Results 51 to 60 of about 880,930 (320)
Robust partial least squares path modeling [PDF]
Behaviormetrika, 2019 AbstractOutliers can seriously distort the results of statistical analyses and thus threaten the validity of structural equation models. As a remedy, this article introduces a robust variant of Partial Least Squares Path Modeling (PLS) and consistent Partial Least Squares (PLSc) called robust PLS and robust PLSc, respectively, which are robust against ...
Tamara Schamberger +3 more
openaire +3 more sources
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Partial Least Squares: A Versatile Tool for the Analysis of High-Dimensional Genomic Data [PDF]
, 2005 Partial Least Squares (PLS) is a highly efficient statistical regression technique that is well suited for the analysis of high-dimensional genomic data.
Boulesteix, Anne-Laure +1 more
core +2 more sources
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Multi-omics data integration analysis of prostate cancer based on sparse least partial squares regression algorithm based on hypergraph regularization [PDF]
, 2023 Ruohui Huang +8 more
openalex +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Composite indices based on partial least squares [PDF]
, 2015 In this paper, we compare Principal Component Analysis (PCA) and Partial Least Squares (PLS) methods to generate weights for composite indices. In this context we also consider various treatments of non-metric variables when constructing such composite ...
Dreher, Axel +3 more
core
Mining for genotype-phenotype relations in Saccharomyces using partial least squares
BMC Bioinformatics, 2011 Background Multivariate approaches are important due to their versatility and applications in many fields as it provides decisive advantages over univariate analysis in many ways.
Sæbø Solve +4 more
doaj +1 more source
Chemical Engineering Transactions, 2020 With the goal of shaping a smart, economically-sustainable palm oil refining industry, this paper aims to improve the prediction modelling of Refined, Bleached and Deodorized Palm Oil (RBDPO) quality for early quality fault detection and remediation via ...
Wai Hoong Khu +6 more
doaj +1 more source