Results 71 to 80 of about 880,930 (320)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Bin-3-Way-PARAFAC-PLS: A 3-Way Partial Least Squares for Binary Response

open access: yesAxioms
In various research domains, researchers frequently encounter multiple datasets pertaining to the same subjects, with one dataset providing explanatory variables for the others.
Elisa Frutos-Bernal   +2 more
doaj   +1 more source

Partial least squares for dependent data [PDF]

open access: yesBiometrika, 2016
The partial least squares algorithm for dependent data realisations is considered. Consequences of ignoring the dependence for the algorithm performance are studied both theoretically and in simulations. It is shown that ignoring certain non-stationary dependence structures leads to inconsistent estimation.
Singer, M.   +3 more
openaire   +5 more sources

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

open access: yesFEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul   +3 more
wiley   +1 more source

Systems Analysis by Partial Least Squares [PDF]

open access: yes, 1983
This Collaborative Paper is one of a series embodying the outcome of a workshop and conference on Economic Structural Change: Analytical Issues, held at IIASA in July and August 1983.
Wold, H.
core  

Optimization Method of Fusing Model Tree into Partial Least Squares

open access: yesITM Web of Conferences, 2017
Partial Least Square (PLS) can’t adapt to the characteristics of the data of many fields due to its own features multiple independent variables, multi-dependent variables and non-linear.
Yu Fang   +5 more
doaj   +1 more source

Partial Least Squares Regression Performs Well in MRI-Based Individualized Estimations

open access: yesFrontiers in Neuroscience, 2019
Estimation of individuals’ cognitive, behavioral and demographic (CBD) variables based on MRI has attracted much research interest in the past decade, and effective machine learning techniques are of great importance for these estimations.
Chen Chen, Xuyu Cao, Lixia Tian
doaj   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

open access: yesFEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah   +8 more
wiley   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

open access: yesFEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli   +9 more
wiley   +1 more source

Partial Least Squares Regression on Symmetric Positive-Definite Matrices

open access: yesRevista Colombiana de Estadística, 2013
Recientemente ha habido un aumento en el interés de analizar diferentes tipos de datos variedad-valuados, dentro de los cuáles aparecen los datos de matrices simétricas definidas positivas.
RAÚL ALBERTO PÉREZ   +1 more
doaj  

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