Results 131 to 140 of about 309,663 (301)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Chapter 9: Partial Response Maximum Likelihood (PRML) [PDF]
, 2007 Introduction to PRML Detection System Recently, researchers from IBM laboratories reported the results of an experiment demonstrating that an areal density of 1 gigabit per square inch could be achieved for the storage and reliable retrieval of digital ...
Od Pr Ml
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Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Generalized empirical likelihood estimators and tests under partial, weak and strong identification [PDF]
The principal purpose of this paper is to describe the performance of generalized empirical likelihood (GEL) methods for time series instrumental variable models specified by nonlinear moment restrictions when identification may be weak.
Patrik Buggenberger, Richard Smith
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The importance of second-order interactions in a forest choice experiment. A partial log-likelihood analysis [PDF]
Environmental Economics, 2011 Marek Giergiczny +3 more
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MathematicsThis study introduces an objective Bayesian approach for estimating the reliability of a multicomponent stress–strength model based on the Pareto distribution under an adaptive progressive Type-II censoring scheme. The proposed method is developed within
Young Eun Jeon, Yongku Kim, Jung-In Seo
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Censored Partial Linear Models and Empirical Likelihood [PDF]
Consider the partial linear model Yi=X[tau]i[beta]+g(Ti)+[var epsilon]i, i=1, ..., n, where [beta] is a p-1 unknown parameter vector, g is an unknown function, Xi's are p-1 observable covariates, Ti's are other observable covariates in [0, 1], and Yi ...
Qin, Gengsheng, Jing, Bing-Yi
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