Results 91 to 100 of about 896,632 (275)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Homotopy perturbation method with modified Riemann –Liouville derivative for solving fractional- time partial differential equations

مجلة علوم ذي قار, 2019
The aim of this paper is to present an efficient and reliable treatment of the Homotopy perturbation method (HPM) and the modified Riemann –Liouville derivative for partial differential equations with fractional time derivative.
Abeer Majeed
doaj  

Using derivative and ratio spectra derivative: spectrophotometries as new data preprocessing method in partial least squares technique for resolving overlapped spectra of montelukast sodium, desloratadine, and levocetirizine dihydrochloride

Reviews in Analytical Chemistry, 2012
Chemometric techniques are widely used for resolving overlapped spectra in different analysis type including simultaneous determination of active ingredients in pharmaceutical preparation.
Palabiyik Ismail Murat, Caglayan Mehmet Gokhan, Onur Feyyaz   +2 more
doaj   +1 more source

The aleph partial derivative

Revista Técnica de la Facultad de Ingeniería, 1994
Summary: In this paper we define the ``aleph'' partial derivative through an adequate generalization of the usual concept of finite increment. The main properties of this operator are also established. This derivative extends the classical partial derivative in the same way that the ``aleph'' derivative [\textit{I.
N. Hayek, J. González, S. Falcón
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

PDGM-PINN: Partial Derivative Guided Multi-Branch Physics-Informed Neural Network

Mathematics
With the development of scientific machine learning (SciML), the proposal of physics-informed neural networks (PINNs) has provided a powerful paradigm for solving partial differential equations (PDEs). While PINNs perform well in solving high-dimensional
Shangpeng Lei, Chenghan Yang, Roberts Grants, Uldis Grunde, Nadezhda Kunicina   +4 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source