Results 111 to 120 of about 1,292,486 (242)

Testing Homogeneity of Time-Continuous Rating Transitions [PDF]

Banks could achieve substantial improvements of their portfolio credit risk assessment by estimating rating transition matrices within a time-continuous Markov model, thereby using continuous-time rating transitions provided by internal rating systems ...
Lawrenz, Claudia, Tschiersch, Patrick, Weißbach, Rafael   +2 more
core  

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

The importance of second-order interactions in a forest choice experiment. A partial log-likelihood analysis [PDF]

Environmental Economics, 2011
Marek Giergiczny, Pere Riera, Joan Mogas, Pierre-Alexandre Mahieu   +3 more
doaj  

nference in Graphical Gaussian Models with Edge and Vertex Symmetries with the gRc Package for R

Journal of Statistical Software, 2007
In this paper we present the R package gRc for statistical inference in graphical Gaussian models in which symmetry restrictions have been imposed on the concentration or partial correlation matrix.
Søren Højsgaard, Steffen L. Lauritzen
doaj  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Objective Framework for Bayesian Inference in Multicomponent Pareto Stress–Strength Model Under an Adaptive Progressive Type-II Censoring Scheme

Mathematics
This study introduces an objective Bayesian approach for estimating the reliability of a multicomponent stress–strength model based on the Pareto distribution under an adaptive progressive Type-II censoring scheme. The proposed method is developed within
Young Eun Jeon, Yongku Kim, Jung-In Seo
doaj   +1 more source

Asymptotic Behavior of Cox's Partial Likelihood and its Application to Variable Selection. [PDF]

Stat Sin, 2018
Li R, Ren JJ, Yang G, Yu Y.
europepmc   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Partial likelihood estimation of isotonic proportional hazards models. [PDF]

Biometrika, 2018
Chung Y, Ivanova A, Hudgens MG, Fine JP.
europepmc   +1 more source