Results 51 to 60 of about 46,049 (290)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Research of partial discharge detection for XLPE cable

Gong-kuang zidonghua, 2014
In order to extract characteristics of partial discharge signals, the paper proposed an adaptive threshold algorithm for processing partial discharge data by using ensemble empirical mode decomposition method for analysis of XLPE cable partial discharge ...
TANG Zhongyu, CHU Xin, HAN Gang, YU Yuese   +3 more
doaj   +1 more source

An improved optically based PD detection system for continuous on-line monitoring of HV cables [PDF]

, 2005
An optically-based remote sensing technique using a laser source, polarization scrambler, standard single mode fibers, fiber polarizer, electro-optic (EO) modulator and optical receiver, for continuous on-line monitoring of partial discharges (PD) in ...
Tian, Y., Sutton, S.J., Lewin, P.L., Swingler, S.G., Wilkinson, J.S., Schroeder, G.   +5 more
core   +1 more source

Partial discharge detection in modern power grid

, 2022
This paper presents a novel method for partial discharge detection. Generally, the presence of partial discharge in the power grid is unfavorable as it reduces the electricity transmission efficiency and also adversely affects the durability of the line.
Jakl, Jan, Šťastný, Ladislav, Mego, Roman, Liška, Jindřich, Künkel, Sven   +4 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

On the Electromagnetic Wave Behavior Due to Partial Discharge in Gas Insulated Switchgears: State-of-Art Review

IEEE Access, 2019
The rapid growth of gas insulated switchgears as a compact, efficient, and reliable device has recently been given great attention. Albeit gas insulated switchgears can seldom suffer from failure due to the high resiliency and robustness, some severe ...
Ahmad Darwish, Shady S. Refaat, Hamid A. Toliyat, Haitham Abu-Rub   +3 more
doaj   +1 more source

The Positive Role of the Partial Discharge Monitoring System in the Partial Discharge Detection of GIS Equipment

Journal of Physics: Conference Series, 2022
Abstract When gas insulated metal enclosed switchgear and controlgear (GIS) has internal discharge, some faults are difficult to find during inspections due to the enclosed metal casing. This paper introduces the event of the floating potential discharge inside the GIS equipment of a 500kV substation found by GIS on-line monitoring ...
Jiangtian Chen, Dongliang Wei, Zhi Wang, Congcong Liu, Weitao Shao, Weiling Shao   +5 more
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Localization for Dual Partial Discharge Sources in Transformer Oil Using Pressure-Balanced Fiber-Optic Ultrasonic Sensor Array

Sensors
The power transformer is one of the most crucial pieces of high-voltage equipment in the power system, and its stable operation is crucial to the reliability of power transmission.
Feng Liu, Yansheng Shi, Shuainan Zhang, Wei Wang   +3 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source