Results 61 to 70 of about 124,956,210 (348)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Dysarthric speech classification using glottal features computed from non-words, words and sentences

open access: yes, 2018
Dysarthria is a neuro-motor disorder resulting from the disruption of normal activity in speech production leading to slow, slurred and imprecise (low intelligible) speech.
Narendra N P   +3 more
core   +1 more source

Attention-based BILSTM network with part-of-speech features for Chinese text classification

open access: yesJournal of Hebei University of Science and Technology, 2018
The Chinese classification methods based on LSTM can correctly identify the category oftext, but such classification methods mainly focus on learning the text fragments related to the theme without aiming at other aspects of the words in context ...
Chengliang GAO, Hua XU, Kai GAO
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Uzbek language morphology analyser

open access: yesNatural Language Processing Journal
Although Uzbek is the official language of Uzbekistan, it remains one of the low-resource languages. In this paper, we propose a morphology analyser based on the Hunspell library.
Nikita Murzintcev   +1 more
doaj   +1 more source

QUANTIFYING STRUCTURES AND THE MORPHOLOGICAL CLASS OF THE NUMERAL [PDF]

open access: yesStudii si Cercetari Filologice: Seria Limbi Straine Aplicate, 2012
The numeral has always been a long debated subject in the Romanian grammar, due to its heterogeneous nature. The debate is closely connected to the grammarians’ generally stated idea that this lexical-grammatical class is denied the status of part of ...
Laura Ionică
doaj  

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Transposition – a Mechanism of Interaction between Semantics and Syntax

open access: yesPhilologia
The article examines the relationship between the meanings of words and their syntactic functions, extending the analysis to the interaction between lexicon and syntax.
Ion BĂRBUȚĂ
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Home - About - Disclaimer - Privacy