready Yet: A Multi‐Disciplinary Review of Problems, Attempted Solutions, and Future Directions

open access: yesJournal of Field Robotics, EarlyView.
ABSTRACT Personal autonomous vehicles can sense their surrounding environment, plan their route, and drive with little or no involvement of human drivers. Despite the latest technological advancements and the hopeful announcements made by leading entrepreneurs, to date no personal vehicle is approved for road circulation in a “fully” or “semi ...
Xingshuai Dong   +13 more
wiley   +1 more source

Applying computer vision to accelerate monitoring and analysis of bird incubation behaviors: a case study using common eider nest camera footage

open access: yesRemote Sensing in Ecology and Conservation, EarlyView.
Visualization of the pipeline is divided into two primary segments: automated (i.e., the user adapts the code directly to build a custom computer vision model) and human‐in‐the‐loop (i.e., the user manually evaluates the output of the model). In step 1, raw imagery data are selected for training and testing datasets; ideally, these datasets are ...
Lindsay Veazey   +3 more
wiley   +1 more source

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