Results 51 to 60 of about 692,049 (294)

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

open access: yesFEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura   +8 more
wiley   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

open access: yesFEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker   +9 more
wiley   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

open access: yesFEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin   +2 more
wiley   +1 more source

A Procedure to Construct Exact Solutions of Nonlinear Fractional Differential Equations

open access: yesThe Scientific World Journal, 2014
We use the fractional transformation to convert the nonlinear partial fractional differential equations with the nonlinear ordinary differential equations.
Özkan Güner, Adem C. Cevikel
doaj   +1 more source

λ-Symmetry and μ-Symmetry Reductions and Invariant Solutions of Four Nonlinear Differential Equations

open access: yesMathematics, 2020
On one hand, we construct λ-symmetries and their corresponding integrating factors and invariant solutions for two kinds of ordinary differential equations.
Yu-Shan Bai, Jian-Ting Pei, Wen-Xiu Ma
doaj   +1 more source

Photosynthesis under far‐red light—evolutionary adaptations and bioengineering of light‐harvesting complexes

open access: yesFEBS Letters, EarlyView.
Phototrophs evolved light‐harvesting systems adapted for efficient photon capture in habitats enriched in far‐red radiation. A subset of eukaryotic pigment‐binding proteins can absorb far‐red photons via low‐energy chlorophyll states known as red forms.
Antonello Amelii   +8 more
wiley   +1 more source

Rad27/FEN1 prevents accumulation of Okazaki fragments and ribosomal DNA copy number changes

open access: yesFEBS Letters, EarlyView.
The budding yeast Rad27 is a structure‐specific endonuclease. Here, the authors reveal that Rad27 is crucial for maintaining the stability of the ribosomal RNA gene (rDNA) region. Rad27 deficiency leads to the accumulation of Okazaki fragments and changes in rDNA copy number.
Tsugumi Yamaji   +3 more
wiley   +1 more source

Explicit Exact Solutions of the (2+1)-Dimensional Integro-Differential Jaulent–Miodek Evolution Equation Using the Reliable Methods

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 2020
In this article, we utilize the G′/G2-expansion method and the Jacobi elliptic equation method to analytically solve the (2 + 1)-dimensional integro-differential Jaulent–Miodek equation for exact solutions.
Supaporn Kaewta   +2 more
doaj   +1 more source

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