Results 41 to 50 of about 150,624 (241)

Denoising Analysis of Partial Discharge Acoustic Signal Based on SVMD-PCA

Journal of Applied Science and Engineering, 2023
Partial discharge (PD) acoustic signal detection is one of the effective means to assess the insulation status of power transformers. In actual monitoring, white noise is likely to cause strong interference to the partial discharge acoustic signal of the
Panpan Cao, Jianqiao Ma, Guangze Yang, Sheng Li   +3 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Partial discharge pulse propagation in power cable and partial discharge monitoring system [PDF]

IEEE Transactions on Dielectrics and Electrical Insulation, 2014
Partial discharge (PD) based condition monitoring has been widely applied to power cables. However, difficulties in interpretation of measurement results (location and criticality) remain to be tackled. This paper aims to develop further knowledge in PD signal propagation in power cables and attenuation by the PD monitoring system devices to address ...
Sheng, Bojie, Zhou, Chengke, Hepburn, D., Dong, Xiang, Peers, G., Zhou, Wenjun, Tang, Zeyang   +6 more
openaire   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Partial Discharge Inception and Breakdown Voltage Analysis in PCB-Based Electrode Structures

Applied Sciences
This paper investigates partial discharge (PD) characteristics and breakdown behavior in five electrode configurations fabricated from fiberglass circuit boards, including parallel electrode (PE), triangular electrode (TE), right-angled electrode (RE ...
Tzu-Ching Tai, Shiao-Yu Andrew Bao, Bharath Kumar Boyanapalli, Cheng-Chien Kuo, Chien-Kuo Chang   +4 more
doaj   +1 more source

Blind equalization of partial discharge channels [PDF]

Zbornik Radova: Elektrotehnički Institut "Nikola Tesla"
In the case of partial discharge signals, obtained during "online" monitoring or "off-line" tests of the generator, there is often interference between the direct and reflected signals or disturbances during propagation through the medium, i.e.
Žigić Aleksandar, Kartalović Nenad, Radoman Uroš, Kovačević Uroš   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source