Results 111 to 120 of about 3,648,084 (297)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Effective fault detection in structural health monitoring systems
Advances in Mechanical Engineering, 2019 A new fault detection technique is considered in this article. It is based on kernel partial least squares, exponentially weighted moving average, and generalized likelihood ratio test.
Marwa Chaabane +5 more
doaj +1 more source
Double Robust Estimation in Longitudinal Marginal Structural Models [PDF]
, 2003 Consider estimation of causal parameters in a marginal structural model for the discrete intensity of the treatment specific counting process (e.g.
van der Laan, Mark J., Yu, Zhuo
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
InformationThis study explores the characteristics of individual investors in crypto asset markets using machine learning and explainable artificial intelligence (XAI) methods.
Timotej Jagrič +3 more
doaj +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Local Likelihood Estimation of Truncated Regression and Its Partial Derivatives: Theory and Application [PDF]
In this paper we propose a very flexible estimator in the context of truncated regression that does not require parametric assumptions. To do this, we adapt the theory of local maximum likelihood estimation.
Byeong U. Park +2 more
core
Computational Methods in Survival Analysis [PDF]
, 2004 Survival analysis is widely used in the fields of medical science, pharmaceutics, reliability and financial engineering, and many others to analyze positive random phenomena defined by event occurrences of particular interest.
Kamakura, Toshinari
core
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source