Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Modelling of spatial infection spread through heterogeneous population: from lattice to partial differential equation models. [PDF]
R Soc Open Sci, 2022 Vaziry A, Kolokolnikov T, Kevrekidis PG.
europepmc +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Regular Partial Differential Equations [PDF]
Proceedings of the American Mathematical Society, 1958 Birkhoff, Garrett, Mullikin, Thomas
openaire +2 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Conserved vectors with conformable derivative for certain systems of partial differential equations with physical applications [PDF]
, 2020 M. M. Qurashi
openalex +1 more source
Composing Partial Differential Equations with Physics-Aware Neural\n Networks [PDF]
, 2021 Matthias Karlbauer +5 more
openalex +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Existence of a Unique Solution to a Fractional Partial Differential Equation and Its Continuous Dependence on Parameters. [PDF]
Entropy (Basel), 2021 Stegliński R.
europepmc +1 more source
Some Open Problems in Partial Differential Equations Arising from Fluid Dynamics [PDF]
, 1997 Zhouping Xin
openalex +1 more source