Results 51 to 60 of about 309,663 (301)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Revisiting Strategies for Fitting Logistic Regression for Positive and Unlabeled Data
International Journal of Applied Mathematics and Computer Science, 2022 Positive unlabeled (PU) learning is an important problem motivated by the occurrence of this type of partial observability in many applications. The present paper reconsiders recent advances in parametric modeling of PU data based on empirical likelihood
Wawrzeńczyk Adam, Mielniczuk Jan
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Empirical likelihood for partial linear models with fixed designs [PDF]
, 1999 The empirical likelihood method of Owen [Owen, A., 1988. Empirical likelihood ratio confidence intervals for single functional. Biometrika 75, 237-249], is extended to partial linear models with fixed designs in this paper.
Jing, Bing Yi, Wang, Qi Hua
core +3 more sources
Comparative phylogenetic analysis of Dobrava-Belgrade virus L and S genetic segments isolated from an animal reservoir in Serbia [PDF]
Archives of Biological Sciences, 2014 The Dobrava-Belgrade virus (DOBV) is a member of the Bunyaviridae family, genus Hantavirus, possessing a single-stranded RNA genome consisting of three segments, designated L (large), M (medium) and S (small).
Nikolić Valentina +10 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Orthopaedic Journal of Sports MedicineObjectives: The optimal timing to perform an anterior cruciate ligament reconstruction (ACLR) has still become a debatable topic. Previous studies have suggested that an ACLR performed after six months resulted in inferior outcomes.
Calvin Calvin, Ghuna Arioharjo Utoyo
doaj +1 more source
Comparison of Survival Estimation Methods in the Analysis of Breast Cancer Data
Asian Pacific Journal of Cancer Care, 2022 Objective: In many epidemiological studies or clinical trials, Cox Proportional Hazard model is the most commonly used technique for the analysis of effects of covariates on survival time when time are continuous and ties are present.
Olubimpe M. Oladuti, Paul O. Olopha
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source