Results 71 to 80 of about 458,963 (267)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Milestones of Direct Variational Calculus and its Analysis from the 17th Century until today and beyond – Mathematics meets Mechanics – with restriction to linear elasticity

Computer Assisted Methods in Engineering and Science, 2019
This treatise collects and reflects the major developments of direct (discrete) variational calculus since the end of the 17th century until about 1990, with restriction to classical linear elastomechanics, such as 1D-beam theory, 2D-plane stress ...
Erwin Stein
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Some properties of matrix partial orderings

Linear Algebra and its Applications, 1989
The authors examine various properties of the star, minus, and Löwner partial orderings in the sets of \(m\times n\) and \(m\times m\) complex matrices [cf. \textit{M. P. Drazin}, Bull. Am. Math. Soc. 84, 139-141 (1978; Zbl 0395.20044), \textit{R. E. Hartwig}, Math. Jap. 25, 1-13 (1980; Zbl 0442.06006) and \textit{A. W. Marshall} and \textit{I. Olkin},
Baksalary, J. K., Pukelsheim, Friedrich, Styan, G. P. H.   +2 more
openaire   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Accretive partial transpose matrices and their connections to matrix means

Open Mathematics
Accretive partial transpose (APT) matrices have been recently defined, as a natural extension of positive partial transpose (PPT) matrices. In this paper, we discuss further properties of APT matrices in a way that extends some of those properties known ...
Aldabbas Eman, Sababheh Mohammad
doaj   +1 more source

Neural Matrix and Its Role in Preoperative Evaluation of Partial Epilepsy

Brain Science Advances, 2017
The network characteristic of the central neural system has been widely accepted as a basic fabric form. However, the matrix characteristics of neural network are still not fully understood.
Jingzhan Wu, Mingming Zhou
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

A Component Prediction Method for Flue Gas of Natural Gas Combustion Based on Nonlinear Partial Least Squares Method

The Scientific World Journal, 2014
Quantitative analysis for the flue gas of natural gas-fired generator is significant for energy conservation and emission reduction. The traditional partial least squares method may not deal with the nonlinear problems effectively.
Hui Cao, Xingyu Yan, Yaojiang Li, Yanxia Wang, Yan Zhou, Sanchun Yang   +5 more
doaj   +1 more source