Results 111 to 120 of about 1,401,079 (253)

Hippo Pathway–YAP/TAZ Signaling: Molecular Mechanisms, Biological Function, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
The Hippo–YAP/TAZ–TEAD pathway integrates mechanical and biochemical cues to govern organ growth, regeneration, cancer, and fibrosis. This review dissects pathway physiology, TEAD structural pharmacology and ligandable pockets, and therapeutic strategies spanning palmitoylation‐pocket inhibitors, PROTAC degraders, and gene/RNA therapies, highlighting ...
Xiaodan Qu, Zhan‐you Wang
wiley   +1 more source

Nurse-led multidisciplinary care improves recovery and quality of life after hepatectomy for liver cancer: A radiological imaging-based evaluation

Journal of Radiation Research and Applied Sciences
Background: Primary liver cancer often requires partial hepatectomy, but postoperative liver regeneration and quality of life remain suboptimal. This study sought to assess the association of a nurse-led multidisciplinary collaborative (NMC) care model ...
Jiajie Xu, Jiafei Xu, Qing Zhou
doaj   +1 more source

Optimized Ex Vivo Human Liver Slice Culture Maintains Extended Viability and Function for Hepatotoxicity Testing

Advanced Science, Volume 13, Issue 52, 18 September 2026.
An optimized ex vivo human liver slice culture system preserves tissue architecture, hepatocyte function, and immune‐stromal complexity for at least five days. By refining slice thickness, oxygenation, air‐liquid interface, and extracellular matrix support, the platform enables human‐relevant hepatotoxicity testing and mechanistic studies, offering a ...
Huiche Feng, Cinzia Esposito, Andrej Benjak, Matthias S. Matter, Miriam Cieri, Camilla De Carlo, Philipp Sedlaczek, Fabian Haak, Mattia Marinucci, Gabriel Fridolin Hess, Otto Kollmar, Mairene Coto‐Llerena, Luca Di Tommaso, Visar Vela, Lukas Bubendorf, Luigi M. Terracciano, Charlotte K. Y. Ng, Salvatore Piscuoglio   +17 more
wiley   +1 more source

Recent Advances in Functional Liver Volumetry: Emphasis on 99mTc‐GSA SPECT/CT Fusion Imaging

Annals of Gastroenterological Surgery, Volume 10, Issue 5, Page 1428-1440, September 2026.
Functional liver volumetry enables more accurate assessment of the future liver remnant by integrating anatomical and functional information, improving risk stratification before major hepatectomy. Among available techniques, 99mTc‐GSA SPECT/CT fusion imaging enables precise regional functional assessment and more reliable prediction of post ...
Toru Beppu, Toshiro Masuda, Yasunori Nagayama, Hidetoshi Nitta, Hiromitsu Hayashi   +4 more
wiley   +1 more source

Study on influencing factors of recovery of gastrointestinal function after partial hepatectomy in liver cancer patients with liver cirrhosis

Huli yanjiu, 2018
Objective:To probe into the influencing factors of recovery of gastrointestinal function after partial hepatectomy in liver cancer patients complicated with liver cirrhosis.Methods:A total of 102 liver cancer patients complicated with liver cirrhosis ...
黄楚青, 陈似霞, 陈冬梅, 莫新少   +3 more
doaj  

P³² uptake in DNA nucleotides after partial hepatectomy and after unilateral nephrectomy

, 1961
Deoxyribonucleic acid (DNA) synthesis as reflected in the specific activity of DNA nucleotides 12 hr after intraperitoneal injection of P32 has been compared after partial hepatectomy and after unilateral nephrectomy.
David P. Simpson
core   +1 more source

Prognostic Impact of Arterial Phase Hyperenhancement After Proton Beam Therapy for Untreated Solitary Hepatocellular Carcinoma

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Purpose To evaluate the significance of persistent arterial‐phase hyperenhancement (APHE) on contrast‐enhanced CT/MRI at 6 and 12 months after proton beam therapy (PBT) for hepatocellular carcinoma (HCC). Methods We retrospectively analyzed 108 patients with solitary HCC without vascular invasion who underwent definitive PBT as initial ...
Hikaru Niitsu, Masashi Mizumoto, Yinuo Li, Masahiko Harada, Takuya Sawada, Masaaki Goto, Taisuke Sumiya, Keiichiro Baba, Takeshi Fujisawa, Masatoshi Nakamura, Toshiki Ishida, Takashi Iizumi, Takashi Saito, Haruko Numajiri, Kei Nakai, Yoshiko Oshiro, Hideyuki Sakurai   +16 more
wiley   +1 more source

Enhancement of adult liver regeneration in mice through the hepsin-mediated epidermal growth factor receptor signaling pathway

Communications Biology
Given the widespread use of partial hepatectomy for treating various liver pathologies, understanding the mechanisms of liver regeneration is vital for enhancing liver resection and transplantation therapies. Here, we demonstrate the critical role of the
Yu-Fei Tsai, Mo-Chu Fang, Chien-Hung Chen, I-Shing Yu, Chia-Tung Shun, Mi-Hua Tao, Cheng-Pu Sun, Jean Lu, Jin-Chuan Sheu, Yu-Chen Hsu, Shu-Wha Lin   +10 more
doaj   +1 more source

Mild steatosis does not impair liver regeneration after partial hepatectomy.

, 2015
(A) Graph represents the restoration of liver mass over the 7-days duration after partial hepatectomy. (B) Immunohistochemical staining of Ki-67 (yellow arrows show ki-67 positive cells) in mice on a CD-AA diet (right panel) or a CS-AA diet (left panel ...
Golnar Karimian (108501), Marc Kirschbaum (830329), Ton Lisman (46337), Zwanida J. Veldhuis (830330), Robert J. Porte (447490), Fernanda Bomfati (830331)   +5 more
core   +1 more source

Synchronous Vaginal and Liver Metastases in Rectosigmoid Cancer: Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Vaginal metastasis from colorectal cancer is extremely rare. We report the case of a 58‐year‐old postmenopausal woman with rectosigmoid adenocarcinoma and synchronous liver and vaginal metastases who initially presented with gastrointestinal symptoms followed by vaginal bleeding.
Tamader Alyaarabi, Mahmood Al‐Dhaheri, Hamza A. Abdul‐Hafez, Ammar Aleter, Noof Al Naimi, Mohamed Kurer, Mohamed Abunada, Ali Toffaha   +7 more
wiley   +1 more source