Results 101 to 110 of about 896,632 (275)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Partial derivative games in thermodynamics: A cognitive task analysis

Physical Review Special Topics. Physics Education Research, 2014
Several studies in recent years have demonstrated that upper-division students struggle with the mathematics of thermodynamics. This paper presents a task analysis based on several expert attempts to solve a challenging mathematics problem in ...
Mary Bridget Kustusch, David Roundy, Tevian Dray, Corinne A. Manogue   +3 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Asymptotic Expansion of the Solutions to Time-Space Fractional Kuramoto-Sivashinsky Equations

Advances in Mathematical Physics, 2016
This paper is devoted to finding the asymptotic expansion of solutions to fractional partial differential equations with initial conditions. A new method, the residual power series method, is proposed for time-space fractional partial differential ...
Weishi Yin, Fei Xu, Weipeng Zhang, Yixian Gao   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Nonparametric estimation via partial derivatives

Journal of the Royal Statistical Society Series B: Statistical Methodology
Abstract Traditional nonparametric estimation methods often lead to a slow convergence rate in large dimensions and require unrealistically large dataset sizes for reliable conclusions. We develop an approach based on partial derivatives, either observed or estimated, to effectively estimate the function at near-parametric convergence ...
openaire   +3 more sources

Point derivation of partial geometries

European Journal of Combinatorics, 2003
The author generalizes a method for constructing partial quadrangles from generalized quadrangles. See \textit{F. De Clerck} and \textit{H. Van Maldeghem} [in Handbook of incidence geometry: buildings and foundations, 433--475 (1995; Zbl 0823.51010)] for the method and nomenclature.
openaire   +1 more source

Fractional advection differential equation within Caputo and Caputo–Fabrizio derivatives

Advances in Mechanical Engineering, 2016
In this research, we applied the variational homotopic perturbation method and q-homotopic analysis method to find a solution of the advection partial differential equation featuring time-fractional Caputo derivative and time-fractional Caputo–Fabrizio ...
Dumitru Baleanu, Bahram Agheli, Maysaa Mohamed Al Qurashi   +2 more
doaj   +1 more source