Results 41 to 50 of about 6,376,169 (271)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Global Attractor for Partial Functional Differential Equations with State-Dependent Delay

open access: yesAbstract and Applied Analysis, 2013
This work aims to investigate the existence of global attractors for a class of partial functional differential equations with state-dependent delay. Using the classic theory about global attractors in infinite dimensional dynamical systems, we obtain ...
Zhimin He, Bo Du
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Asymptotic behavior of solutions of a partial functional differential equation

open access: yesElectronic Journal of Differential Equations, 2000
The asymptotic behavior of solutions of an asymptotically autonomous partial functional differential equation is investigated. The aim of the present paper is to extend our earlier result for ordinary functional differential equations and difference ...
Gyula Farkas
doaj  

Bounder solution on a strip to a system of nonlinear hyperbolic equations with mixed derivatives

open access: yesҚарағанды университетінің хабаршысы. Математика сериясы, 2016
The system of nonlinear hyperbolic equations with mixed derivatives is considered on the strip. Time variable of the unknown function changes on the whole axis, and the spatial variable belongs to a finite interval.
D.S. Dzhumabaev, S.M. Temesheva
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Andrzej Lasota's selected results [PDF]

open access: yesOpuscula Mathematica, 2008
In this article we recall Andrzej Lasota's selected results which either indicated new directions of research, or layed the foundations for new approaches, or solved interesting problems. The area of mathematical interests of Professor Andrzej Lasota was
Józef Myjak
doaj  

Reduction of Linear Functional Systems using Fuhrmann's Equivalence

open access: yesSultan Qaboos University Journal for Science, 2016
Functional systems arise in the treatment of systems of partial differential equations, delay-differential equations, multidimensional equations, etc. The problem of reducing a linear functional system to a system containing fewer equations and unknowns ...
Mohamed S. Boudellioua
doaj   +1 more source

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