Results 211 to 220 of about 140,468 (296)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Late Preschool BMI Acceleration as the Strongest Predictor of Childhood Cardiometabolic Risk at School Entry: A Dual-Trajectory Cohort Study. [PDF]

Diabetes Metab Syndr Obes
Zhang S, Liu J, Li W, Wang J, Qiao Y, Zhang T, Dong W, Leng J, Feng L.   +8 more
europepmc   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Systematic effects of patient factors and scanner/protocol factors on a Restriction Spectrum Imaging (RSI) quantitative MRI biomarker for prostate cancer. [PDF]

Cancer Imaging
Do DD, Domingo MR, Conlin CC, Matthews I, Kallis K, Baxter MT, Ollison C, Song Y, Xu G, Zhong AY, Bagrodia A, Barrett T, Cooperberg M, Feng F, Hahn ME, Harisinghani M, Hollenberg GM, Javier-Desloges J, Kamran SC, Kane CJ, Kessler D, Kuperman J, Lee KL, Levine J, Liss MA, Margolis DJA, Murphy PM, Nakrour N, Ohliger MA, Osinski T, Pamatmat AJ, Pompa IR, Rakow-Penner R, Roberts JL, Santhosh K, Shabaik AS, Song D, Tempany CM, Trecarten S, Wehrli N, Weinberg EP, Woolen S, Dale AM, Seibert TM.   +43 more
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

<i>ACSL4</i>-driven ferroptosis susceptibility as a targetable vulnerability in monocytic acute myeloid leukemia. [PDF]

Front Oncol
De Marchi F, Gottardi M.
europepmc   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Blood Focused-Metabolomics and Transcriptomics Uncover Non-Linear Risk Association of Inadequate Dietary Choline Intake-Linked Metabolic Stress with MASLD Through Amino Acid Biomarkers, <i>BCAA</i> and <i>MTORC 1</i>/<i>AKT1</i>/<i>IRS1</i> Mechanistic Mediators: A Nested Case-Control Study. [PDF]

Int J Mol Sci
Wu CH, Lin ML, Wang CY, Chang CY, Lee FJ, Cheng ML, Lin YS, Chen TW, Hsiao YT, Wang BW, Kuo CS, Huang RS.   +11 more
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Pulse pressure mediation and hypertension modulation: the impact of TyG index on renal function deterioration in CKD patients under the CKM syndrome framework. [PDF]

Front Endocrinol (Lausanne)
Zhu X, Liu X, An J, He Q, Wang S, Zhang Z, Yang Y, Zhuo L, Li W.   +8 more
europepmc   +1 more source