Results 71 to 80 of about 1,846,051 (329)

SETDB2 Mitigates Podocyte Dysfunction in Diabetic Kidney Disease Through Epigenetic Silencing of SMAD3

Advanced Science, EarlyView.
SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li, Shimin Jiang, Qi Jin, Peng Qu, Yingjie Guo, Xushan Lan, Xinyu Li, Cuiting Sun, Sinan Ai, Xin Li, Weiliang Sun, Jing Guo, Wenge Li, Liang Peng, Lihong Liu   +14 more
wiley   +1 more source

Combined surgical and interventional management of a 3-year-old patient with bilateral nephroblastoma

Journal of Pediatric Surgery Case Reports, 2020
We present the case of a 3-year-old female patient diagnosed with stage V bilateral nephroblastoma with predominant blastemal component. The treatment protocol included preoperative chemotherapy, left partial nephrectomy, and postoperative chemotherapy ...
Bogdan Petrut, Adrian Surd, Rodica Voichita Cosnarovici, Vasile Vlad Hardo, Razvan George Rahota, Cristina Eliza Bujoreanu, Zeno Adrian Sparchez   +6 more
doaj   +1 more source

Reducing Operating Room Costs through Real Time Cost Information Feedback: A Pilot Study [PDF]

, 2015
Purpose: To create a protocol for providing real-time operating room (OR) cost feedback to surgeons. We hypothesize that this protocol will reduce costs in a responsible way without sacrificing quality of care.
Bahler, Clinton D., Ball, Kevin M., Hardacker, Thomas J., Sundaram, Chandru P., Tabib, Christian H.   +4 more
core   +1 more source

Polystyrene Microplastics Exposure Aggravates Clear Cell Renal Cell Carcinoma Progression via the NF‐κB and TGF‐β Signaling Pathways

Advanced Science, EarlyView.
This research provides the first comprehensive evidence that PS‐MPs exacerbate ccRCC progression by activating the NF‐κB and TGF‐β pathways. These findings establish PS‐MPs as an environmental risk factor for ccRCC progression and identify the NF‐κB and TGF‐β signaling as potential therapeutic targets to mitigate the adverse effects of ‐PS‐MPs exposure.
Shiqi Ye, Jianfeng Xiang, Siqi Zhou, Qintao Ge, Aihetaimujiang Anwaier, Kun Chang, Gang Wei, Jiahe Lu, Xi Tian, Shuxuan Zhu, Yuchen Jiang, Wei Zhang, Tingting Cai, Moran Xu, Dingwei Ye, Danfeng Xu, Tao Wang, Hailiang Zhang, Wenhao Xu   +18 more
wiley   +1 more source

Renal functional outcomes after surgery for renal cortical tumors

Journal of Kidney Cancer and VHL, 2015
Historically, radical nephrectomy represented the gold standard for the treatment of small (≤ 4cm) as well as larger renal masses.  Recently, for small renal masses, the risk of ensuing chronic kidney disease and end stage renal disease has largely ...
Danny Lascano, Julia B Finkelstein, G. Joel DeCastro, James M McKiernan   +3 more
doaj   +1 more source

Pathological T3a Upstaging of Clinical T1 Renal Cell Carcinoma: Outcomes According to Surgical Technique and Predictors of Upstaging. [PDF]

PLoS ONE, 2016
To evaluate the prognosis of pT3a upstaging from cT1 renal cell carcinoma, and to compare the outcomes of partial or radical nephrectomy in cases of pT3a upstaging.We reviewed the records of patients who underwent partial or radical nephrectomy for cT1 ...
Seung-Hwan Jeong, Jung Kwon Kim, Juhyun Park, Ho Joon Jeon, Min Young Yoon, Chang Wook Jeong, Ja Hyeon Ku, Hyeon Hoe Kim, Cheol Kwak   +8 more
doaj   +1 more source

Aneurysmectomy with partial nephrectomy on a living donor renal allograft: a case report. [PDF]

, 2013
Vascular anomalies among living kidney donors are seldom encountered and their presence offers a complex opportunity for every transplant surgeon. Furthermore, there has been an increasing trend with the use of marginal or kidneys with pathology to ...
Burke, George W, Chen, Linda, Ciancio, Gaetano, Paloyo, Siegfredo, Sageshima, Junichiro   +4 more
core   +2 more sources

The Simplified PADUA REnal (SPARE) nephrometry system: a novel classification of parenchymal renal tumours suitable for partial nephrectomy

BJU International, 2019
To simplify the original Preoperative Aspects and Dimensions Used for an Anatomical (PADUA) classification of renal tumours, generating a new system able to predict equally or better the risk of overall complications in patients undergoing partial ...
V. Ficarra, F. Porpiglia, A. Crestani, A. Minervini, A. Antonelli, N. Longo, G. Novara, G. Giannarini, C. Fiori, C. Simeone, M. Carini, V. Mirone   +11 more
semanticscholar   +1 more source

BHLHE40 Orchestrates Effector Tissue‐Resident Memory CD8+ T Cells and Limits Long‐Term Survival of Kidney Graft

Advanced Science, EarlyView.
An effector subset of TRM, defined as CD49a+PD1hi CD8+ TRM, represents a BHLHE40‐orchestrated resident immune component that, rather than circulating cells, plays as a major contributor to allograft rejection. ABSTRACT Tissue‐resident memory T cells (TRM), which function against tumors, infections, and non‐self antigens in organ transplantation ...
Junbo Li, Bo Yang, Tianhui Pan, Xi Zhou, Zhibo Ma, Du Tang, Bowen Xie, Jing Liu, Zhishui Chen, Peixiang Lan   +9 more
wiley   +1 more source

Robotic-assisted laparoscopic partial nephrectomy: initial experience in Brazil and a review of the literature

International Brazilian Journal of Urology, 2012
CONTEXT AND PURPOSE: Partial nephrectomy has become the standard of care for renal tumors less than 4 cm in diameter. Controversy still exists, however, regarding the best surgical approach, especially when minimally invasive techniques are taken into ...
Carlo Camargo Passerotti, Rodrigo Pessoa, Jose Arnaldo Shiomi da Cruz, Marcelo Takeo Okano, Alberto Azoubel Antunes, Adriano João Nesrallah, Marcos Francisco Dall'Oglio, Enrico Andrade, Miguel Srougi   +8 more
doaj   +1 more source